Benjamin D. Medina

Clinical and Genomic Features and Prognostic Biomarkers of Oligometastatic Nonsmall Cell Lung Cancer

Rebecca A. Deek, Jongmyung Kim, Ritesh Kumar, Benjamin D. Medina et autres

INTRODUCTION: Treatment of metastatic disease is rapidly evolving with local therapies increasingly being used in patients with oligometastasis. Better personalization is needed to appropriate select patients for these interventions. We attempted to better understand clinical features and genomic features of oligometastatic nonsmall …

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Identification of Segmental Parenchymal Resection Margins: Left S9, 10 How I Do It

Su‐Bin Lee, Benjamin D. Medina, Ashley L. McCormack, Richard Lazzaro

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Genetic characteristics and clinical outcomes of driver mutant oligometastatic non small cell lung cancer treated with combination definitive chemoradiotherapy and targeted systemic therapy.

Matthew P. Deek, Eshan U. Patel, Benjamin D. Medina, Ioannis Kontopidis et autres

e20676 Background: Treatment of oligometastatic non-small cell lung cancer (omNSCLC) is evolving with increasing use of local therapies to consolidate disease. Our molecular understanding is also improving with better ability to target genetically identified driver mutations. In non-metastatic NSCLC, combined approaches of …

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Tracheobronchomalacia vs Excessive Dynamic Airway Collapse

Subin Lee, Benjamin D. Medina, Richard Lazzaro

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Characterizing a learning curve for robotic-assisted bronchoscopy: Analysis of skills acquisition in a high-volume academic center

Matthew J. Bott, Nicolas Toumbacaris, Kay See Tan, Bryan Husta et autres

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Figure S3 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

Viability of HG129 cells or T1 GIST cells after 24 hours of (A, B) human IL17a or (C, D) anti-human IL17Ra. Representative of 2 separate experiments with experimental groups in triplicate. Data represent mean ± SEM; p values were calculated using a …

Figure S4 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

(A) Prevalence of IL17A+ γδ T cells in the spleens of KitV558Δ/+ mice after vehicle or imatinib treatment for 1 week. (B) Relative expression of Il6 by PCR of bulk KitV558Δ/+ tumors after 1 week of vehicle or imatinib. (C) Tumor weight …

Figure S4 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

(A) Prevalence of IL17A+ γδ T cells in the spleens of KitV558Δ/+ mice after vehicle or imatinib treatment for 1 week. (B) Relative expression of Il6 by PCR of bulk KitV558Δ/+ tumors after 1 week of vehicle or imatinib. (C) Tumor weight …

Table S2 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

Notable Module 3 genes

Data from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

Abstract γδ T cells are a rare but potent subset of T cells with pleiotropic functions. They commonly reside within tumors but the response of γδ T cells to tyrosine kinase inhibition is unknown. To address this, we studied a genetically engineered …

Figure S2 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

Supplemental Figure S2. Relative expression on a per cell basis in KitV558Δ/+ tumors of (A) Trdv4 and (B) multiple genes known to be members of the SCART1+ γδ T cell phenotype. Dot plots represent scRNAseq data of γδ T cells from 6 …

Figure S3 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor

Mark S. Etherington, Andrew N. Hanna, Benjamin D. Medina, Mengyuan Liu et autres

Viability of HG129 cells or T1 GIST cells after 24 hours of (A, B) human IL17a or (C, D) anti-human IL17Ra. Representative of 2 separate experiments with experimental groups in triplicate. Data represent mean ± SEM; p values were calculated using a …