Andrey Coatrini Soares

Microfluidic Electronic Tongue Made with Nanostructured Films of Proteins from Renewable Sources to Detect H5N1 Antibodies from Avian Influenza Virus

Andrey Coatrini Soares, Juliana Coatrini Soares, Mário Popolin Neto, Gabriella Onila Nascimento Soares et autres

High Resolution Image Download MS PowerPoint Slide Avian influenza viruses, particularly the H5N1 subtype, represent a major global threat due to their high transmissibility and mortality rates. Rapid, low-cost, and reliable detection is essential for controlling viral spread in both avian and …

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Role of Local Treatment to the Prostate in Patients With de Novo Low-volume Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Receptor Pathway Inhibitors

Philipp C. Mandel, Mike Wenzel, Felix Chun, Markus Graefen et autres

Background and objective Local treatment (LT) to the prostate demonstrated better cancer-control outcomes in combination with androgen deprivation therapy (ADT) monotherapy for patients with low-volume metastatic hormone sensitive prostate cancer (mHSPC). However, the association of LT with outcomes in patients receiving ADT …

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Representation of Latin American oncologists in oral sessions at the ASCO Genitourinary Cancers symposium: A five-year review (2021–2025).

Daniel Vargas Pivato de Almeida, Federico Losco, Karine Martins da Trindade, Daniel Herchenhorn et autres

44 Background: Latin American (LATAM) investigators contribute substantially to global genitourinary (GU) cancer research through participation in multinational studies. However, their representation as speakers in leading international forums remains uncertain. This study evaluated LATAM participation as oral presenters and as co-authors of …

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Final overall survival results from the EORTC 1333/PEACE-3 trial: Enzalutamide with or without radium-223 in metastatic castration-resistant prostate cancer.

E. Gallardo, Bertrand F. Tombal, Ananya Choudhury, Fred Saad et autres

15 Background: In EORTC1333.PEACE-3 the combination of enzalutamide and radium-223 (ENZ/RAD) prolonged rPFS and OS (interim analysis) in patients with mCRPC with bone metastases, with a safety similar to that of each treatment alone, versus enzalutamide alone (ENZ). Here we report the …

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Liver metastases in advanced urothelial carcinoma (ARON-2): do pembrolizumab and avelumab make a difference in a poor-prognosis scenario?

Linda Cerbone, Giandomenico Roviello, Fabio Calabrò, Tarek Taha et autres

Background Over the past decade, the treatment landscape for metastatic urothelial carcinoma (mUC) has improved significantly with the introduction of immunotherapy, targeted agents, and antibody–drug conjugates. The median overall survival (mOS) reached 36.7 months in cisplatin-eligible and 25.6 months in cisplatin-ineligible patients …

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Supramolecular PDDA/PEDOT:PSS Biosensor for Early Pancreatic Cancer Detection via CA19-9: Clinical Validation on Human Blood Samples

Gabriella Onila Nascimento Soares, Andrey Coatrini Soares, Ronaldo Dias, Rafael Kemp et autres

Pancreatic cancer has one of the highest mortality rates, and early detection remains a challenge, significantly limiting therapeutic strategies. In this study, we present the clinical validation of a novel multilayered capacitance-based biosensor for early pancreatic cancer detection. Poly-(diallyldimethylammonium chloride) and (poly-(3,4-ethylenedioxythiophene):polystyrenesulfonate) …

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Machine learning-enhanced nanofiber systems: a new frontier in controlled drug release

Gabriella Onila Nascimento Soares, Vítor Hugo Bridi Dei Santi, Andrey Coatrini Soares, Diego Sousa et autres

The use of machine learning (ML) is reshaping the design and optimization of nanofiber-based drug delivery systems (N-DDS). Electrospun nanofibers offer high surface area, tunable porosity, and versatile drug encapsulation strategies, making them attractive for controlled release applications in multiple therapeutic areas. …

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Belzutifan monotherapy and combination therapies in renal cell carcinoma: a clinical trial perspective from the ARON working group

Concetta Calabrò, Francesco Ciccimarra, Alessandro Rizzo, Gerardo Cazzato et autres

INTRODUCTION: Several studies have identified Hypoxia-Inducible Factor 2-alpha (HIF-2α) as a key oncogenic driver in clear cell renal cell carcinoma (ccRCC). In this context, belzutifan emerges as an oral inhibitor of HIF-2α, that acts by blocking the heterodimerization of HIF-2α with HIF-1β, …

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Infusion-Related Reactions Among Cancer Patients Receiving Immune Checkpoint Inhibitors: The ARON-MOUSEION-013 Systematic Review and Meta-Analysis

Elsa Vitale, Alessandro Rizzo, Lorenza Maistrello, Omar Cauli et autres

Purpose: To investigate the incidence of Infusion-Related Reactions (IRRs) among cancer patients receiving Immune Checkpoint Inhibitors (ICIs) and immune-based combinations. Patients and Methods: The ARON-MOUSEION-013 was registered in PROSPERO (CRD420251018433). Observational, randomized and quasi-experimental studies were included in the present review, and …

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Time to metastasis as a prognostic factor in metastatic urothelial carcinoma: results from the ARON-2 study

Renate Pichler, Gerald Klinglmair, Kirstin Binz, Enrique Grande et autres

Metastatic urothelial carcinoma (mUC) may present with metastases at the time of initial diagnosis (synchronous) or develop them during follow-up (metachronous). The impact of the timing of metastasis on the outcome of mUC remains unclear. We aimed to evaluate overall survival (OS) …

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Decreased appetite in cancer patients treated with immune checkpoint inhibitors (ICIs): The MOUSEION-012 systematic review and meta-analysis

Elsa Vitale, Alessandro Rizzo, Lorenza Maistrello, Omar Cauli et autres

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Efficacy of Enfortumab Vedotin After Platinum Chemotherapy and Pembrolizumab in Metastatic Urothelial Carcinoma: A Multicenter Real-World Analysis of the ARON-2EV Cohort

Ondřej Fiala, Francesco Grillone, Kazutoshi Fujita, Enrique Grande et autres

Our results support the real-world efficacy of enfortumab vedotin (EV) in patients with metastatic urothelial carcinoma previously treated with platinum-based chemotherapy followed by pembrolizumab. We observed an association between prior pembrolizumab outcomes and subsequent EV efficacy. This suggests that prior immunotherapy outcomes …

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