Kuo‐Hsiang Chuang

Engineered α9-nAChR-targeting antibodies attenuate nicotine-enhanced triple-negative breast cancer progression and exhibit favorable short-term tolerability in cynomolgus macaques

Chi‐Hsin Lee, Yi-Yuan Yang, Kuo‐Hsiang Chuang, Yu-Hsuan Lin et autres

Cigarette smoking and nicotine exposure promote breast cancer progression and poor outcomes by aberrantly activating nicotinic acetylcholine receptors (nAChRs), with α9-nAChR serving as a key oncogenic driver, especially in triple-negative breast cancer (TNBC). However, effective therapeutic strategies that directly target α9-nAChR remain …

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Corrigendum to: “A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth” [Cancer Lett. 648, (2026) 218463]

Yao‐Tsung Tsai, Min-Hsuan Yen, Ping-Jen Hu, Cheng-Chung Lee et autres

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A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth

Yao‐Tsung Tsai, Min-Hsuan Yen, Ping-Jen Hu, Cheng-Chung Lee et autres

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Combination of proton-pump inhibitor and anti-CD3 F(ab’)2 for islet neogenesis and immune modulation in type 1 diabetes

Tung-Yun Wu, Che-Yi Chen, M Y Chen, Chang-Hung Wang et autres

Abstract Introduction Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell–mediated destruction of pancreatic β cells. Current insulin therapy does not address autoimmune pathology or restore endogenous β-cell function, highlighting the need for disease-modifying strategies. Methods We developed a …

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Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery

Chi‐Yuan Chang, Li Xu, Yu-Han Lin, Cheng‐Liang Peng et autres

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Melatonin reverses bisphenol A-induced toxicity in granulosa cells: Restoration of FSHR and connexin 43 expression

Ta-Chin Lin, Kai‐Hung Wang, Kuo‐Hsiang Chuang, An-Pei Kao et autres

Objective Bisphenol A (BPA) is an estrogen-like endocrine-disrupting chemical commonly found in various daily consumer products. It causes female reproductive disorders by interfering with endocrine signaling. Normal folliculogenesis, oocyte maturation, ovulation, and luteal growth/involution rely on the gap junctional intercellular communication between …

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Development of a tumor-region-selective activation monoclonal antibody targeting the 4-1BB receptor for enhanced therapeutic efficacy and safety

Tzu‐Yi Liao, Yen-Ling Liu, Chiao-Yun Chen, Benjamin G. Wu et autres

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Short-Chain Dense Brush Pegylation on Rigid Nanocarriers Overcomes Anti-Peg Antibody Recognition for Immune-Stealth Drug Delivery

Ting-Yu Chen, Chi‐Yuan Chang, Xu Li, Cheng‐Liang Peng et autres

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Tumor Antigen-Tethered Spiked Virus-Like- Poly(Lactic-Co-Glycolic Acid)-Nanoparticle Vaccine Enhances Antitumor Ability Through Th9 Promotion in Mice

Ting-Wei Lin, Po-Yu Chou, Yen-Ting Shen, Ming‐Thau Sheu et autres

Purpose: Immunotherapy emerges as a promising frontier in cancer therapy and prevention. This study investigates the capacity of tumor-antigenic nanoparticles, specifically ovalbumin-tethered spiked virus-like poly(lactic-co-glycolic acid) nanoparticles (OVA-sVLNP), to effectively elicit humoral and cellular immune responses against tumors. Methods: OVA-sVLNP were synthesized …

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Abstract 4741: Targeting sorafenib-resistant HCCs by protein X-armed T cell immunotherapy

Mai-Huong Thi Ngo, Michael J. Chen, Pei‐Chi Lan, Kuo‐Hsiang Chuang et autres

Abstract Hepatocellular carcinoma (HCC) is the most common type of liver cancer globally, ranking fourth according to the World Health Organization's GLOBOCAN database. Sorafenib and lenvatinib are single-drug therapies used for advanced HCC, but only around 30% of patients benefit from them, …

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Celecoxib attenuates interleukin 33-induced expression of vascular cell adhesion molecule-1 in human ovarian endometriotic stromal cells

Ta-Chin Lin, Kai‐Hung Wang, Kuo‐Hsiang Chuang, An‐Pei Kao et autres

OBJECTIVE: Endometriosis is an estrogen-dependent chronic inflammatory disease in women of reproductive age. A review of the literature revealed that cytokines and inflammatory factors are associated with endometriosis-associated infertility. Interleukin 33 (IL-33) is a strong inducer of other pro-inflammatory cytokines. Vascular cell …

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A non-genetic engineering platform for rapidly generating and expanding cancer-specific armed T cells

Yi-Jou Chen, Michael J. Chen, Tian‐Lu Cheng, Yi‐Shan Tsai et autres

BACKGROUND: Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. However, the commercial production of cancer-specific T cells is often hampered by laborious cell culture procedures, the concern of retrovirus-based gene transfection, or insufficient T cell purity. METHODS: …

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