Carla J. Guthridge

PT2:03 Association of urinary biomarkers with histological features in diagnostic and per-protocol repeat kidney biopsies in lupus nephritis

Andrea Fava, C. Lee, Carla J. Guthridge, Dionysis Nikolopoulos et autres

Objectives Persistent intrarenal inflammation despite immunosuppression drives kidney damage in lupus nephritis (LN). Current guidelines rely on proteinuria to assess response, though it fails to reflect histological activity in over half of cases. Urinary biomarkers offer a promising noninvasive alternative to monitor …

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Persistent CD4 + T cell functional deficits during recovery from prolonged symptomatic SARS-CoV-2 infection

Jadith Ziegler, Christina Lawrence, Seán Turner, Nathan P. Pezant et autres

Abstract Symptoms of acute SARS-CoV-2 infection often resolve quickly but are sometimes associated with persistent immune dysfunction. The factors that predispose individuals to compromised immune function have not been well defined. We investigated CD4 + T cell phenotype and function in a …

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Broadened autoantibody profiling in incomplete lupus erythematosus 2448

Rebecca A Wood, Catriona A. Wagner, Judith A. James, Robert Hal Scofield et autres

Abstract Description Incomplete lupus erythematosus (ILE) is characterized by clinical and/or serological features suggestive of systemic lupus erythematosus (SLE) but insufficient for disease classification. While some ILE patients progress to SLE, many maintain a mild disease course. The mechanisms underlying ILE remain …

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Integrative omics identify increase of pattern recognition and ubiquitin related signatures specific to ANA+ at risk of SLE individuals 2370

Aleksandra Bylinska, Miles P. Smith, Rufei Lu, Ben Jones et autres

Abstract Description Anti-nuclear autoantibodies (ANA) appear years before SLE classification, however, most healthy ANA+ individuals will never develop clinical illness. We sought to identify molecular profiles driving transitions during preclinical autoimmunity development. Proteomic and transcriptomic profiles for 67 subjects (ANA-, ANA+, ILE; …

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Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment

Andrea Fava, Catriona A. Wagner, Carla J. Guthridge, Susan Macwana et autres

OBJECTIVE: Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response. METHODS: Patients with systemic lupus erythematosus …

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Shared and Distinct Urinary Proteomic Signatures of Lupus Nephritis and Other Glomerular Diseases

Andrea Fava, Alessandra Ida Celia, Daksh Saksena, Chen‐Yu Lee et autres

Background: Urinary biomarkers may detect histologically active lupus nephritis (LN). We tested candidate LN urinary proteins in other glomerular diseases to identify shared and specific biomarkers. Methods: Urine samples from patients with LN (n=234), ANCA-associated glomerulonephritis (n=17), IgA nephropathy (IgAN, n=30), membranous …

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POS0173 CLINICAL, HISTOLOGICAL, AND SEROLOGICAL PREDICTORS OF RENAL FUNCTION LOSS IN LUPUS NEPHRITIS

Shangzhu Zhang, LS Magder, DANIEL W. GOLDMAN, J. A. James et autres

Background: Up to a third of lupus nephritis (LN) patients will progress to end stage kidney disease (ESKD) which carries increased morbidity and mortality. Identifying early predictors of chronic kidney disease (CKD) progression could help stratify high-risk patients and refine treatment response …

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INVESTIGATING PREDICTIVE SERUM SOLUBLE MEDIATORS SPECIFIC TO ANA+ INDIVIDUALS AT RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH HIGH-THROUGHPUT PROTEOMICS

Aleksandra Bylinska, M. D. Smith, Rufei Lu, Ben Jones et autres

O060 / #518 Topic: AS08 - Cytokines and Cell Trafficking ABSTRACT CONCURRENT SESSION 10: INTEGRATING PROTEOMIC & TRANSCRIPTOMICS IN SLE 24-05-2025 10:40 AM - 11:40 AM Background/Purpose Anti-nuclear autoantibodies (ANAs) are detected years before SLE classification. However, most healthy ANA+ individuals will …

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Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response

Andrea Fava, Catriona A. Wagner, Carla J. Guthridge, Joseph M. Kheir et autres

OBJECTIVE: Autoantibodies are a hallmark of lupus nephritis (LN), but their association with LN classes and treatment response are not adequately known. In this study, we quantified circulating autoantibodies in the Accelerating Medicines Partnership LN longitudinal cohort to identify serological biomarkers of …

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POS1066 SINGLE-CELL MULTI-OMIC EVALUATION OF DIFFERENCES IN T CELL POPULATIONS IN PROGRESSION OF SLE

Aleksandra Bylinska, Martyn T. Smith, Rufei Lu, B Jones et autres

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POS0388 INTEGRATED SOLUBLE PROTEOMICS AND AUTOREACTOMICS: PREDICTING RENAL INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS

Joel M. Guthridge, Rufei Lu, B.R. Jones, Carla J. Guthridge et autres

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Ancestry-based differences in the immune phenotype are associated with lupus activity

Samantha R Slight-Webb, Kevin L. Thomas, Miles C. Smith, Catriona A. Wagner et autres

Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomics …

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