Amie Rossi

Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of lumbar laminectomy and open durotomy compared with the gelatin-thrombin hemostatic matrix and control

Amie Rossi, Kasia Bradbury, Kingsley Abode-Iyamah, Angela Bohnen et autres

Background: Effective hemostasis in spinal surgery is critical, especially near sensitive structures such as the spinal cord and dorsal root ganglia. Flowable hemostatic agents offer targeted control in irregular, hard-to-reach areas. This study evaluates the safety and efficacy of flowable collagen hemostat …

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Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of craniectomy with intraparenchymal defect compared to gelatin-thrombin hemostatic matrix

Darcy H. Gagne, Kasia Bradbury, Angela Bohnen, Kingsley O. Abode-Iyamah et autres

Flowable hemostatic agents offer advantages in confined surgical spaces, particularly in neurosurgery. However, data on microfibrillar collagen hemostats (MCH) in these applications remain limited. This study evaluated the safety and efficacy of a novel flowable collagen and compared to a gelatin-thrombin matrix—in …

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor

Christopher R. Butler, Michael Popiolek, Laura A. McAllister, Erik LaChapelle et autres

Selective activation of the M 4 muscarinic acetylcholine receptor subtype offers a novel strategy for the treatment of psychosis in multiple neurological disorders. Although the development of traditional muscarinic activators has been stymied due to pan-receptor activation, muscarinic receptor subtype selectivity can …

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α5 nAChR modulation of the prefrontal cortex makes attention resilient

William M. Howe, Julie L. Brooks, Patrick L. Tierney, Jincheng Pang et autres

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[P3–046]: NOVEL NON‐CATECHOL D1 RECEPTOR AGONISTS EXHIBIT SUSTAINED PHARMACOLOGICAL ACTIVITY

Patrick L. Tierney, John Allen, Dmitri Volfson, Susan M. Lotarski et autres

Increasing evidence associates dysfunctional dopamine signaling with the motor and cognitive deficits in Alzheimer's disease. While D1 receptor (D1R) specific pathologies are reported, current D1R compounds have limited therapeutic potential due to their poor CNS penetration, negligible oral bioavailability, rapid metabolism and …

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α5 nAChR modulation of the effects of nicotine on ventral-striatal DA release and cue-reward learning

William M. Howe, Patrick L. Tierney, Amie Rossi, Damon A. Young et autres

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Imidazoline Derivatives with Antiarrhythmic Activity

Lincoln H. Werner, S. Ricca, Amie Rossi, George deStevens

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImidazoline Derivatives with Antiarrhythmic ActivityL. H. Werner, S. Ricca, A. Rossi, and George. deStevensCite this: J. Med. Chem. 1967, 10, 4, 575–582Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/jm00316a014https://doi.org/10.1021/jm00316a014research-articleACS PublicationsRequest reuse permissionsArticle Views235Altmetric-Citations21LEARN …