Jeffrey A. Herron

Movement-responsive deep brain stimulation reinforces motor circuits in Parkinson’s disease

Daryl J Lawrence, Jiyeon Suh, Victoria Chang, Jeffrey A. Herron et autres

Abstract Deep brain stimulation is an established treatment for Parkinson’s disease but does not adapt to dynamic changes in brain state. Here, in four patients with sensing-enabled DBS systems, we evaluated a movement-responsive DBS (mDBS) paradigm that modulated subthalamic stimulation based on …

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Digital Markers for Passive Remote Monitoring of Bipolar Disorder: Systematic Review

Thomas P. Kutcher, Isha Chakraborty, Kristin M. Kostick, Akane Sano et autres

Background: Bipolar disorder (BD) features episodic shifts among mania, hypomania, depression, mixed states, and euthymia. Timely detection of mood transitions is difficult due to infrequent clinical touchpoints. Digital health technologies, including wearables and smartphones, offer a unique opportunity to passively and continuously …

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Author Correction: Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation

Jeffrey A. Herron, F. Aura Kullmann, Timothy Denison, Wayne K. Goodman et autres

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Real-Time Kinematic Adaptive Deep Brain Stimulation Safely Reduces Gait Impairment and Freezing of Gait in Parkinson’s Disease

Shreesh Karjagi, Yasmine M. Kehnemouyi, Matthew N. Petrucci, Laura Parisi et autres

Abstract Gait impairment (GI) and freezing of gait (FOG) affect 80% of patients with advanced Parkinson’s disease. Continuous deep brain stimulation (cDBS) provides limited adaptability to address the episodic nature of FOG due to fixed parameters. Neural biomarkers for adaptive DBS are …

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Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development

F. Lampert, Matthew Baker, Michael A. Jensen, Amir Hossein Ayyoubi et autres

Adaptive neuromodulation systems and implantable brain-computer interfaces have made notable strides in recent years, translating experimental prototypes into clinical applications and garnering substantial attention from the public. This surge in interest is accompanied by increased scrutiny related to the safety, efficacy, and …

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DBS Data Synchronization with Continuous Audio and Video for Psychiatric Biomarker Discovery

Maria Agustina Amilibia, Raphael Bechtold, Wayne K. Goodman, Sameer A. Sheth et autres

Introduction: Obsessive-compulsive disorder (OCD) and treatment-resistant bipolar depression (TRBD) constitute some of the most challenging psychiatric disorders to treat, as a significant proportion of patients demonstrate poor response to pharmacological strategies alone or in combination with psychoterapeutic approaches.1 Deep brain stimulation (DBS) …

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NDX-Wearables: An NWB Extension for Clinical Neuroscience

Tomasz M. Fra̧czek, Nicole Guittari, Rick R. Hanish, Timon Merk et autres

Data sharing is an increasingly essential component of clinical research, especially in the context of neuroscience, where research teams are often large, multidisciplinary collaborations. A critical component of effective data sharing is a common standard for data exchange, which supports both sharing …

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Developing a Distributed Kinematic and Neural Deep Brain Stimulation Hybrid Controller for Parkinson's Disease

Pranav Akella, Annie K Abay, Kevin B. Wilkins, Matthew N. Petrucci et autres

Neural adaptive deep brain stimulation (NaDBS) using beta band power as a biomarker is currently being investigated as a therapy for Parkinson's disease (PD). These systems modulate DBS amplitude in response to beta power fluctuations resulting from medication use or the underlying …

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An Open-Source Solution for Prolonged Neural Streaming from Bidirectional Deep Brain Stimulation Devices

Kasra Mansourian, Tomasz M. Frączek, Thomas P. Kutcher, Jonathan H. Bentley et autres

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Artifact Identification and Mitigation Strategies for Longitudinal Neural Data Collection Onboard the Medtronic Percept DBS Device

Rick R. Hanish, Thomas P. Kutcher, Tomasz M. Frączek, Raphael Bechtold et autres

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Designing a Data Collection Infrastructure: Challenges and Solutions in Recording-Enabled DBS Research for Psychiatric Disorders

Raphael Bechtold, Kasra Mansourian, Holden Bentley, Sameer A. Sheth et autres

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Characterization of beat frequency artifacts in dual-device deep brain stimulation

Nabeel Diab, Kara N. Presbrey, Stephanie Cernera, Sameer Rajesh et autres

Abstract Objective Recording-capable deep brain stimulation systems enable chronic monitoring of neural activity concurrently with stimulation. DBS configurations with two implantable pulse generators (IPGs) are becoming more common to increase the number of sensing and stimulating channels. However, even when both IPGs …

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