Aasia Kalsoom

Characterization of microbiome diversity and its association with healing outcomes in diabetic foot ulcer patients

Muhammad Shakil Khan, Aasia Kalsoom, Awais Altaf, Muhammad Sarwar et autres

Diabetic foot infections (DFIs) are complex, polymicrobial conditions that delay wound healing, increase the risk of lower limb amputation, and contribute to higher mortality among patients with diabetes mellitus. Traditional culture-based diagnostic methods often fail to identify the full diversity of wound-associated …

pk, es, ae (code pays fourni par la source)

Immunopharmacological and structural design of a polyprotein based multi epitope vaccine against Powassan virus

Aasia Kalsoom, Syed Hussain Abidi, Sohail Ameer Marwat, Ghulam Shabbir et autres

pk, sa, gr (code pays fourni par la source)

Assessment of Recent Knowledge, Attitude, and Practice Towards Antimicrobial Resistance and Their Consumption During COVID-19 in Balochistan

Mah Gul Summan, Aasia Kalsoom, Awais Altaf, Ghulam Shabbir

Antimicrobial resistance is one of the biggest problems across the world. This condition threatens the effectiveness of treatments against infectious diseases. Most people are less aware of the causes of antimicrobial resistance. The irrational use of antibiotics during the COVID era has …

pk (code pays fourni par la source)

Comparison of active site mutations at subsite + 2 of Anoxybacillus ayderensis A9 β-glucosidase for hydrolysis of pNPG and polydatin

Numan Saleh Zada, Ali Osman Beldüz, Abdulrahman H. Alessa, Halil İbrahim Güler et autres

β-glucosidase from Anoxybacillus ayderensis A9 (BglA9) is a potent enzyme for enzymatic hydrolysis of polydatin to resveratrol. Based on structural and bioinformatics analysis an area near + 2 subsite of the active site pocket of BglA9 was selected and single point mutations …

pk, tr, sa (code pays fourni par la source)

GC–MS analysis, molecular docking, and apoptotic-based cytotoxic effect of Caladium lindenii Madison extracts toward the HeLa cervical cancer cell line

Aasia Kalsoom, Awais Altaf, Muhammad Sarwar, Tahir Maqbool et autres

Utilizing medicinal plants and other natural resources to prevent different types of human cancers is the prime focus of attention. Cervical cancer in women ranks as the fourth most common type of malignancy. The current study used gas chromatography-mass spectrometry (GC–MS) to …

pk (code pays fourni par la source)

Gene expression and anticancer evaluation of Kigelia africana (Lam.) Benth. Extracts using MDA-MB-231 and MCF-7 cell lines

Aasia Kalsoom, Awais Altaf, Huma Sattar, Tahir Maqbool et autres

In recent years, a cancer research trend has shifted towards identifying novel therapeutic compounds from natural assets for the management of cancer. In this study, we aimed to assess the cytotoxic activity of Kigelia Africana (KA) extracts on breast cancer (MDA-MB-231 and …

pk, se (code pays fourni par la source)

In vitro antiproliferative potential of Cassia angustifolia extracts on HepG2 cells to combat liver cancer

Aasia Kalsoom, Awais Altaf, Muhammad Idrees Jilani, Huma Sattar et autres

Liver cancer is a terrifying disease with limited treatment options and is responsible for global health and economic burden. Most anticancer options have severe adverse effects, including non-specific modes of action that aggravate the challenges of exploring effective, safe, and economical therapeutic …

pk, us (code pays fourni par la source)

[Retracted] In Vitro Evaluation of Cytotoxic Potential of Caladium lindenii Extracts on Human Hepatocarcinoma HepG2 and Normal HEK293T Cell Lines

Aasia Kalsoom, Awais Altaf, Muhammad Ashraf, Muhammad Muddassir Ali et autres

Data regarding the therapeutic potential of Caladium lindenii ( C. lindenii ) are insufficient. It becomes more important to explore plants as an alternative or palliative therapeutics in deadly diseases around the globe. The current study was planned to explore C. lindenii …

pk, bg, se (code pays fourni par la source)

In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease

Mahmood Rasool, Arif Malik, Sulayman Waquar, Quratul Ain et autres

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by dementia, excessive acetylcholinesterase (AChE) activity, formation of neurotoxic amyloid plaque, and tau protein aggregation. Based on literature survey, we have shortlisted three important target proteins (AChE, COX2, and MMP8) implicated in the pathogenesis …

sa, pk, cn (code pays fourni par la source)