Lorenzo A. Cingolani

Whole-cell patch-clamp recordings in organotypic slices

Mathieu Letellier, Lorenzo A. Cingolani

fr, it (code pays fourni par la source)

Integrin-mediated adhesion drives microglial entry into the developing CNS

Fanny Jaudon, Lorenzo A. Cingolani

it (code pays fourni par la source)

RNA-targeted complement modulation: A new strategy to preserve synapses in the aging brain

Fanny Jaudon, Lorenzo A. Cingolani

it (code pays fourni par la source)

CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models

Ilaria Musante, Davide Cangelosi, Lorenzo Muzzi, Fanny Jaudon et autres

Abstract CACNA1A encodes the pore-forming α1A subunit of the CaV2.1 calcium channel, whose altered function is associated with various neurological disorders, including forms of ataxia, epilepsy, and migraine. In this study, we generated isogenic iPSC-derived neural cultures carrying CACNA1A loss-of-function mutations differently …

it (code pays fourni par la source)

Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism

Carmela Vitale, Fanny Jaudon, Rafael Luján, Martina Bartolucci et autres

Autism spectrum disorder is a complex neurodevelopmental disease characterized by altered cortical network excitability. Recent genetic studies have identified deep layer V cortical pyramidal neurons in the frontal cortex as central to autism pathophysiology, yet the cortical circuits, plasticity mechanisms and molecular …

it, es (code pays fourni par la source)

Unlocking mechanosensitivity: integrins in neural adaptation

Fanny Jaudon, Lorenzo A. Cingolani

it (code pays fourni par la source)

Nanoscale organization of CaV2.1 splice isoforms at presynaptic terminals: implications for synaptic vesicle release and synaptic facilitation

Lorenzo A. Cingolani, Agnes Thalhammer, Fanny Jaudon, Jessica Muià et autres

Abstract The distance between CaV2.1 voltage-gated Ca2+ channels and the Ca2+ sensor responsible for vesicle release at presynaptic terminals is critical for determining synaptic strength. Yet, the molecular mechanisms responsible for a loose coupling configuration of CaV2.1 in certain synapses or developmental …

it (code pays fourni par la source)

Regulation of dendritic spine length in corticopontine layer V pyramidal neurons by autism risk gene β3 integrin

Lucia Celora, Fanny Jaudon, Carmela Vitale, Lorenzo A. Cingolani

The relationship between autism spectrum disorder (ASD) and dendritic spine abnormalities is well known, but it is unclear whether the deficits relate to specific neuron types and brain regions most relevant to ASD. Recent genetic studies have identified a convergence of ASD …

it (code pays fourni par la source)

The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex

Edoardo Moretto, Federico Miozzo, Anna Longatti, Caroline Bonnet et autres

Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity. We found that, in rat hippocampal neurons, an intracellular pool …

it, fr (code pays fourni par la source)

Author response: The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex

Edoardo Moretto, Federico Miozzo, Anna Longatti, Caroline Bonnet et autres

it, fr (code pays fourni par la source)

CRISPR-mediated activation of autism gene Itgb3 restores cortical network excitability via mGluR5 signaling

Fanny Jaudon, Agnes Thalhammer, Lorena Zentilin, Lorenzo A. Cingolani

Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3 , the gene encoding the extracellular matrix receptor β3 integrin, was associated with ASD. Accordingly, Itgb3 knockout …

it (code pays fourni par la source)

CRISPR-Mediated Activation of αV Integrin Subtypes Promotes Neuronal Differentiation of Neuroblastoma Neuro2a Cells

Sara Riccardi, Lorenzo A. Cingolani, Fanny Jaudon

Neuronal differentiation is a complex process whose dysfunction can lead to brain disorders. The development of new tools to target specific steps in the neuronal differentiation process is of paramount importance for a better understanding of the molecular mechanisms involved, and ultimately …

it (code pays fourni par la source)