Ayako Aoki

Valid surrogate end-points in nonsmall cell lung cancer peri-operative systemic therapy trials: a systematic review

Kohei Somekawa, Nobuyuki Horita, Satoshi Nagaoka, Yukihito Kajita et autres

BACKGROUND: Recurrence-, progression-, disease- and event-free survival are often selected as the primary end-points for trials assessing peri-operative systemic therapy for nonsmall cell lung cancer (NSCLC). As overall survival (OS) has increased, these surrogates, which we hereafter collectively term "recurrence-/progression-free survivals (RPFS)", …

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Efficacy and safety of benralizumab in elderly patients with severe eosinophilic asthma

Kohei Somekawa, Keisuke Watanabe, Kenichi Seki, Suguru Muraoka et autres

Background Biologics are the important drugs for severe asthma, but clinical trials included few elderly patients. Data on the safety and efficacy of benralizumab in elderly asthma patients are limited.Methods This clinical study was a multicentre, retrospective, observational study at two hospitals. …

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Geographic and economic influences on benralizumab prescribing for severe asthma in Japan

Nobuaki Kobayashi, Hiromi Matsumoto, Kohei Somekawa, Ayami Kaneko et autres

Benralizumab, a monoclonal antibody targeting IL-5 receptors, reduces exacerbations and oral corticosteroid requirements for severe, uncontrolled eosinophilic asthma. In Japan, geographic disparities in asthma outcomes suggest differential prescribing and access. This study aimed to quantify regional prescribing variations for benralizumab nationwide. Using …

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HLA‐DQA1*01:03 and DQB1*06:01 are risk factors for severe COVID‐19 pneumonia

Katsushi Tanaka, Akira Meguro, Yu Hara, L.M. Endo et autres

The clinical spectrum of COVID‐19 includes a wide range of manifestations, from mild symptoms to severe pneumonia. HLA system plays a pivotal role in immune responses to infectious diseases. The purpose of our study was to investigate the association between HLA and …

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Improved diagnostic accuracy with three lung tumor markers compared to six-marker panel

Ami Izawa, Yu Hara, Nobuyuki Horita, Suguru Muraoka et autres

Background: Combining multiple tumor markers increases sensitivity for lung cancer diagnosis in the cost of false positive. However, some would like to check as many as tumor markers in the fear of missing cancer. We though to propose a panel of fewer …

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Whole-Genome Sequencing Predicting Phenotypic Antitubercular Drug Resistance: Meta-analysis

Yoichi Tagami, Nobuyuki Horita, Megumi Kaneko, Suguru Muraoka et autres

BACKGROUND: For simultaneous prediction of phenotypic drug susceptibility test (pDST) for multiple antituberculosis drugs, the whole genome sequencing (WGS) data can be analyzed using either a catalog-based approach, wherein 1 causative mutation suggests resistance, (eg, World Health Organization catalog) or noncatalog-based approach …

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The clinical impact of comorbidities among patients with idiopathic pulmonary fibrosis undergoing anti-fibrotic treatment: A multicenter retrospective observational study

Ayako Aoki, Yu Hara, Hiroaki Fujii, Kota Murohashi et autres

BACKGROUND: Among patients with idiopathic pulmonary fibrosis (IPF), few studies have investigated the clinical impact of anti-fibrotic treatment (AFT) with and without comorbidities. The aim of the study was to determine whether Charlson Comorbidity Index score (CCIS) can predict the efficacy of …

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＜Editors' Choice＞ Comparison of clinical features between patients with acute exacerbation of idiopathic interstitial pneumonia and collagen vascular disease-associated interstitial pneumonia.

Yuki Kata, Yu Hara, Kota Murohashi, Yusuke Saigusa et autres

Acute exacerbation (AE) of interstitial pneumonia (IP) shows poor prognosis, due to the typical histological pattern of diffuse alveolar damage superimposed upon lung fibrosis. The previous reports comparing clinical features between AE of idiopathic interstitial pneumonias (IIPs) and those of IPs with …

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ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease

Hiroaki Fujii, Yu Hara, Yusuke Saigusa, Yoichi Tagami et autres

Background. The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-GAPC) to predict ILD prognosis was investigated. …

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Adverse events induced by durvalumab and tremelimumab combination regimens: a systematic review and meta-analysis

Hiromi Matsumoto, Kohei Somekawa, Nobuyuki Horita, Suguru Ueda et autres

Background: Immune checkpoint inhibitors (ICIs) have shown remarkable therapeutic outcomes among cancer patients. Durvalumab plus tremelimumab (DT) is under investigation as a new ICI combination therapy, and its efficacy has been reported in various types of cancer. However, the safety profile of …

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Supplementary Material for: Effect of benralizumab on mucus plugs in severe eosinophilic asthma

Nobuyuki Sakai, Toshiyuki Koya, Yasutaka Murai, Fumito Tsubokawa et autres

Introduction: Mucus plugs are associated with airway obstruction in severe asthma and are involved in the formation of activated eosinophils. Benralizumab, an anti-interleukin-5 receptor antibody, markedly reduces not only peripheral blood eosinophils but also airway eosinophils; however, its effects on mucus plugs …

ILD-GAP combined with the Charlson Comorbidity Index score (ILD-GAPC) as a prognostic prediction model in patients with idiopathic pulmonary fibrosis, idiopathic nonspecific interstitial pneumonia, and collagen vascular disease-related interstitial pneumonia

Hiroaki Fujii, Yu Hara, Yusuke Saigusa, Yoichi Tagami et autres

Abstract BackgroundThe ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-GAPC) to predict ILD prognosis was investigated.MethodsIn …

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