Accès ouvert
2026
article
OpenAlex
Kathryn Blake, Lindsay J. Hines, Michelle Liu, Rachel A. Myers et autres
Importance: The effectiveness of pharmacogenetics to guide prescribing of selective serotonin reuptake inhibitors (SSRIs) for depression remains unclear, despite the well-established association between SSRI pharmacokinetics and genetic variation. Objective: To determine whether pharmacogenetic-guided prescribing of SSRIs improves treatment response in patients with …
us, gb
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Accès ouvert
2026
article
OpenAlex
Michael T. Eadon, Kerri L. Cavanaugh, Lilin She, Kady-Ann Steen-Burrell et autres
Importance: Apolipoprotein L1 locus (APOL1) high-risk alleles are associated with incidence of chronic kidney disease (CKD) among people with African ancestry. Few studies have examined the effect of genetic return of results on blood pressure (BP) management and control. Objective: To determine …
us, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Larisa H. Cavallari, Rachel A. Myers, Hrishikesh Chakraborty, Todd C. Skaar et autres
Importance: Individuals with genetic variation that results in absent (poor metabolizers) or reduced (intermediate metabolizers) cytochrome P450 2D6 (CYP2D6) enzyme activity have lower concentrations of highly potent active metabolites of tramadol, hydrocodone, and codeine and are thus at increased risk for inadequate …
us, gb
(code pays fourni par la source)
2018
article
OpenAlex
Andrea Flores Burroughs, Sylvia Eluhu, Diva S. Whalen, J. Shawn Goodwin et autres
Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a basic leucine‐zipper transcription factor essential for cellular responses to oxidative stress. Degradation of Nrf2 in the cytoplasm, mediated by Keap1‐Cullin3/RING box 1 E3 ubiquitin ligase and the proteasome, is considered the primary pathway …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Andrea Flores Burroughs, Sylvia Eluhu, Diva S. Whalen, J. Shawn Goodwin et autres
BACKGROUND/AIMS: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine-zipper transcription factor essential for cellular responses to oxidative stress. Degradation of Nrf2 in the cytoplasm, mediated by Keap1-Cullin3/RING box1 (Cul3-Rbx1) E3 ubiquitin ligase and the proteasome, is considered the primary …
us
(code pays fourni par la source)