Kalai Mangai Muthukumarasamy

Usefulness of healthy aging models to study novel prevention strategies in the treatment of cardiac inflammation and atrial fibrillation: A narrative review

Andrew Rose, Kalai Mangai Muthukumarasamy, Harika Dasari, Pierrette Gaudreau et autres

Healthy aging is defined as remarkable longevity (beyond 90 years of age) accompanied by preserved functional status and absence of major clinical conditions. Although the incidence of cardiac arrhythmias, including atrial fibrillation (AF), increases with age, epidemiological studies revealed a paradoxical reduction …

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Modeling Atrial Fibrillation through Intermittent Tachypacing-Induced Remodeling in hiPSC-Derived Atrial Cardiomyocytes and Atrial Fibroblast

Paul Kozlowski, Kalai Mangai Muthukumarasamy, Amrish Deshmukh, André Monteiro da Rocha et autres

ABSTRACT Background Human in vitro models for atrial fibrillation (AF) are limited. Human-induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCMs) provide a valuable tool to study AF pathophysiology by facilitating in vitro modeling. Objectives To investigate the effects of an intermittent tachypacing protocol …

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Relevance of Targeting Oxidative Stress, Inflammatory, and Pro-Resolution Mechanisms in the Prevention and Management of Postoperative Atrial Fibrillation

Abir Attia, Kalai Mangai Muthukumarasamy, Doa’a Al-u’datt, Roddy Hiram

Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF can lead to severe complications, including stroke, myocardial infarction, and sudden death. AF risk factors include pathological aging and conditions such as obesity, diabetes, and hypertension. Clinical data revealed that cardiothoracic and …

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Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance

Xiaoyan Qi, Feng Xiong, Jiening Xiao, Kalai Mangai Muthukumarasamy et autres

ABSTRACT BACKGROUND Changes in mitochondria have been implicated in atrial fibrillation (AF), but their manifestations and significance are poorly understood. Here, we studied changes in mitochondrial morphology and function during AF and assessed the effect of a mitochondrial-targeted intervention in a large …

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Daily exposure to chlordecone, an organochlorine pesticide, increases cardiac fibrosis and atrial fibrillation vulnerability

Alexia Fundere, Andrew Rose, Feng Xiong, Kalai Mangai Muthukumarasamy et autres

CONTEXT: -ATPase. Conditions affecting these transmembrane pumps are often associated with cardiac arrhythmias (CA). However, little is known about the role of CLD on atrial fibrillation (AF) incidence, the most common type of CA. HYPOTHESES: 1) Daily ingestion of CLD induces arrhythmogenic …

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Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

Bo Hjorth Bentzen, Sofia Hammami Bomholtz, Rafel Simó‐Vicens, Lasse Folkersen et autres

Aims: Small conductance Ca2+-activated K+-channels (SK-channels, KCa2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of KCa2-channels that is currently in clinical development for treatment of AF. The aim of this study is to …

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Impact of arrhythmogenic calmodulin variants on small conductance Ca 2+ ‐activated K + (SK3) channels

Arnela Saljic, Kalai Mangai Muthukumarasamy, Jonas M. la Cour, Kim Boddum et autres

Calmodulin (CaM) is a ubiquitous Ca2+-sensing protein regulating many important cellular processes. Several CaM-associated variants have been identified in a small group of patients with cardiac arrhythmias. The mechanism remains largely unknown, even though a number of ion channels, including the ryanodine …

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The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

Jeppe Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó‐Vicens et autres

Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhytmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IKCa, is considered a promising new target for …

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Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using in vitro and in vivo model systems

Somanath Kundu, Sandhya Bansal, Kalai Mangai Muthukumarasamy, Chetana Sachidanandan et autres

vessel formation studies performed with human umbilical vein endothelial cells (HUVECs), whereas the hydrophobic LCA reduced tubulogenesis and was toxic to the zebrafish embryos. We validated that CDCA enhances angiogenesis by increasing the expression of vascular growth factor receptors (VEGFR1 and VEGFR2) …

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Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays

Kalai Mangai Muthukumarasamy, Kishor L. Handore, Dipti N. Kakade, Madhuri Vikas Shinde et autres

Noreremophilanes are a rare class of cis-hydrindanes produced by genus Ligularia herbaceous plants which are known to exhibit interesting biological activities. We synthesized cis-hydrindanes based on a naturally occurring noreremophilane scaffold using a Diels-Alder/aldol sequence and screened them for multiple biological activities …

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CCDC 1009597: Experimental Crystal Structure Determination

Kalai Mangai Muthukumarasamy, Kishor L. Handore, Dipti N. Kakade, Madhuri Vikas Shinde et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …