Miriam Kessi

Systematic Reviews and Meta-Analyses of the Use of Tocilizumab in Treating Central Nervous Diseases

Jing Peng, Miriam Kessi, Fei Yin, Lifen Yang

INTRODUCTION: To perform systematic reviews and meta-analyses on the use of the tocilizumab in the central nervous system (CNS) diseases. METHODS: A systematic search was carried out in the PubMed, Embase and Cochrane databases for all years until August 2025. RESULTS: The …

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Epidemiology of COVID-19 Control, Vaccine Development, and Public Health Communication: Insights from Post-Pandemic Africa

Olumuyiwa A. Bamgbade, Vera O. Onongaya, Timothy O. Bamgbade, Chantelle E. Clarke Webster et autres

Background: COVID-19 is a major public health concern, and epidemiology remains central to vaccine development, priority-setting, product testing, marketing strategy, equitable distribution, post-vaccination surveillance, and the interpretation of vaccine uptake and hesitancy. This research examined COVID-19 knowledge, vaccine uptake, vaccine hesitancy, and …

ca, gb, Nigéria, Tanzanie, Afrique du Sud, Kenya, Mozambique, Zambie, Rwanda (code pays fourni par la source)

Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies

Changning Xie, Fei Yin, Miriam Kessi, Jing Peng

OBJECTIVE: This systematic review aimed to summarize recent progress in precision medicine for all studied potassium gene variants related to epilepsy. It analyzed studies conducted in cell and animal models and in humans. METHODS: A comprehensive search was conducted on PubMed, Embase, …

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Ketamine Therapy for Chronic Pain Provides Added Benefits for Substance Misuse Therapy

Olumuyiwa A. Bamgbade, Olumide O. Asaolu, Daniel O. Bamgbade, Olajumoke O. Lawal et autres

Background: Chronic pain is complicated by comorbid substance misuse. This multifaceted problem increases the risks of polypharmacy, overdose, impaired driving, and avoidable emergency care. Methods: This is an observational study of a convenience sample of twenty adult chronic pain patients who underwent …

ca, Nigéria, Afrique du Sud, fi, am, Zambie, gb, Rwanda, Tanzanie, Cameroun (code pays fourni par la source)

The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkers

Baiyu Chen, Shimeng Chen, Juan Xiong, Miriam Kessi et autres

Background: This study aimed to identify metabolic signatures and potential biomarkers for global developmental delay (GDD) and intellectual disability (ID) using plasma metabolomics and lipidomics. The research sought to evaluate the feasibility of these methods for early identification and to explore the …

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Corticosteroid‐Refractory Juvenile Myasthenia Gravis: Treatment Responses and Prognosis in a Large Chinese Cohort

Miriam Kessi, T. Hu, Guoli Wang, Wen Zhang et autres

INTRODUCTION/AIMS: Some patients diagnosed with juvenile myasthenia gravis (JMG) have corticosteroid-refractory myasthenia gravis (CRMG). The aim of this study was to evaluate the biomarkers of corticosteroid (CS) responsiveness and refractoriness in children, and the overall prognosis of patients after receiving nonsteroidal immunosuppressants …

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Blockade of Interleukin-6 Receptor with Tocilizumab During the Acute Phase of Childhood Immune-Mediated Epilepsy can Lead to a Favorable Outcome - an Observational Study

Xiaolu Deng, Jielu Tan, Miriam Kessi, Zhanwei Zhang et autres

INTRODUCTION: To explore the role of tocilizumab in treating childhood immune-mediated epilepsy and determine the role of interleukin-6 (IL-6) in its pathogenesis. METHODS: We collected and analyzed clinical information of pediatric patients diagnosed with immune- mediated epilepsy and treated with tocilizumab at …

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Mitochondrial and lysosomal dysfunctions might be involved in the pathogenesis of the CACNA1A-related neurodevelopmental disorders according to in vitro studies

Miriam Kessi, Langui Pan, Baiyu Chen, Li Yang et autres

BACKGROUND: CACNA1A variants are associated with severe neurodevelopmental disorders (NDDs), but the underlying mechanisms remain unclear. Our goal was to investigate the molecular mechanisms through which these variants lead to intellectual disability (ID), autism spectrum disorder (ASD), epilepsy, and ataxia. METHODS: Clinical …

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GRIN2B-related neurodevelopmental disorders: genotype-phenotype correlations and therapeutic implications

Changning Xie, Miriam Kessi, Fangyun Liu, Fang Ping He et autres

BACKGROUND: Pathogenic variants in GRIN2B are predominantly associated with neurodevelopmental disorders (NDDs). However, our understanding of the genotype-phenotype correlations and the optimal treatment strategies is limited. METHODS: We collected clinical data of seven new patients from the Xiangya Hospital and conducted an …

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Functional characterization and in vitro pharmacological rescue of a novel KCNA2 variant associated with developmental and epileptic encephalopathy

Changning Xie, Miriam Kessi, Fang He, Fei Yin et autres

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Genetic etiologies of the infantile epileptic spasms syndrome: What do we know so far?

Miriam Kessi, Lifen Yang

This commentary is on the original article by Zhao et al. on pages 521–530 of this issue.

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Anti-GAD65 Antibodies Related Refractory Epilepsy Successfully Treated with Tocilizumab: A Case Report and Systematic Literature Review

Shimeng Chen, Miriam Kessi, Jie-lu Tan, Fang Ping He et autres

Background: Although anti-GAD65 related epilepsy is rare, it needs more attention because it is refractory to the conventional therapies, has poor outcome and high relapse rate. In this study, we intended to report the efficacy of tocilizumab in the treatment of anti-GAD65 …

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