Céline Mamie

Multiomics analysis dissects the molecular foundation of perianal fistulas associated with Crohn’s disease and of cryptoglandular origin

Céline Mamie, Daniela Cabalzar‐Wondberg, Matthias Turina, Marcin Wawrzyniak et autres

BACKGROUND AND OBJECTIVE: Perianal fistulas, either of cryptoglandular origin (CgF) or associated with Crohn's disease (CDF), have limited treatment options and pose a tremendous burden for affected patients. We recently showed that the epithelial-mesenchymal transition (EMT) contributes to CDF pathogenesis, but detailed …

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Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue

Ãsa Walberg, Anna Maria Reuss, Reihane Ziadlou, Céline Mamie et autres

Commensal bacteria play a crucial role in modulating human immune responses in the intestine. Under homeostatic conditions, the gut microbiota is tightly regulated by interactions with the mucosal immune system. However, colorectal cancer (CRC) is characterized by an imbalance in bacterial composition …

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Altered Crosstalk of Bacterial Lipopolysaccharide with Immune Cells in Colorectal Cancer Compared to Paired Adjacent Intestinal Tissue

Ãsa Walberg, Anna Maria Reuss, Reihane Ziadlou, Céline Mamie et autres

SUMMARY Commensal bacteria play a crucial role in modulating human immune responses in the intestine. Under homeostatic conditions, gut microbiota are tightly regulated by interactions with the mucosal immune system. However, colorectal cancer (CRC) is characterized by an imbalance in bacterial composition …

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Advances in the Pathogenesis of Crohn’s Disease-Associated Fistulas

Céline Mamie

More than half of the patients with Crohn’s disease (CD) will develop intestinal fistulas, a distressing complication affecting the quality of life of the patients. Nowadays there are no satisfying treatment options for perianal fistulas, the most common fistula type. Surgeries are …

Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease

Yasser Morsy, Ãsa Walberg, Paulina Wawrzyniak, Barbara Hubeli et autres

The involvement of the intestinal microbiome in the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC), is well-established. Bacteria interact with immune cells at sites of intestinal inflammation, but also in the CRC tumor microenvironment. We hypothesized that bacterial remnants …

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Intestinal epithelial PTPN23 is essential for gut barrier integrity and prevention of fatal bacterial translocation

Rocio Sanchez Alvarez, Ana Montalban-Arques, Yasser Morsy, Claudia Gottier et autres

Background and aims: Protein tyrosine phosphatase nonreceptor type 23 (PTPN23) regulates the internalization of growth factor receptors such as the epithelial growth factor receptor (EGFR). Given the crucial function of such receptors in intestinal epithelial cells (IECs), we assessed the involvement of …

Intestinal epithelial PTPN23 is essential for gut barrier integrity and prevention of fatal bacterial translocation

Rocio Sanchez Alvarez, Ana Montalban‐Arques, Yasser Morsy, Claudia Gottier et autres

BACKGROUND AND AIMS: Protein tyrosine phosphatase nonreceptor type 23 (PTPN23) regulates the internalization of growth factor receptors such as the epithelial growth factor receptor (EGFR). Given the crucial function of such receptors in intestinal epithelial cells (IECs), we assessed the involvement of …

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Novel transcriptomic panel identifies histologically active eosinophilic oesophagitis

Emilie Gueguen, Yasser Morsy, Céline Mamie, Alain Schoepfer et autres

Background and aims Eosinophilic oesophagitis (EoE) is characterised by symptoms of esophageal dysfunction and oesinophil tissue infiltration. The EoE Diagnostic Panel (EDP) can distinguish between active and non-active EoE using a set of 77 genes. Recently, the existence of distinct EoE variants …

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Deletion ofSmad7Ameliorates Intestinal Inflammation and Contributes to Fibrosis

Cordelia Schuler, Federica Foti, Leonie Perren, Céline Mamie et autres

BACKGROUND: Patients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of transforming growth factor (TGF)-β compared with non-IBD controls. SMAD7 negatively regulates TGF-β signaling. An earlier study aiming to target Smad7 showed a lack of clinical benefit. It remains unknown …

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pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis

Cheryl de Vallière, Jesús Cosín‐Roger, Katharina Baebler, Anja Schoepflin et autres

Local extracellular acidification occurs at sites of inflammation. Proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) responds to decreases in extracellular pH. Our previous studies show a role for OGR1 in the pathogenesis of mucosal inflammation, suggesting a link …

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MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model

Céline Mamie, R Brückner, Silvia Lang, Nahum Y. Shpigel et autres

Fistula treatment represents a major unmet medical need in the therapy of Crohn’s disease (CD). Current medical therapies, such as anti-TNF antibody treatments, are often insufficient and do not achieve permanent fistula closure. Previously published data point toward a critical role for …

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New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4

Bruce Weder, Fabian Schefer, Wouter T. van Haaften, Eleonora Patsenker et autres

BACKGROUND: Patients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of pH-sensing receptors compared with non-IBD controls. Acidification leads to angiogenesis and extracellular matrix remodeling. We aimed to determine the expression of pH-sensing G protein-coupled receptor 4 (GPR4) in fibrotic …

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