Leonie Hoermann

Allocation of TSPO-PET signals to cellular and extracellular compartments in dependence of blood-brain barrier disruption in experimental glioblastoma

Leonie Hoermann, Fatma Burcu Şeker, Emanuel Joseph, Sabrina V. Kirchleitner et autres

Abstract Background Translocator protein (TSPO)-PET imaging facilitates monitoring of glioblastoma in preclinical models and patients. However, specificity of TSPO-PET signals remains to be investigated. In this study, we aimed to decipher exact contributions of cellular and extracellular compartments including the impact of …

Whole-body TSPO-PET reveals stage-dependent disruption of systemic immune organ interactions in glioblastoma

Gloria Mueller, Artem Zatcepin, Laura M. Bartos, Leonie Hoermann et autres

Abstract Purpose Strong expression of the 18 kDa translocator protein (TSPO) is observed in glioma and tumor-associated myeloid cells within the tumor microenvironment. However, TSPO expression also extends beyond the tumor and may reflect systemic immune regulation. We therefore assessed inter-organ associations …

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Transport vehicle–mediated TREM2 PET maps myeloid cells in the glioblastoma microenvironment

M. Brendel, Laura M. Bartos, Ruoqing Feng, K Mueller et autres

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Blood-Brain Barrier Penetrating Copper-64 TREM2 Antibody Enables Targeted PET Imaging of Tumor-Associated Immune Cells in Glioblastoma Mouse Models

M. Haertel, Rebecca Schaefer, Lea H. Kunze, Ha Eun Park et autres

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Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease

Lina Dinkel, Selina Hummel, Valerio Zenatti, Mariagiovanna Malara et autres

Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in the NPC1 gene, causing lipid accumulation within late endosomes/lysosomes and resulting in progressive neurodegeneration. Although microglial activation precedes neuronal loss, it remains elusive whether loss of …

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Figure 5 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

Contralateral hemispheres of SB28 glioblastoma mice indicate signatures of disease-associated myeloid cells and immunosuppression. A, Volcano plot highlights genes with significant upregulation and downregulation in the contralateral hemisphere of SB28 glioblastoma mice (red and blue, respectively) compared to sham. B, qPCR reveals …

Table 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

Characteristics of the cohort.

Figure 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

Elevated TSPO-PET signals in the non-lesional hemisphere of patients with glioblastoma. A, Patient selection process. Patients receiving TSPO-PET imaging at initial diagnosis of glioma were allocated. Patients with unilateral manifestation of glioblastoma (WHO IV; n = 41) or isocitrate dehydrogenase mutant astrocytoma …

Figure 3 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

Contralateral TSPO-PET signal elevation is associated with persisting epileptic seizures and worse overall survival. A, Contralateral TSPO-PET shows no quantitative difference between patients presenting with (n = 20) and without (n = 20) epileptic seizures at inital diagnosis (top). Significant increase of …

Figure 2 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

Contralateral TSPO-PET signal elevation is associated with tumor phenotype and localization. A and B, Correlation of contralateral TSPO-PET signals in patients with glioblastoma (n = 38) with the TSPO-PET signal of the tumor (A) and the tumor volume in TSPO-PET, FET-PET (B, …

Data from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

AbstractPurpose: Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in the brain of patients with glioblastoma have been …

Supplementary Data 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome

Laura M. Bartos, Stefanie Quach, Valerio Zenatti, Sabrina V. Kirchleitner et autres

Supplementary Figures 1, 2 Supplementary Tables 1 - 3 inlucing Representativeness of Study Participants" supplementary table (Supplementary Table 1)