Accès ouvert
2026
article
OpenAlex
Roman J. Krawetz, Mark Matyas, Saleem Abubacker, Dwaraka Natha Veeramreddy et autres
OBJECTIVES: Autoantibodies targeting extracellular matrix proteins are emerging as critical contributors to arthritis pathogenesis, yet their presence across different arthropathies remains incompletely characterized. This study investigated systemic and local expression of proteoglycan 4 (PRG4) and cartilage oligomeric matrix protein (COMP), alongside their …
ca, us
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Accès ouvert
2026
article
OpenAlex
Hao Cheng Shen, Marie Hudson, Susanna Proudman, Jenny Walker et autres
Abstract Background Autoantibodies against NOR-90 are rare and have been associated with systemic sclerosis (SSc). This study seeks to identify the characteristics of SSc participants with anti-NOR-90 autoantibodies. Methods An international (Canada, Australia, USA, Mexico) cohort of 2143 SSc participants was included. …
ca, au, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Konstantin N. Konstantinov, Nikifor K. Konstantinov, Wilson de Melo Cruvinel, Luis.E.C. Andrade et autres
The nuclear envelope (NE) is a complex intracellular structure unique to eukaryotic cells. The principal components identified by a variety of methods include the inner nuclear lamina comprised primarily of lamin proteins, the inner nuclear membrane (INM), the nuclear pore (NuP) complexes …
us, br, at, ca
(code pays fourni par la source)
Accès ouvert
2026
conference-paper
OpenAlex
Cheng Shen, Marie Hudson, Susanna Proudman, Jenny Walker et autres
Introduction Autoantibodies against NOR-90 are rare and have been associated with systemic sclerosis (SSc). This study seeks to identify the characteristics of SSc participants with anti-NOR-90 autoantibodies. Material and Methods An international (Canada, Australia, USA, Mexico) cohort of 2143 SSc participants were …
ca, au, us
(code pays fourni par la source)
Accès ouvert
2026
conference-paper
OpenAlex
Birthe Michiels, Jean‐Baptiste Vulsteke, Marie Vanthuyne, May Choi et autres
Introduction The identification of specific autoantibodies can aid in the diagnosis, prognosis and management of systemic sclerosis (SSc). Commercial solid phase assays (including line blots and dot blots) are widely used for detection of SSc-specific and SSc-associated antibodies but may suffer from …
be, nl, ca, Afrique du Sud, fr, us, si, gb
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Accès ouvert
2026
article
OpenAlex
Heinrike Schmeling, Jens Klotsche, Babatope O. Adebiyi, Frank Dressler et autres
OBJECTIVE: To identify serum biomarkers associated with the development of uveitis in a German juvenile idiopathic arthritis (JIA) cohort. METHODS: A convenience sample, enriched for uveitis cases, was drawn from a prospectively followed inception cohort of newly diagnosed JIA patients (ICON). Baseline …
ca, de, at
(code pays fourni par la source)
Accès ouvert
2026
conference-paper
OpenAlex
Sajida Alkadri, Marvin J. Fritzler, Paul Sciore, Ashley N. Clarke et autres
Lupus nephritis (LN) and renal ANCA-associated vasculitis (rAAV) are autoimmune kidney diseases that can lead to kidney failure, cardiovascular complications, and death. Kidney biopsy remains the gold-standard diagnostic, an invasive procedure with risks. Commonly used non-invasive surrogates, including urine protein-creatinine ratios (UPCR), …
ca
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Roko P.A. Nikolic, Eldad Ben‐Chetrit, Marvin J. Fritzler, Katherine A Buhler et autres
OBJECTIVES: Autoantibodies directed against Telomerase RNA Ro y-RNAs and Vault RNAs Domain Family Member 2 (TROVE2)/Ro60 and Tripartite Motif 21 (TRIM21)/Ro52 are historically related to distinct SSA/Ro autoantigens. However, despite advances facilitating separate testing, these autoantibodies remain frequently confused resulting in a …
ca, il, us, br, nl, au, at, jp
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Darya S. Jalaledin, Hajar El Kamouni, Alexandra Albert, Sabrina Hoa et autres
OBJECTIVE: The RNA-binding region-containing protein 3 (RNPC3) protein acts as a molecular bridge, promoting U11/U12 RNP complex formation. In previous reports, patients with systemic sclerosis (SSc) with anti-RNPC3 autoantibodies had an increased risk of interstitial lung disease (ILD), severe gastrointestinal (GI) disease, …
ca, jp
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Georgina R. Harvey, Idil Ashur, Xavier Bossuyt, Martin Bluethner et autres
OBJECTIVES: Myositis-specific and myositis-associated autoantibodies (MSA/MAA) are important biomarkers used in the diagnosis and assessment of patients with idiopathic inflammatory myopathies. To date, limited guidance exists on how testing should be undertaken or which MSA/MAA to include in a clinically justifiable 'myositis …
gb, be, au, us, ca, jp, fr, cz, es, se
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Accès ouvert
2026
article
OpenAlex
Nathan Barreth, Valérie Leclair, Marie Hudson, Sasha Bernatsky et autres
OBJECTIVES: To investigate soluble circulating sialic acid-binding Ig-like lectin 1 (scSIGLEC1), a surrogate biomarker for type I IFN, as a novel biomarker for idiopathic inflammatory myopathies (IIM) disease activity. METHODS: Patients enrolled in a Canadian multicentre cohort of IIM patients with biobanked …
ca
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Accès ouvert
2025
article
OpenAlex
Wolfgang Zierer, Marvin J. Fritzler, Tsan-Hung Chiu, Ravi B. Anjanappa et autres
Abstract Cassava ( Manihot esculenta ) is an important crop for food security in the tropics, particularly for smallholder farmers in sub-Saharan Africa, where yields are often severely limited by pathogen pressure, nutrient deficiency and water scarcity. We expressed a non-rectifying Arabidopsis …
de, tw, ch
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