Hongzhou Shang

Preparation and properties of folic acid-targeted pH-responsive drug-loaded micelles

Hua Ma, Zimeng Wang, Yajie Ding, Xiuhong Duan et autres

In this study, a polymeric micelles material was prepared for tumor-targeted drug delivery using folic acid (FA) as targeting ligand. The polymeric material was prepared through combination of FA-modified methoxy polyethylene glycol (mPEG) and D-α-vitamin E succinate (VES) by pH-sensitive acetal bond, …

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Construction of dual-responsive hydrogels based on naturally derived crotonic acid for controlled drug delivery

Yajie Ding, Hua Ma, Zechao Ji, Ruize Wang et autres

cn (code pays fourni par la source)

Discovery of Highly Potent and Selective IKZF2 Degraders for Cancer Immunotherapy

Yalei Wang, Zhenze Qi, Shiyang Sun, Ting Wei et autres

Immunosuppressive Tregs, regulated by IKZF2, facilitate tumor immune evasion and resistance to immune checkpoint therapies. Targeted IKZF2 degradation represents a promising strategy for the development of innovative cancer immunotherapeutics. Herein, we designed and synthesized a novel series of phthalazinone-based glutarimide derivatives, identifying …

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Preparation of Novel Humic Acid-Derived Graphene Oxide-Like Supported Pt–Co Bimetallic Catalyst for Hydrogenation and Hydrodeoxygenation of 5-Hydroxymethylfurfural

Xinyang Hao, Bohan Wu, Simeng Bian, Hongzhou Shang et autres

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Study on the recycling of ternary basic deep eutectic solvent pretreated corn Stover

Ying Zhan, Xuejiao Ma, Chen Liu, Xisheng Hu et autres

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Preparation and properties of konjac glucomannan/P(N-isopropylacrylamide-crotonic acid) hydrogel

Hua Ma, Cheng Ji, Hongzhou Shang, Lihua Liu et autres

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Preparation and characterization of DeSC modified using succinic anhydride

Wangda Lu, Yi‐Long Wu, Xuepeng Zhang, Xiaoran Sun et autres

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Preparation of pH/temperature smart response hydrogels P(DEA-AMPS-EGDMA) for controlled release of 5-fluorouracil

Yalei Wang, Qian Zhang, Ning Qiao, Lihua Liu et autres

cn (code pays fourni par la source)

Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers

Ting Wei, Shiyang Sun, Xiaotong Hu, Pengli Wei et autres

Abstract Immunomodulatory drugs (IMiDs) are widely utilized therapies in multiple hematological cancers; however, their clinical application is frequently constrained by drug resistance. Here, though screening of diverse cereblon (CRBN) binders, comprehensive structure–activity relationships (SAR) analyses and systematic degradation profiling, MGD-22, a potent …

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Construction and preparation process optimization of pH/redox dual-responsive mesoporous silica drug delivery system

Wangda Lu, Yi‐Long Wu, Xuepeng Zhang, Xiaoran Sun et autres

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Folate‐Modified Drug‐Carrying Micelles With pH ‐Responsiveness for Curcumin‐Targeted Delivery

Zimeng Wang, Handa Liu, Hua Ma, Xuepeng Zhang et autres

ABSTRACT A predrug delivery system combining tumor‐targeting and pH‐responsive features was synthesized using baicalin (BAI), polyethylene glycol (PEG), and folic acid (FA). BAI and PEG were linked via esterification to create pH‐sensitive ester bonds (COO) that facilitate drug release in acidic environments, …

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Advances in the study of polysaccharide-based hydrogel wound dressings

Yu Zhang, Ning Qiao, Lihua Liu, Hongzhou Shang et autres

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