Oliver Nitsche

A longitudinal multi-omic dataset of pediatric cystic fibrosis patients receiving lumacaftor/ivacaftor therapy: clinical, microbiome, inflammatory and metabolomic measurements collected over 24 months

Rebecca L. Knoll, Virginia Rossow, Juliane Rössler, Katja Hilbert et autres

This article describes a longitudinal multiomic dataset generated within a prospective phase IV pilot study of eight children with cystic fibrosis homozygous for the F508del mutation who initiated lumacaftor/ivacaftor therapy. Participants were followed for up to 24 months with repeated collection of …

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An Observational Study of the Inn Valley Exit Jet in Southern Germany

Katrin Sedlmeier, Meinolf Kossmann, Ivan Paunovic, Oliver Nitsche et autres

ABSTRACT The Inn Valley exit jet (VEJ) is a frequently occurring nocturnal wind phenomenon in the exit region of the Inn Valley, north of a valley constriction before the valley broadens into the foreland. Using upper‐air and surface measurements conducted during the …

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Persistierendes seitendifferentes Atemgeräusch im Kleinkindalter bei postinfektiöser Bronchiolitis obliterans (Swyer-James-Syndrom)

A W de Puiseau, Daniel Schreiner, Gundula Staatz, Oliver Nitsche

Einführung: Persistierende seitendifferente Auskultationsbefunde im Kleinkindalter stellen eine diagnostische Herausforderung dar. Bei ansonsten klinisch unauffälligem Befund sollte bei vorangegangen (Broncho-)Pneumonien, aber auch rezidivierenden Bronchitiden, an die postinfektiöse Bronchiolitis obliterans (PIBO) gedacht werden. Wir berichten über einen zweijährigen Patienten mit PIBO und radiologischem …

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Incidence and Remission of Atopic Dermatitis in a German Birth Cohort

Chu-Wei Hung, Stephanie Roll, Katja Icke, Linus Grabenhenrich et autres

Importance: Patterns of incidence and factors associated with remission of atopic dermatitis (AD) from birth to adulthood remain understudied. Objectives: To examine incidence of AD, its remission probability and trajectories, and early-life factors associated with it in a prospective study from birth …

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CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial

Rebecca L. Knoll, Melanie Brauny, Evelyn Robert, Louisa Cloos et autres

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to impaired CFTR function, mucus accumulation, chronic infections, and inflammation. The triple combination elexacaftor/tezacaftor/ivacaftor (ETI) has transformed CF treatment by restoring CFTR function. However, how ETI-induced physiological …

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Health status and therapy decisions in children with cystic fibrosis in Germany and Austria who switched treatment from LUM/IVA to ELX/TEZ/IVA: Interim analysis from the noninterventional DECIDE study 809–127

Olaf Eickmeier, Ute Graepler-Mainka, Florian Stehling, Olaf Sommerburg et autres

Introduction: DECIDE is an ongoing, 5-year, noninterventional, single-arm, chart review study following the CF treatment journey of children aged 2–11 years (y) in Germany and Austria with CF who are homozygous for F508del-CFTR and received lumacaftor/ivacaftor (LUM/IVA) therapy. Here, we describe the …

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The Inn Valley exit jet: results of the TEAMx pre-campaign

Katrin Sedlmeier, Meinolf Kossmann, Ivan Paunović, Astrid Eichhorn-Müller et autres

Previous studies have found a pronounced nocturnal low-level jet at the exit of the Inn Valley north of the valley contraction near Schwaigen which reaches into the Alpine foreland (e.g. Pamperin and Stilke, 1985 as part of the MERKUR experiment or a …

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Komplexer Fall von Systemischer Sklerodermie im Kindesalter mit kardiopulmonaler Komplikation

Oliver Nitsche, Daniel Schreiner, Christoph Kampmann, Krystyna Poplawska

Hintergrund Die Systemische Sklerodermie (SSc) im Kindesalter ist bei einer Inzidenz von ungefähr 3 Patienten pro 10 Mio. Kinder eine sehr seltene Erkrankung. Die kardiopulmonale Beteiligung findet sich bei 45% der Patienten. Diese interstitielle Lungenerkrankung kann mit zunehmender Fibrose zur pulmonalen Hypertension …

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CFTR Modulator Therapy Reshapes the Microbiome Across Ecological Niches Toward Health in Cystic Fibrosis

Rebecca L. Knoll, Melanie Brauny, Evelyn Robert, Louisa Cloos et autres

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TEAMx-PC22 (TEAMx pre-campaign 2022) – DWD Doppler wind lidar data set (SLXR172)

Ronny Leinweber, Ivan Paunović, Oliver Nitsche, Meinolf Kossmann et autres

This dataset contains data measured by DWD with a Doppler Wind Lidar SLXR172 during the TEAMx pre-campaign 2022. More details about TEAMx can be found at http://www.teamx-programme.org. DATA SET DESCRIPTION 1. Measurement location and time period Measurements with the SLXR172 were collected …

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TEAMx-PC22 (TEAMx pre-campaign 2022) – DWD Doppler wind lidar data set (SLXR172)

Ronny Leinweber, Ivan Paunović, Oliver Nitsche, Meinolf Kossmann et autres

This dataset contains data measured by DWD with a Doppler Wind Lidar SLXR172 during the TEAMx pre-campaign 2022. More details about TEAMx can be found at http://www.teamx-programme.org. DATA SET DESCRIPTION 1. Measurement location and time period Measurements with the SLXR172 were collected …

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TEAMx-PC22 (TEAMx pre-campaign 2022) – DWD AWS dataset for the Inn Valley exit area

Ivan Paunović, Oliver Nitsche, Meinolf Kossmann, Katrin Sedlmeier

This dataset contains data measured at 5 automatic weather stations operated by the German Meteorological Service (DWD) during the TEAMx pre-campaign 2022. More details about TEAMx can be found at http://www.teamx-programme.org. DATA SET DESCRIPTION 1. Measurement location, instrumentation and measured variables The …

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