Melanie Brauny

CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial

Rebecca L. Knoll, Melanie Brauny, Evelyn Robert, Louisa Cloos et autres

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to impaired CFTR function, mucus accumulation, chronic infections, and inflammation. The triple combination elexacaftor/tezacaftor/ivacaftor (ETI) has transformed CF treatment by restoring CFTR function. However, how ETI-induced physiological …

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DNA Damage and Inflammatory Response of p53 Null H358 Non-Small Cell Lung Cancer Cells to X-Ray Exposure Under Chronic Hypoxia

Hasan Nisar, Melanie Brauny, Frederik M. Labonté, Claudia Schmitz et autres

Hypoxia-induced radioresistance limits therapeutic success in cancer. In addition, p53 mutations are widespread in tumors including non-small cell lung carcinomas (NSCLCs), and they might modify the radiation response of hypoxic tumor cells. We therefore analyzed the DNA damage and inflammatory response in …

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CFTR Modulator Therapy Reshapes the Microbiome Across Ecological Niches Toward Health in Cystic Fibrosis

Rebecca L. Knoll, Melanie Brauny, Evelyn Robert, Louisa Cloos et autres

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Gut bacteria thwart the blood sugar-lowering effect of acarbose

Melanie Brauny, Lisa Maier

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Hypoxia Changes Energy Metabolism and Growth Rate in Non-Small Cell Lung Cancer Cells

Hasan Nisar, Paulina Mercedes Sanchidrián González, Melanie Brauny, Frederik M. Labonté et autres

Hypoxia occurs in 80% of non-small cell lung carcinoma (NSCLC) cases, leading to treatment resistance. Hypoxia’s effects on NSCLC energetics are not well-characterized. We evaluated changes in glucose uptake and lactate production in two NSCLC cell lines under hypoxia in conjunction with …

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The Cyanobacterial “Nutraceutical” Phycocyanobilin Inhibits Cysteine Protease Legumain

Isabel V. L. Wilkinson, Gabriel Castro‐Falcón, Maria Cinta Roda‐Serrat, Trevor N. Purdy et autres

The blue biliprotein phycocyanin, produced by photo-autotrophic cyanobacteria including spirulina (Arthrospira) and marketed as a natural food supplement or "nutraceutical," is reported to have anti-inflammatory, antioxidant, immunomodulatory, and anticancer activity. These diverse biological activities have been specifically attributed to the phycocyanin chromophore, …

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Metabolism and X-ray irradiation-induced responses of the human non-small cell lung cancer cell line H358 in hypoxia

Melanie Brauny

With a survival rate of around 15 %, lung cancer is the deadliest cancer of our today´s world. One of its main treatment pillars - radiation therapy - is severely limited by hypoxia, a state of low environmental oxygen concentration which is …

Molecular surveillance and temporal monitoring of malaria parasites in focal Vietnamese provinces

Bui Van Long, Genevieve Allen, Melanie Brauny, Le Thi Kieu Linh et autres

BACKGROUND: While the World Health Organization (WHO) Southeast Asia region has the second highest incidence of malaria worldwide, malaria in Vietnam is focal to few provinces, where delayed parasite clearance to anti-malarial drugs is documented. This study aims to understand Plasmodium species …

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