Barbara Katharina Geist

Stress-induced Metabolic Remodeling of Adipose and Brain Tissue revealed by Positron Emission Tomography

Maximilian Krisch, Öykü Özer, Jayne Louise Wilson, Sabine Macho‐Maschler et autres

Abstract Stress impacts our health and triggers physiological adaptations, yet the metabolic programs engaged during stress remain incompletely understood. To fill this knowledge gap, we utilized total-body positron emission tomography (PET), multi-OMICS, and endocrine profiling to assess how various murine stress models …

at (code pays fourni par la source)

Amygdala metabolic activity on [ 18 F]FDG PET is associated with survival, response to immune checkpoint inhibition, and tumor immune signaling in non-small cell lung cancer

Barbara Katharina Geist, Chrysoula Vraka, Clara T.S. Mertel, Lucian Beer et autres

Abstract Amygdala metabolic activity (AmygAc) measured by [ 18 F]FDG PET has been associated with chronic psychological stress and adverse clinical outcomes, but its relationship with antitumor immunity and treatment response remains incompletely understood. We investigated AmygAc as a host-derived imaging biomarker …

at, de, cz (code pays fourni par la source)

Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative

Daria Ferrara, Manuel Melo Pires, Sebastian Gutschmayer, Josef Yu et autres

Abstract We present a large whole-body and total-body curated dataset of dual-modality 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) studies, consisting of 1,683 PET/CT images and the corresponding CT-derived segmentations of 130 target regions. This multi-center dataset includes images from individuals …

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Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative.

Daria Ferrara, Manuel Pires, Sebastian Gutschmayer, Josef Yu et autres

F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) studies, consisting of 1,683 PET/CT images and the corresponding CT-derived segmentations of 130 target regions. This multi-center dataset includes images from individuals without overt disease and patients with a range of malignant and inflammatory pathologies, including …

at, us, it, gb, de (code pays fourni par la source)

Mechanisms of SGLT inhibitor action and physiological mediators: systematic review and protocol for the MOSAIC collaborative meta-analysis

Luxcia Kugathasan, Massimo Nardone, Marcel Muskiet, Juan Pablo Díaz Martinez et autres

INTRODUCTION: Sodium-glucose cotransporter (SGLT) inhibitors have shown substantial benefit in reducing cardiovascular and kidney events across diverse clinical populations, but the underlying physiological mechanisms remain unclear. However, existing mechanistic studies on renal and cardiovascular haemodynamics show variability in design, have limited statistical …

ca, nl, dk, us, de, no, at, jp, gr, it (code pays fourni par la source)

A Deterministic Organ-network Biomarker From Routine FDG-PET

Barbara Katharina Geist, Alexander Grentner, Raffaella Calabretta, Holger Einspieler et autres

at (code pays fourni par la source)

ENHANCE.PET 1.6k: a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations

Daria Ferrara, Manuel Pires, Sebastian Gutschmayer, Josef Yu et autres

We present a large whole-body and total-body curated dataset of PET/CT studies, consisting of 1,683 PET/CT images and the corresponding CT-derived segmentations of 130 target regions, including abdominal organs, muscles, bones, cardiac subregions, vessels, adipose tissue, and skeletal muscle around the third …

at, us, it, de (code pays fourni par la source)

Feasibility of [68Ga]Ga-FAPI PET Molecular Imaging in Atherosclerosis Compared with [18F]FDG in Oncological Patients

Raffaella Calabretta, Barbara Katharina Geist, Dina Muin, Lucia Zisser et autres

Background: Cardiovascular disease (CVD), driven primarily by atherosclerosis, is a major cause of morbidity and mortality among cancer patients. This study aims to evaluate the diagnostic value of [68Ga]Ga-FAPI-PET as a novel molecular imaging tool for atherosclerosis, compared with established, non-specific [18F]FDG. …

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Total-body [18F]FDG-PET/CT imaging of healthy volunteers with minimal effective dose

Daria Ferrara, Sebastian Gutschmayer, Zacharias Chalampalakis, Barbara Katharina Geist et autres

Abstract Purpose High-sensitivity, total-body (TB) positron emission tomography (PET) and computed tomography (CT) imaging systems enable substantial reduction of injected radioactivity without compromising image quality. Synthetic CT-like attenuation maps can be generated from PET data via deep learning (DL) to further minimise …

at (code pays fourni par la source)

Whole-Body [18F]FDG-PET/CT Imaging of Healthy Controls: Test/Retest Data for Systemic, Multi-Organ Analysis

Sebastian Gutschmayer, Josef Yu, Barbara Katharina Geist, Öykü Özer et autres

Abstract Positron Emission Tomography (PET) with 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) and Computed Tomography (CT) are key tools in oncology diagnostics. However, most PET studies focus on tumour detection. We propose that a holistic assessment of the macroenvironment using FDG-PET could enhance our …

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Early experiences of monitoring healthy controls with total-body FDG-PET/CT

Sebastian Gutschmayer, Daria Ferrara, Barbara Katharina Geist, Öykü Özer et autres

FDG-PET/CT provides essential metabolic information for oncology diagnostics and may help assess systemic health in asymptomatic individuals. Reliable baseline values from healthy subjects are needed as references for disease detection, while acknowledging public concerns about radiation exposure. In this study, we performed …

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The metabolic organ connectome: A novel approach to measure allostatic load during health-to-disease transition

Barbara Katharina Geist, Julia Guthrie, Hunor Kertész, Florian W. Kiefer et autres

BACKGROUND: F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) can quantify organ-specific glucose metabolism but is underutilized for inter-organ metabolic analysis. METHODS: We analyzed 658 whole-body FDG-PET scans to construct partial correlation networks (PCNs) reflecting direct metabolic connectivity between organs. We introduced two network metrics, …

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