Wenyu Xi

Aspirin alleviates long-term high-fat diet-induced depressive-like behavior in male mice via suppressing arachidonic acid-mediated microglial activation and neuroinflammation

Binbin Zhao, Yajuan Fan, Qingyan Ma, Jinyu Zhang et autres

While Western dietary patterns are increasingly linked to neuropsychiatric disorders, the causal mechanisms by which chronic high-fat diet (HFD) contributes to depression remain elusive. Here, we demonstrate that prolonged ( ≥ 10 weeks) HFD exposure in mice robustly induces depressive-like behaviors, phenocopying …

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Gut microbiota reshapes host energy metabolism to modulate depressive behaviors

Pu Lei, Zhiyang Qi, Qingyan Ma, Binbin Zhao et autres

Disturbances in energy metabolism are a key pathophysiological feature of major depressive disorder (MDD). The gut microbiota, as a critical regulator of host metabolism, may influence systemic energy homeostasis and contribute to depression. To investigate this, we performed a multi-omics analysis integrating …

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Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Binbin Zhao, Min Jia, Yan Zhao, Lu Ye et autres

Major depressive disorder (MDD) is a critical psychiatric illness with significant societal implications. The exact molecular mechanisms underlying MDD, specifically concerning cellular iron metabolism and ferroptosis, remain inadequately characterized. This study explores the regulatory function of astrocytic ferroptosis and its linkage to …

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Association of Objective and Self‐Reported Sleep Duration With All‐Cause and Cardiovascular Disease Mortality: A Community‐Based Study

Binbin Zhao, Yuxuan Meng, Xiaoying Jin, Wenyu Xi et autres

Background Previous studies found an association between self-reported sleep duration and mortality. This study aimed to compare the effects of objective and self-reported sleep duration on all-cause and cardiovascular disease (CVD) mortality. Methods and Results A total of 2341 men and 2686 …

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Characterizing serum amino acids in schizophrenic patients: Correlations with gut microbes

Qingyan Ma, Fengjie Gao, Lina Zhou, Yajuan Fan et autres

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Sleep Efficiency May Predict Depression in a Large Population-Based Study

Bin Yan, Binbin Zhao, Xiaoying Jin, Wenyu Xi et autres

Objectives: The purpose of our study was to investigate the effect of objective sleep characteristics on the incidence of depression. Methods The participants of our study (1,595 men and 1,780 women with 63.1 ± 10.7 years) were selected from the Sleep Heart …

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