Taha Azad

A Proposal for an Ultrasensitive Label-Free Optical BioMEMS Platform Based on a DBR-Michelson Interferometer for Cancer Detection and Therapeutic Applications

Bocar Ndiaye, Naima Brahiti, Kazem Nouri, Taha Azad et autres

Early detection of cancer remains challenging due to the extremely low concentration of biomarkers present during initial disease stages. Dysregulation of key signaling pathways, including cyclin-dependent kinase (CDK) networks, drives uncontrolled cell proliferation and tumor progression, underscoring the need for highly sensitive, …

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An 18-color spectral flow cytometry panel to characterize murine myeloid populations in oncolytic virus-treated tumors

Lauren Daniel, Mahsa Ahmadi, Jacob L. Léger, Nasser Hashemi Goradel et autres

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An 18-color spectral flow cytometry panel to characterize murine myeloid populations in oncolytic virus-treated tumors

Lauren Daniel, Mahsa Ahmadi, Jacob L. Léger, Nasser Hashemi Goradel et autres

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Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction

Zabih Mir Hassani, Frédérique Goulet, Duc Tai Nguyen, Anne-Marie Landry-Voyer et autres

Programmed cell death 2 (PDCD2) is an evolutionarily conserved protein essential for cell viability from yeast to humans. PDCD2 functions as a dedicated chaperone to the 40S ribosomal protein uS5, and loss of PDCD2 function impairs ribosome biogenesis. As cancer cells require …

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A Highly Sensitive Optical Biosensor with Tunable Point Defect Cavity for Point-of-Care Testing

Bahareh Firouzi, Yashar Gholami, Behnam Saghirzadeh Darki, Kian Jafari et autres

This paper introduces a surface stress-based BioMEMS sensor featuring an optomechanical detection system designed to measure the target bioparticles' concentration. The sensor incorporates a defective 2D photonic crystal along with a MEMS transducer. When the target bioparticles are absorbed by the bioreceptors …

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Artificial Intelligence Reveals Nature: Functional Parallels Between a Designed and a Natural Peptide

Jiashu Wang, Thomas David Daniel Kazmirchuk, Maryam Hajikarimlou, Mustafa Al‐gafari et autres

Natural peptides derived from plants have been an important source of medical substances for several decades. Due to their mechanism of action, chemical potential, and favourable side effect profile, these peptides represent a safer alternative to synthetic pharmaceutical treatments. In this study, …

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P3.03.38 Oncolytic Virus Effectively Delivers CD47 Blockade to Suppress Tumour Growth in Preclinical NSCLC Models

Rira Hoshi, A.P.Y. Lau, Gabriel St-Laurent, Mohammad Ahmadi et autres

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Abstract B003: Oncolytic VSVd51-LIGHT and folfirinox chemotherapy increases anti-tumor immune response in pancreatic ductal adenocarcinoma

Jacob L. Léger, Nawal Amhis, Sarah Mansouri, Maxime Léveillé et autres

Abstract The immunosuppressive tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is a major factor that limits the therapeutic effect of immunotherapy and chemotherapy in PDAC patients. A promising approach is the use of oncolytic viruses (OVs), particularly the vesicular stomatitis virus …

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An Ultrasensitive MOEMS Platform Relied on an Adjustable Defect Width for Label-Free Bioparticle Detection

Yashar Gholami, Behnam Saghirzadeh Darki, Mohammad Hossein Poorghadiri Isfahani, Kian Jafari et autres

This article presents a novel optomechanical surface stress-based biosensor. The proposed device employs a functionalized microelectromechanical systems (MEMS) transducer to capture the target bioparticles in the sample. The interaction of the bioreceptors immobilized on the transducer surface with the target bioparticles modifies …

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Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses

Reza Rezaei, Stephen Boulton, Mahsa Ahmadi, Julia Petryk et autres

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Alternative Strategies for Delivering Immunotherapeutics Targeting the PD-1/PD-L1 Immune Checkpoint in Cancer

Ryunosuke Hoshi, Kristyna A. Gorospe, Hagar I. Labouta, Taha Azad et autres

T cells activates downstream signaling pathways that culminate in T cell exhaustion and/or apoptosis. Physiologically, these immunosuppressive effects exist to prevent autoimmunity, but cancer cells exploit this pathway by overexpressing PD-L1 to facilitate immune escape. Intravenously (IV) administered immune checkpoint inhibitors (ICIs) …

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Oxidative stress‐induced YAP1 expression is regulated by NCE102 , CDA2 , and BCS1

Sarah Takallou, Maryam Hajikarimlou, Mustafa Al‐gafari, Jiashu Wang et autres

Maintaining cellular homeostasis in the face of stress conditions is vital for the overall well‐being of an organism. Reactive oxygen species (ROS) are among the most potent cellular stressors and can disrupt the internal redox balance, giving rise to oxidative stress. Elevated …

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