Tracy N. Phiri

A cross‑sectional analysis of vitamin D status and associated factors in children recovering from severe acute malnutrition in Zambia and Zimbabwe

Tracy N. Phiri, Cherlynn Dumbura, Kuda Mutasa, Deophine Ngosa et autres

Mortality following severe acute malnutrition (SAM) remains high in Africa. Some children with SAM have altered immune responses and impaired neurodevelopment; however, whether vitamin D deficiency contributes to these poor outcomes remains unclear. We conducted a cross-sectional analysis of circulating 25-hydroxyvitamin D …

Zambie, gb, us, kz (code pays fourni par la source)

Circulating Immune Cell Phenotypes are Associated with Socioeconomic Status and Severity of Environmental Enteropathy Among Zambian Adults

Tracy N. Phiri, Enala Musheba, Annie E Simoonga, Limpo Muyunda et autres

Abstract Environmental enteropathy (EE) is a chronic, subclinical disorder of the small intestine common in low- and middle-income countries (LMICs), where access to sanitation and exposure to enteric pathogens vary greatly by socioeconomic status (SES). Systemic immune cell activation by enteric microbial …

Zambie, gb (code pays fourni par la source)

O16 Adults from a low socio-economic status living with environmental enteropathy have a dampened systemic T cell immune phenotype

Tracy N. Phiri, Enala Musheba, Paul Kelly, Claire D. Bourke

Introduction Environmental Enteropathy (EE) is a subclinical disorder of the small intestine in people living in tropical or insanitary environments, leading to disrupted barrier function. This disruption drives microbial translocation, chronic systemic inflammation and impaired nutrient absorption. Most research on EE in …

Zambie, gb (code pays fourni par la source)

Non-invasive measurement of intestinal barrier function in environmental enteropathy using transcutaneous fluorescence sensing

Elena Monfort Sánchez, Nilanjan Mandal, Mulima Mwiinga, Rosemary Banda et autres

Background Undernutrition represents a critical global health concern and is associated with a multifaceted breakdown in gut function—termed environmental enteropathy (EE)—which leads to increased intestinal permeability, inflammation and nutrient malabsorption. Current clinical approaches to assess intestinal permeability are costly, invasive, unreliable and/or …

gb, Zambie (code pays fourni par la source)

Restoration of anti-bacterial innate immune cell function lags behind nutritional recovery among children convalescing from complicated severe acute malnutrition

Claire D. Bourke, Sandra Rukobo, Kuda Mutasa, Tracy N. Phiri et autres

gb, Zimbabwe, Zambie (code pays fourni par la source)

Non-invasive measurement of intestinal barrier function in environmental enteropathy using transcutaneous fluorescence sensing

Elena Monfort-Sanchez, Nilanjan Mandal, Mulima Mwiinga, Rose Banda et autres

ABSTRACT Background Undernutrition represents a critical global health concern and is associated with a multifaceted breakdown in gut function – termed environmental enteropathy (EE) – which leads to increased intestinal permeability, inflammation and nutrient malabsorption. Current clinical approaches to assess intestinal permeability …

gb, Zambie (code pays fourni par la source)

Strengths and limitations of urinary sugar testing: an observational study of intestinal permeability and absorption in adults and children in Zambia and Tanzania with reference to mucosal biopsies

Ellen Besa, Beatrice Amadi, Violet Kayamba, Tracy N. Phiri et autres

Zambie, gb, us, Tanzanie (code pays fourni par la source)

An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub-Saharan Africa: Co-SAM trial protocol

Mutsa Bwakura‐Dangarembizi, Beatrice Amadi, Benson Singa, Sofia Muyemayema et autres

INTRODUCTION: Children discharged from hospital following management of complicated severe acute malnutrition (SAM) have a high risk of mortality, readmission and failed nutritional recovery. Current management approaches fail to sufficiently promote convalescence after inpatient nutritional rehabilitation. Novel interventions during the post-discharge period …

Zimbabwe, Zambie, Kenya, be, gb, us (code pays fourni par la source)

Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross-sectional study protocol

Tracy N. Phiri, James W. Weatherill, Elena Monford-Sanchez, José Iván Serrano-Contreras et autres

Background Environmental enteropathy (EE) is a highly prevalent subclinical inflammatory intestinal disorder associated with growth failure, impaired neurocognitive development, poor response to oral vaccines, and micronutrient deficiencies. However, EE research and clinical trials are hampered by the lack of non-invasive tools for …

Zambie, gb, Zimbabwe (code pays fourni par la source)

Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross-sectional study protocol

Tracy N. Phiri, James W. Weatherill, Elena Monford-Sanchez, José Iván Serrano-Contreras et autres

Background Environmental enteropathy (EE) is a highly prevalent subclinical inflammatory intestinal disorder associated with growth failure, impaired neurocognitive development, poor response to oral vaccines, and micronutrient deficiencies. However, EE research and clinical trials are hampered by the lack of non-invasive tools for …

Zambie, gb, Zimbabwe (code pays fourni par la source)

Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells

Tracy N. Phiri, Kuda Mutasa, Sandra Rukobo, Margaret Govha et autres

Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) hospitalized with SAM in Zambia and Zimbabwe ( n = 141) …

Zambie, Zimbabwe, gb (code pays fourni par la source)

Severe acute malnutrition promotes bacterial binding over pro-inflammatory cytokine secretion by circulating innate immune cells

Tracy N. Phiri, Kuda Mutasa, Sandra Rukobo, Margaret Govha et autres

ABSTRACT Children with severe acute malnutrition (SAM) are at high risk of infectious mortality and morbidity during and after hospital discharge. This risk persists despite nutritional and prophylactic antibiotic interventions among children with SAM, implicating persistent deficits in their immune defenses. Here …

Zambie, Zimbabwe, gb (code pays fourni par la source)