Accès ouvert
2026
article
OpenAlex
Marina Russo, Gianluca Conza, Caterina Claudia Lepre, Gabriele Martin et autres
Background: Osteoporosis (OP) is a chronic disease characterized by decreased bone mass and altered microarchitecture, leading to bone fragility and fracture risk. To date, although carbohydrate-binding proteins Galectins 1 and 3 (Gal-1/Gal-3) have been implicated in bone metabolism, inflammation and aging, their …
it, ro
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Accès ouvert
2026
article
OpenAlex
Francesco Maria Rosanio, Giulia Borgia, Elena Ferone, Adriano Braile et autres
BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a heterogeneous spectrum of developmental disorders and represent the leading cause of chronic kidney disease and end-stage renal disease in the pediatric population. Although imaging remains the cornerstone of diagnosis, its …
it
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Accès ouvert
2026
article
OpenAlex
Adriano Braile, Adriano Bani, Seyedeh Fatemeh Hosseininasab, Nicola Del Regno et autres
BACKGROUND: Osteoporosis is a complex disorder involving bone loss and muscle degeneration. Multi-omics technologies provide novel insights into its molecular mechanisms and may support biomarker discovery, patient stratification, and therapeutic development. OBJECTIVE: This scoping review aimed to synthesize current evidence on the …
it
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Accès ouvert
2025
article
OpenAlex
Antonio Bove, Adriano Braile, Sabrina Sirico, Nicola Orabona et autres
Background: Bone defects resulting from trauma, infection, or benign tumors pose major challenges in orthopedic surgery. Traditional approaches, such as autologous bone grafting, are limited by donor site morbidity and graft availability. CERAMENT™, a synthetic bone substitute composed of calcium sulfate and …
it
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Accès ouvert
2025
article
OpenAlex
Gianluca Conza, Adriano Braile, A Vittoria, Nicola Di Cristofaro et autres
BACKGROUND: Bone loss management is a tough challenge in orthopedic and trauma surgery that is generally treated using graft or substitute. Bone is the second most common transplanted tissue behind blood. Autologous bone graft represents the gold standard, while allograft is generally …
it, us
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Accès ouvert
2025
article
OpenAlex
Mariantonia Braile, Adriano Braile, Chiara Greggi, Virginia Veronica Visconti et autres
Background: Osteosarcopenic obesity (OSO) syndrome, also defined as osteosarcopenic adiposity (OSA), is characterized by the concurrent loss of bone and muscle mass, accompanied by excess fat, leading to reduced functionality and metabolic imbalances. Recent studies have highlighted the role of microRNAs (miRNAs) …
it, al
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Accès ouvert
2025
article
OpenAlex
Marina Russo, Caterina Claudia Lepre, Gianluca Conza, Nicoletta Tangredi et autres
BACKGROUND: Adipose-derived mesenchymal stem cell conditioned medium (ASC-CM) improved the viability and wound closure of human tenocytes (HTCN) exposed to high glucose (HG) by activating the transforming growth factor beta 1 (TGF-β1) pathway. OBJECTIVES: Since ASC-CM can also modulate microRNAs (miRNAs) in …
it
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Accès ouvert
2025
review
OpenAlex
Antonio Bove, Adriano Braile, Nicola Del Regno, Sabrina Sirico et autres
Background: Periprosthetic joint infections (PJIs) are a significant issue in joint replacement surgery patients, affecting results and mortality. Recent research focuses on developing hydrogels (HG) and antimicrobial coatings to reduce pressure injuries, with DAC™ HG showing lower infection risk in hip revision …
it
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Accès ouvert
2025
article
OpenAlex
Adriano Braile, Annalisa De Cicco, Sara Liguori, Vincenzo de Matteo et autres
Background: Recently, intra‐articular injection of mesenchymal stem cells (MSCs) had been proposed as a conservative treatment for hip osteoarthritis (HOA). Adipose tissue was demonstrated as a viable source of MSCs because of the high concentration of cells and the easy access to …
it
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2024
article
OpenAlex
Gianluca Conza, Adriano Braile, Giuseppe Iodice, Nicola DI CRISTOFARO et autres
Osteoarthritis (OA) is a condition with an enormous economic and social burden. Recent developments in the regenerative medicine field appear to be very promising thanks to the introduction and diffusion of new joint preserving strategies. Among these, the injections of mesenchymal stem …
it
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Accès ouvert
2024
article
OpenAlex
Annalisa Itro, Annalisa De Cicco, Gianluca Conza, Luca Schiavo et autres
Patellar fractures represent approximately 1% of all fractures and the pattern is influenced by the quality of the bone and the energy of the trauma. Transverse fractures are associated with extensor mechanism failure and interruption of joint congruence. Patellar fractures are generally …
it
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Accès ouvert
2024
article
OpenAlex
Maria Consiglia Trotta, Annalisa Itro, Caterina Claudia Lepre, Marina Russo et autres
Introduction: Diabetic tendinopathy is a common invalidating and challenging disease that may be treated using stem cells. However, the effects of adipose-derived mesenchymal stem cell conditioned medium (ASC-CM) in diabetic tendinopathy have never been explored. Objectives: The present study evaluated the effects …
it
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