Zabih Mir Hassani

Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction

Zabih Mir Hassani, Frédérique Goulet, Duc Tai Nguyen, Anne-Marie Landry-Voyer et autres

Programmed cell death 2 (PDCD2) is an evolutionarily conserved protein essential for cell viability from yeast to humans. PDCD2 functions as a dedicated chaperone to the 40S ribosomal protein uS5, and loss of PDCD2 function impairs ribosome biogenesis. As cancer cells require …

ca (code pays fourni par la source)

A homozygous synonymous NOP58 variant causes a neurodevelopmental disorder by impairing maturation of pre-ribosomal RNAs

Loisa Dana Bonde, Tess Holling, Malik Alawi, Ahmed A. El Beheiry et autres

Ribosomes are ribonucleoproteins that are responsible for protein synthesis. They consist of ribosomal proteins and ribosomal RNAs (rRNAs). Pre-rRNAs are co-transcriptionally processed and chemically modified. The 2'-O-methylation of rRNAs is guided by box C/D small nucleolar ribonucleoprotein particles (snoRNPs), which are composed …

de, Égypte, ca (code pays fourni par la source)

Biallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss

Anne-Marie Landry-Voyer, Tess Holling, Emily Kathryn Mis, Zabih Mir Hassani et autres

Pregnancy loss is a major problem in clinical medicine with devastating consequences for families. Next generation sequencing has improved our ability to identify underlying molecular causes, though over half of all cases lack a clear etiology. Here, we began with clinical evaluation …

ca, gb, de, us (code pays fourni par la source)

Ribosomal Protein uS5 and Friends: Protein–Protein Interactions Involved in Ribosome Assembly and Beyond

Anne-Marie Landry-Voyer, Zabih Mir Hassani, Mariano Avino, François Bachand

Ribosomal proteins are fundamental components of the ribosomes in all living cells. The ribosomal protein uS5 (Rps2) is a stable component of the small ribosomal subunit within all three domains of life. In addition to its interactions with proximal ribosomal proteins and …

ca (code pays fourni par la source)

Combined application of cisplatin and salicylic acid suppresses cell growth and promotes apoptosis in human lung cancer cell lines

Seyyedeh Mahdokht Maddah, Golaleh Mostafavi, Mahlagha Amin Malek, Mohadese Anbarestani et autres

ir (code pays fourni par la source)

Melittin inhibits the expression of key genes involved in tumor microenvironment formation by suppressing HIF-1α signaling in breast cancer cells

Zabih Mir Hassani, Mohammad Nabiuni, Kazem Parivar, Somayeh Abdirad et autres

ir (code pays fourni par la source)

Melittin Inhibits the Expression of Key Genes Involved in Tumor Microenvironment Formation by Suppressing HIF-1α Signaling in Breast Cancer Cells

Zabih Mir Hassani, Mohammad Nabiuni, Kazem Parivar, Somayeh Abdirad et autres

ir (code pays fourni par la source)

Assessment of expression of vitamin D receptor-associated lncRNAs in gastric cancer

Tayabeh Salehnezhad, Fatemeh Hajati, Zabih Mir Hassani, Farbod Esfandi et autres

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Expression Analysis of the Long Non-Coding RNA LINC01433 in Lung Cancer

Zohreh Niazi, Ehsan Garazhian, Farbod Esfandi, Zabih Mir Hassani et autres

Background: Lung cancer is one of the most fatal human cancers both in males and females.This type of cancer is categorized to different subtypes among them is non-small cell lung cancer (NSCLC).NSCLC accounts for about 80% of all cases.Long non-coding RNAs (lncRNAs) …

ir (code pays fourni par la source)

Expression analysis of long non-coding RNAs GSTT1-AS1 and IFNG-AS1 and their target genes in lung cancer

Farbod Esf, Zabih Mir Hassani, Shahram Arsang‐Jang, Mohammad Naser Taheri et autres

Long non-coding RNAs (lncRNAs) have recently gained attention because of their regulatory roles on expression of genes involved in the immune response and cancer. In the present study, we evaluated expression of two lncRNAs (GSTT1-AS1 and IFNG-AS1) and their target genes (TNFA …