Maria Walker

Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue

Ãsa Walberg, Anna Maria Reuss, Reihane Ziadlou, Céline Mamie et autres

Commensal bacteria play a crucial role in modulating human immune responses in the intestine. Under homeostatic conditions, the gut microbiota is tightly regulated by interactions with the mucosal immune system. However, colorectal cancer (CRC) is characterized by an imbalance in bacterial composition …

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Altered Crosstalk of Bacterial Lipopolysaccharide with Immune Cells in Colorectal Cancer Compared to Paired Adjacent Intestinal Tissue

Ãsa Walberg, Anna Maria Reuss, Reihane Ziadlou, Céline Mamie et autres

SUMMARY Commensal bacteria play a crucial role in modulating human immune responses in the intestine. Under homeostatic conditions, gut microbiota are tightly regulated by interactions with the mucosal immune system. However, colorectal cancer (CRC) is characterized by an imbalance in bacterial composition …

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Microbiome Modulation as a Strategy to Enhance Immunotherapy in Metastatic CRC 9079

Maria Walker, Claudia Gottier, Doris Poehlmann, Madita Determann et autres

Abstract Description Therapeutic advances in the treatment of metastatic colorectal cancer (CRC) remain challenging due to treatment resistance and poor patient outcomes, especially in advanced- stage disease. CRC is the second leading cause of cancer-related mortality worldwide, with metastases significantly worsening patient …

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Probiotic Administration Modulates Gut Microbiota and Suppresses Tumor Growth in Murine Models of Colorectal Cancer

Anna Niechcial, Marlene Schwarzfischer, Paulina Wawrzyniak, Madita Determann et autres

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide with limited treatment options for advanced disease stages. Growing evidence implicates the gut microbiota in CRC pathogenesis, prompting interest in probiotics as a potential therapeutic strategy. In this study, we evaluated …

OS-086-YI Protein tyrosine phosphatase non-receptor type 2 controls hepatic function of cytotoxic T cells in metabolic dysfunction-associated steatohepatitis

Madita Determann, Luise Linzmeier, Marlene Schwarzfischer, Anna Niechcial et autres

Universal hepatitis B screening in a high risk community.

Ivy Abraham, Jane Mccullough, Janet Golick, Kasandra Cadman et autres

244 Background: 2015 ASCO guidelines for Hepatitis B (HBV) screening in patients (pts) receiving chemotherapy recommend a risk-adaptive strategy considering patient and treatment-specific factors. The University of Illinois Cancer Center (UICC) is an academic center with largely underserved, minority and socioeconomically disadvantaged …

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Timely administration of antibiotics in febrile neutropenia per updated ASCO/IDSA guidelines.

Krishna Bilas Ghimire, Po‐Hung Lin, Irum Khan, Kasandra Cadman et autres

41 Background: Current ASCO guidelines for management of febrile neutropenia (FN) recommend initial antibiotic administration within one hour of triage, and initial assessment within 15 minutes of triage for patients presenting with FN within 6 weeks of chemotherapy. The University of Illinois …

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Effects of glucocorticoids on the growth of human fibrosarcoma cell line HT-1080.

Maria Walker, Chang‐Jin Lim, Tapas K. Das Gupta, Craig W. Beattie

The human fibrosarcoma cell line HT-1080 exhibits rapid growth following s.c. inoculation in 4-6-week-old male athymic mice. Cytosols from tumors carried in athymic mice bind glucocorticoid (Kd, 1.8 +/- 0.48 X 10(-8) M; Bmax, 240.5 +/- 35.3 fmol/mg cytosol protein, mean +/- …

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