David G. McIntosh

Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer

Gianmarco Leone, Francesco Orlando, Peter Dutey‐Magni, Osvaldas Vainauskas et autres

This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection of androgen receptor (AR) gene alterations within the gene body and/or enhancer region.

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Application of a portable quadrupole mass spectrometer to carbon isotope analysis

David G. McIntosh

Isotope analysis was present at the birth of mass spectrometry and has since found application in a diverse array of fields including biology, medicine, archaeology, geology, chronology, forensics and environmental science. Quadrupole mass spectrometry (QMS) revolutionised chemical analysis by obviating bulky magnets, …

Commemorating Madison Grant in California State Parks

David G. McIntosh

A memorial in Prairie Creek Redwoods State Park in Northern California continued to honor the name of Madison Grant (1865–1937) until 2021. De Forest Grant (Madison’s younger brother), John D. Rockefeller Jr., the New York Zoological Society, and others dedicated the monument …

Enhancing asynchronous remote teaching during the COVID-19 pandemic

Naser Sedghi, David G. McIntosh, Ali Al Ataby, Valerio Selis et autres

Various synchronous and asynchronous remote teaching methods have been used worldwide during the COVID-19 pandemic in academia. In this work, we report the activities implemented to enhance asynchronous remote teaching and their impact on students’ experience and satisfaction. The activities, including split …

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Mutational landscape of gynecologic cancers identified by prospective clinical sequencing in a nationwide cancer network

Julian C. Schink, Ricardo H. Álvarez, Julia A. Elvin, Amber Moran et autres

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Mutational landscape of cervical cancer identified by prospective clinical sequencing in a nationwide cancer network.

Julian C. Schink, Ricardo H. Álvarez, Julia A. Elvin, Amber Moran et autres

e17022 Background: Tumor genomic profiling is a critical component of precision oncology allowing the detection of genomic alterations (GA) that have the potential to be targeted therapeutically. We present an analysis of comprehensive genomic profiling (CGP) of a large series of cervical …

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Effects of the source gap on transmission efficiency of a quadrupole mass spectrometer

M. Joseph, David G. McIntosh, John R. Gibson, Stephen Taylor

RATIONALE: Recent trends towards miniature and portable quadrupole mass spectrometry (QMS) entail challenges in instrumental sensitivity, which is influenced by 3D fringe field effects on ion transmission in the Quadrupole Mass Filter (QMF). The relationship of these effects with the gap from …

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Vaccines for travel and vaccines for adults: moving targets!

David G. McIntosh

This short review provides up-to-date information on vaccination problems for travelers and adults in general, including hepatitis B, meningococcal infection, rabies, yellow fever, measles. The article presents the general principles of approaches to vaccination with a focus on those diseases and potential …

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Second-harmonic generation imaging of collagen in ancient bone

Brian C. Thomas, David G. McIntosh, T. Fildes, Linda D. Smith et autres

Second-harmonic generation imaging (SHG) captures triple helical collagen molecules near tissue surfaces. Biomedical research routinely utilizes various imaging software packages to quantify SHG signals for collagen content and distribution estimates in modern tissue samples including bone. For the first time using SHG, …

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Impact of Pre-Matriculation Instruction on Student Acculturation and First-Year Academic Performance in Medical School

Angela Hairrell, Sherry Smith, David G. McIntosh, Diane E. Chico

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Simultaneous liver metastasectomy at operation for primary colorectal or gynecologic malignancy.

J. Jarrett Corley, Mary Kinney Corley, Christopher J. Lahr, David G. McIntosh et autres

BACKGROUND: Treatment of synchronous resectable colorectal liver metastases has traditionally involved a staged surgical approach. Specialized centers have demonstrated good results with simultaneous resection. We aim to report our outcomes at the University of Mississippi Medical Center (UMMC) with simultaneous liver metastasectomy …

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Infectious diseases and their prevention across the Seven Ages of Man Вакцинация в современном мире

E. Pérez David, Gwen C. McIntosh, Pirogov Russian, Russian Federation et autres

This paper will describe some important infectious diseases and their prevention, to illustrate the interconnectedness of people at different ages. The diseases of interest are congenital infections, bacterial meningitis, rotavirus and human papillomavirus, healthcare associated infections, and influenza. Vaccination of individuals in …