Rita Businaro

AgeViva Modulates Inflammatory Responses, Autophagy, and Mitochondrial Homeostasis in BV-2 Cells and C. elegans

Federica Armeli, Emily Schifano, Beatrice Mengoni, Arianna Montanari et autres

Background: Oxidative stress, neuroinflammation, impaired autophagy, and mitochondrial dysfunction are major contributors to ageing and neurodegenerative diseases. This study investigated whether AgeViva could counteract these processes by modulating redox balance, inflammation, autophagy, and mitochondrial function. Methods: The effects of AgeViva were evaluated …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Vincenza Rita Lo Vasco, Martina Leopizzi, G Azzara, Carina E. Cannizzaro et autres

During inflammation, endothelial cells (EC) are the first elements to be exposed to mediators circulating in the bloodstream. EC react with finely tuned responses mediated by different pathways, including the Phosphoinositide (PI) signal transduction system. The PI pathway contributes to a variety …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Rita Businaro, Andrea Fuso, Giovanni Laviola, Gabriella Azzara et autres

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with onset in the first 3 years of life, with an incidence in Italy of 6–10 new cases per 10,000 children per year. Affected children show impaired social interactions, repetitive or stereotypical behaviors and …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Gabriella Azzara, Cristina Cannizzaro, Mariangela Corsi, Serafino Ricci et autres

The rationale of our study was to test the potential of the autologous elements of peripheral white blood cells and platelets to promote neoangiogenesis, thereby overcoming hypoxemia, the major obstacle to the regeneration of the tissue. An highly innovative technique, based on …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Rita Businaro, Gabriella Azzara, Cristina Cannizzaro, Mariangela Corsi et autres

Much recent experimental evidence suggests that inflammatory reactions are involved in aneurysm formation and progression [1]. Vessel wall weakening has been attributed to the infiltration of a variety of cells, which leads to the upregulation of multiple cytokines [2]. A growing interest …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Stefano Ciaurelli, Rita Businaro

The skeletal muscle renin-angiotensin system (RAS) plays an important role in exercise metabolism. A functional insertion (I)/deletion (D) polymorphism in the angiotensin I- converting enzyme (ACE) gene (rs4646994) has been associated with ACE activity. The ACE DD genotype is associated with increased …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Tania Di Raimo, Mariangela Corsi, Rachele Riganò, Ilia J. Elenkov et autres

Macrophages are key cellular mediators of innate immunity: they are positionally and transcriptionally programmed to respond to pathogens and environmental challenges. When activated by inflammatory signals in their microenvironment they develop into functionally and phenotypically distinct polarized subpopulations: classically activated macrophages, M1, …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Tania Di Raimo, Rita Businaro, Martina Leopizzi, Carlo Della Rocca et autres

The phenotypic and functional diversity of macrophages depends on differentiating programs being developed during the cells’ lives. Great interest was addressed to identify the signal transduction pathways acting in macrophage polarization, including the phosphoinositide (PI) system and related phospholipase C (PLC) family …

Reply to Franzini et al. The Translational Medicine Regarding Ozone in Saline Solutions. Comment on “Armeli et al. Ozone Saline Solution Polarizes Microglial Cells Towards an Anti-Inflammatory Phenotype. Molecules 2025, 30, 3932”

Federica Armeli, Beatrice Mengoni, Martina Menin, Gregorio Martı́nez-Sánchez et autres

In this Reply, we address the criticisms raised by Franzini, Valdenassi, and Chirumbolo concerning our study on the effects of ozonized saline solution (O3SS) on microglial polarization and endothelial responses in vitro. We clarify that the primary aim of the original work …

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Supercritical CO2-Derived Tomato Extract Activates Signaling Pathways to Reduce Oxidative Stress and Inflammation in Astrocyte Cells

Serena Recalchi, Beatrice Mengoni, Barbara Scaglia, Marilena Esposito et autres

Background/Objectives: In this study, we investigated the effect on antioxidant defenses of a tomato extract obtained by supercritical CO2 extraction (sCO2TE), evaluating whether this green extraction method preserves biological activity compared to a conventional tomato extract (CTE) and focusing on superoxide dismutase …

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Increased Incidence of Alzheimer’s Disease: Lifestyle and Supplementation with Nutraceuticals and Probiotics as New Prevention and Treatment Strategies

Rita Businaro, Serafino Ricci

Alzheimer’s disease is a neurodegenerative disorder that mainly affects individuals over the age of 60, progressively rendering them unable to care for themselves. The incidence of the disease has increased dramatically in recent decades, posing a significant challenge to healthcare systems worldwide. …

Resveratrol, Curcumin, and Carotenoids in Nrf2 Activation: Molecular Mechanisms and Potential Role for the Treatment of Neurodegenerative Diseases

Federica Armeli, Beatrice Mengoni, Maria Luisa Crudeli, Martina Menin et autres

Neurodegenerative diseases represent a growing global challenge linked to aging, sharing core pathogenic mechanisms such as oxidative stress, neuroinflammation, and mitochondrial decay. This review evaluates the neuroprotective potential of specific polyphenols and carotenoids in modulating key signaling pathways. These nutraceuticals promote the …

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