Francesca Ungaro

Development and clinical evaluation of a nanoemulsion for buccal delivery of cannabis extract in refractory chronic pain

Alessandra Spirito, Romina Provenzano, Antonella Vitiello, Nicola Antonio Di Spirito et autres

Cannabinoid-based therapies have gained increasing attention for the management of chronic and treatment-resistant pain, although their clinical application is limited by the poor aqueous solubility and variable bioavailability of Δ9-tetrahydrocannabinol (THC). In this study, we developed and characterized a nanoemulsion (THC-NE) for …

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Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids

Susy Brusco, Ersilia Villano, Teresa Silvestri, Amar J. Azad et autres

Building on growing evidence that ionizable lipids improve RNA delivery, in this work, we developed ionizable lipid/poly(lactic-co-glycolic acid) hybrid nanoparticles (iLipid@PLGA hNPs), consisting in a PLGA core modified at surface with either 1,2-dioleoyloxy-3-dimethylaminopropane (DODMA), 1,2-dioleoyl-3-trimethylammonium-propane (DODAP), or the branched-tail proprietary amino lipid …

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Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation

Angela Della Sala, Valentina Sala, Cosmin Butnarasu, Laura Tasca et autres

Cyclic AMP (cAMP) signaling specificity relies on precise spatial regulation mediated by A-kinase anchoring proteins (AKAPs), which localize protein kinase A (PKA) within defined microdomains. Dysregulated AKAP signaling contributes to different pathologies, including chronic inflammatory airway diseases, making AKAP disruptors attractive therapeutic …

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Emulsion-Solvent diffusion in a double-chip microfluidic platform for scalable production of Lipid@PLGA nanoparticles delivering siRNA therapeutics

Ersilia Villano, Teresa Silvestri, Susy Brusco, Chiara Infolfi et autres

Scalable nanoparticle manufacturing remains a key bottleneck in the clinical translation of RNA-based nanomedicines. In this study, we demonstrate the successful adaptation of a conventional emulsion-solvent diffusion protocol into an automated microfluidic workflow, illustrating its potential for streamlined and scalable nanoparticle production. …

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Inhaled Administration of Therapeutic siRNA for Pulmonary Fibrosis: CD105 as a Novel Molecular Target

Erika Esposito, Chiara Indolfi, Susy Brusco, Ersilia Villano et autres

TGFβ1 and CD105, a component of its receptor complex, are key drivers of fibrosis. In this study, we investigated the role of TGFβ1/CD105 signaling and the efficacy of silencing CD105 to counteract the fibrotic process. We evaluated the safety and efficacy of …

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From biowaste to innovation: Development of composite nanoparticles from lignin-rich agricultural byproduct

Mariavittoria Verrillo, Antonella Vitiello, Antonio Giandonato Caporale, Tommaso Silvestri et autres

Transforming organic waste into valuable compounds supports the principles of a circular economy. Compost tea (CT) and humic substances (HS), derived from agri-food wastes, are a potential source of lignin, the most abundant plant-origin polymer characterized by several beneficial properties and potential …

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Harnessing HP-β-CD in zein edible coatings for enhanced sensitive fruits preservation

Antonella Vitiello, Ovidio Catanzano, Annarita Scognamiglio, Alfonso Gallo et autres

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Unveiling the role of poly(vinyl alcohol) in the production of mucus-penetrating PLGA nanoparticles

Pouria Savadi, Andrea Casale, Michele Roggia, Gemma Conte et autres

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VALIDATION OF SURGICAL MASKS DURING COVID19 EMERGENCY: ACTIVITIES AT THE UNIVERSITY OF NAPOLI FEDERICO II

Andrea D’Anna, Francesco Di Natale, Gianluigi De Falco, Ernesto Di Maio et autres

SUMMARY: During COVID-19 pandemic crisis, Italian Government has approved Law Decree no. 18 of 17 march 2020, in which art. 15 allows enterprises to produce, import and commercialize surgical masks notwithstanding the current rules of product certification. It is just required that …

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Harnessing Hp-Β-Cd in Zein Edible Coatings for Enhanced Food Preservation

Antonella Vitiello, Ovidio Catanzano, Gabriella Costabile, Francesca Ungaro et autres

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PEI‐Engineered Lipid@PLGA Hybrid Nanoparticles for Multimodal Delivery of Antigens and Immune Adjuvants to the Respiratory Mucosa

Susy Brusco, Gemma Conte, Annunziata Corteggio, Teresa Silvestri et autres

Antigen delivery via respiratory mucosal surfaces is an interesting needle-free option for vaccination. Nonetheless, it demands for the design of especially tailored formulations. Here, lipid/poly(lactic-co-glycolic) acid (PLGA) hybrid nanoparticles (hNPs) for the combined delivery of an antigen, ovalbumin (Ova), and an adjuvant, …

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Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy

Giuseppe Longobardi, Thomas L. Moore, Claudia Conte, Francesca Ungaro et autres

Polymeric nanoparticles (NPs), specifically those comprised of biodegradable and biocompatible polyesters, have been heralded as a game-changing drug delivery platform. In fact, poly(α-hydroxy acids) such as polylactide (PLA), poly(lactide-co-glycolide) (PLGA), and poly(ε-caprolactone) (PCL) have been heavily researched in the past three decades …

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