Jonathan P. Sturgeon

Restoration of anti-bacterial innate immune cell function lags behind nutritional recovery among children convalescing from complicated severe acute malnutrition

Sandra Rukobo, Kuda Mutasa, Tracy N. Phiri, Margaret Govha et autres

Children recovering from complicated severe acute malnutrition (SAM) have a high risk of infectious mortality and morbidity, which could reflect impaired anti-microbial defence. We used blood samples from a cross-sectional cohort of children under 5 years' old admitted to hospital with SAM …

Zimbabwe, Zambie, gb (code pays fourni par la source)

LPS_LMR.dta

Jonathan P. Sturgeon

Dataset

LPS_LMR.dta

Jonathan P. Sturgeon

Dataset

Intestinal Permeability Is Associated with Mortality and Readmission in Children Hospitalized with Severe Acute Malnutrition

Jonathan P. Sturgeon, Bernard Chasekwa, Joice Tome, Cherlynn Dumbura et autres

BACKGROUND: Severe acute malnutrition (SAM) is the most critical form of undernutrition, associated with high inpatient and postdischarge mortality. It is hypothesized that malnutrition enteropathy contributes to systemic inflammation by allowing translocation of intestinal pathogen-associated molecular patterns across the damaged epithelium. OBJECTIVES: …

Zimbabwe, Zambie, gb (code pays fourni par la source)

Systemic Inflammation and Growth in Children Born to Mothers With and Without HIV in Rural Zimbabwe

Ceri Evans, Jonathan P. Sturgeon, Sandra Rukobo, Margaret Govha et autres

Background: Sixteen million children are HIV-exposed but uninfected (HEU) due to the prevention of vertical transmission. Despite avoiding HIV, children who are HEU face higher risks of infections and poorer growth and development than children HIV-unexposed (HU), though mechanisms remain unclear. We …

gb, Zimbabwe, us (code pays fourni par la source)

Restoration of anti-bacterial innate immune cell function lags behind nutritional recovery among children convalescing from complicated severe acute malnutrition

Claire D. Bourke, Sandra Rukobo, Kuda Mutasa, Tracy N. Phiri et autres

gb, Zimbabwe, Zambie (code pays fourni par la source)

Diagnostic Performance of Host-based Gene Expression Diagnostics in Children With Extrapulmonary Tuberculosis: A Systematic Review

M. Siu, Maria Selinopoulou, Susan Abarca-Salazar, Jonathan P. Sturgeon et autres

BACKGROUND: Diagnosing extrapulmonary tuberculosis (EPTB) in children is challenging due to nonspecific presentations and poor diagnostic yield from conventional microbiologic tests. Host gene expression signatures offer a non-sputum-based diagnostic alternative. This systematic review evaluates their diagnostic performance in pediatric EPTB. METHODS: We …

gb, kh, vn (code pays fourni par la source)

Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration

Jonathan P. Sturgeon, Kuda Mutasa, Mutsa Bwakura‐Dangarembizi, Beatrice Amadi et autres

BACKGROUND: Severe acute malnutrition (SAM) is the most life-threatening form of undernutrition, and children hospitalised with complications have unacceptably high mortality. Complicated SAM is a multisystem disease characterised pathophysiologically by muscle wasting, systemic inflammation, metabolic dysfunction, and malnutrition enteropathy including epithelial barrier …

Zimbabwe, Zambie, gb, ie (code pays fourni par la source)

Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial

Kanta Chandwe, Mutsa Bwakura‐Dangarembizi, Beatrice Amadi, Gertrude Tawodzera et autres

Abstract Malnutrition underlies almost half of all child deaths globally. Severe Acute Malnutrition (SAM) carries unacceptable mortality, particularly if accompanied by infection or medical complications, including enteropathy. We evaluated four interventions for malnutrition enteropathy in a multi-centre phase II multi-arm trial in …

Zambie, Zimbabwe, gb, ie (code pays fourni par la source)

Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition

Jonathan P. Sturgeon, Joice Tome, Cherlynn Dumbura, Florence D. Majo et autres

Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly when children require hospitalization for complications. Complicated SAM is a multisystem disease with high inpatient and postdischarge mortality, especially in children with comorbidities such as HIV; however, the underlying pathogenesis …

gb, Zimbabwe, Zambie (code pays fourni par la source)

Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells

Tracy N. Phiri, Kuda Mutasa, Sandra Rukobo, Margaret Govha et autres

Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) hospitalized with SAM in Zambia and Zimbabwe ( n = 141) …

Zambie, Zimbabwe, gb (code pays fourni par la source)

Risk factors for inpatient mortality among children with severe acute malnutrition in Zimbabwe and Zambia

Jonathan P. Sturgeon, Wadzanai Mufukari, Joice Tome, Cherlynn Dumbura et autres

BACKGROUND/OBJECTIVES: Malnutrition underlies 45% of deaths in children under-5 years annually. Children hospitalised with complicated severe acute malnutrition (SAM) have unacceptably high mortality. We aimed to identify variables from early hospital admission (baseline factors) independently associated with inpatient mortality in this cohort …

gb, Zimbabwe, Zambie (code pays fourni par la source)