2025
article
OpenAlex
Rose Bahari, Lawrence W. Miller, Hyatt Alaraj, Archit Agnihotri et autres
e21605 Background: Melanoma is among the deadliest skin cancers, responsible for an estimated 7,990 annual deaths. Telomerase binds to the 3' overhang of telomeres, enabling elongation and cell survival. T-oligo, a guanine-rich oligonucleotide homologous to the telomere overhang, targets this 3' region, …
us
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Accès ouvert
2025
conference-abstract
OpenAlex
Hyatt Alaraj, Mark D. McCauley, Lawrence W. Miller
us
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2025
conference-abstract
OpenAlex
Rose Bahari, Stephanie M. Lopez, Archit Agnihotri, Hyatt Alaraj et autres
Abstract Melanoma is one of the deadliest skin cancers in the world, estimated to cause 7, 990 deaths annually. Telomerase binds to the 3' overhang of the telomere, causing telomere elongation and cell survival. Treatment against melanoma aims at targeting the 3' …
us
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Accès ouvert
2025
article
OpenAlex
Benjamin Sreenan, Vala Kafil, Donovan Wells, Gita Kharal et autres
us, cn
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2023
editorial
OpenAlex
Paula Gawryszewska, Lawrence W. Miller, Artur J. M. Valente
EDITORIAL article Front. Chem., 08 August 2023Sec. Inorganic Chemistry Volume 11 - 2023 | https://doi.org/10.3389/fchem.2023.1258607
pl, us, pt
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2023
conference-abstract
OpenAlex
Archit Agnihotri, Taylor Rager, Kelly D. Fan, Hyatt Alaraj et autres
Abstract Telomeres have become an attractive target for anticancer therapeutics and in 2022, an estimated 99,780 new cases and 7,650 people are expected to die of melanoma. T-oligo, a hexanucleotide tandem repeat oligonucleotide that is homologous to the 3′ overhang of telomeres …
us
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2022
article
OpenAlex
Ha T. T. Pham, Mona Hoseini Soflaee, Andrei V. Karginov, Lawrence W. Miller
Genetically encoded, Förster resonance energy transfer (FRET) biosensors enable live-cell optical imaging of signaling molecules. Small conformational changes often limit the dynamic range of biosensors that combine fluorescent proteins (FPs) and sensing domains into a single polypeptide. To address this, we developed …
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Accès ouvert
2021
preprint
OpenAlex
Ha T. T. Pham, Mona Hoseini Soflaee, Andrei V. Karginov, Lawrence W. Miller
ABSTRACT Rac1 is a key regulator of several cell signaling pathways and dysregulated Rac1 activation has been implicated in cancer. Genetically encoded Förster resonance energy transfer (FRET) biosensors with enhanced dynamic range enabled live cell fluorescence imaging of Rac1 activity and a …
us
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2021
book-chapter
OpenAlex
Ha T. T. Pham, Lawrence W. Miller
us
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Accès ouvert
2020
article
OpenAlex
Ting Chen, Ha T. T. Pham, Ali Mohamadi, Lawrence W. Miller
Lanthanide-based, Förster resonance energy transfer (LRET) biosensors enabled sensitive, time-gated luminescence (TGL) imaging or multiwell plate analysis of protein-protein interactions (PPIs) in living cells. We prepared stable cell lines that expressed polypeptides composed of an alpha helical linker flanked by a Tb(III) …
us
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2020
other
OpenAlex
Ha T. T. Pham, Lawrence W. Miller
2020
other
OpenAlex
Ha T. T. Pham, Lawrence W. Miller