Pei-Yu Chu

Spatial transcriptomic profiling of ovarian clear cell carcinoma reveals heterogeneity in OXPHOS and EMT gradients

Thang Truong Le, Duncan Yi-Te Wang, Simin Yan, Yi-Cian Chen et autres

Intratumoral heterogeneity is intrinsically comprised of molecular alterations of tumor cells and extrinsically from interconnections with microenvironments. This study explores the spatial heterogeneity of ovarian clear cell carcinoma (OCCC), a rare cancer with significance to East Asian women. We profile 21 primary-metastatic …

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Study of the Stability of Quantum Dot Material Using ALD Encapsulation at Above-Room Temperatures for Mini-LED Applications

Y. C. Chen, Pei-Yu Chu, Y.T. Wang, Yun-Zhen Liu et autres

Development of vessel mimicking microfluidic device for studying mechano-response of endothelial cells

Pei-Yu Chu, Han‐Yun Hsieh, Pei‐Shan Chung, Pai-Wen Wang et autres

The objective of this study is to develop a device to mimic a microfluidic system of human arterial blood vessels. The device combines fluid shear stress (FSS) and cyclic stretch (CS), which are resulting from blood flow and blood pressure, respectively. The …

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Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies

Pei-Yu Chu, Angele Pei-Fern Koh, Jane Antony, Ruby Yun‐Ju Huang

A variety of in vivo experimental models have been established for the studies of human cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet the aspiration of precision medicine, the in vivomurine models have been widely adopted. …

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Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target

Pei-Yu Chu, Yuling Tai, Tang‐Long Shen

The partner of activated epidermal growth factor receptor (EGFR), growth factor receptor bound protein-7 (Grb7), a functionally multidomain adaptor protein, has been demonstrated to be a pivotal regulator for varied physiological and pathological processes by interacting with phospho-tyrosine-related signaling molecules to affect …

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Measurement of Poly(ethylene glycol) by Cell-Based Anti-poly(ethylene glycol) ELISA

Kuo‐Hsiang Chuang, Shey-Cherng Tzou, Ta-Chun Cheng, Chien-Han Kao et autres

Poly(ethylene glycol) (PEG) is increasingly used in clinical and experimental medicine. However, quantification of PEG and PEGylated small molecules remains laborious and unsatisfactory. In this report, we stably expressed a functional anti-PEG antibody on the surface of BALB 3T3 cells (3T3/alphaPEG cells) …

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