Accès ouvert
2026
article
OpenAlex
Zhichao Lu, Yi Shuai, Chenxing Wang, Zongheng Liu et autres
Traumatic brain injury (TBI) disproportionately affects the elderly, yet the underlying mechanisms remain unclear. Here, we demonstrate that aged TBI brains predominantly harbor proinflammatory NLRP3+ microglia, in stark contrast to the neuroprotective Lysozyme+ microglia prevalent in young TBI brains. This age-dependent microglial …
cn, hk, mo, au
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2024
article
OpenAlex
Chunye Xu, Qianqian Liu, Jinlong Shi, Zongheng Liu et autres
DNA molecules can form predictable nanostructures through sequence-directed hybridization. In this study, DNA nanospheres were designed for fluorescence/magnetic resonance imaging and drug delivery in glioma-bearing mice. DNA nanospheres were constructed using Y-shaped DNA, linker DNA, and an DNA aptamer through the hybridization …
cn
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Accès ouvert
2024
article
OpenAlex
Zhichao Lu, Zongheng Liu, Chenxing Wang, Rui Jiang et autres
INTRODUCTION: The diversity in microglial phenotypes and functions following traumatic brain injury (TBI) is poorly characterized. The aim of this study was to explore precise targets for improving the prognosis of TBI patients from a microglial perspective. OBJECTIVES: To assess whether the …
cn
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Accès ouvert
2024
article
OpenAlex
Chenxing Wang, Xingjia Zhu, Ming Zheng, Yixun Chen et autres
Prostate stem cell antigen (PSCA) is associated with disease progression, promotion of angiogenesis, invasion, metastasis and immune evasion in cancer. However, its expression pattern and diagnostic and prognostic potential have not been thoroughly analysed from a pan-cancer perspective. This study aimed to …
cn
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Accès ouvert
2023
article
OpenAlex
Fanming Kong, Xinyu Yang, Zhichao Lu, Zongheng Liu et autres
Non-small cell lung cancer (NSCLC) has long been the deadliest malignancy worldwide, with adenocarcinoma (AD) being the most common pathological subtype. Here we focused on the value of LASTR in LUAD. Using expression analysis, enrichment analysis, immune cell infraction analysis, we found …
cn, mo
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Accès ouvert
2023
article
OpenAlex
Yidan Sun, Xinyu Yang, Shiqi Ren, Zhichao Lu et autres
Prostate adenocarcinoma (PRAD) is a major threat to male health worldwide with a high mortality rate. New therapeutic strategies for the treatment of this malignant disease are of tremendous significance. Much attention has been paid to the involvement of immune cells in …
cn, mo
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Accès ouvert
2022
article
OpenAlex
Zongheng Liu, Long Peng, Yidan Sun, Zhichao Lu et autres
Background: Glioma as the most frequently discovered tumor affecting the brain shows significant morbidity and fatality rates with unfavorable prognosis. There is an urgent need to find novel therapeutic targets to overcome the low chemotherapeutic efficacy of glioma. This research examined whether …
cn
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Accès ouvert
2022
article
OpenAlex
Weichen Wang, Zhichao Lu, Maoyu Wang, Zongheng Liu et autres
Background: Copper ions are essential for cellular physiology. Cuproptosis is a novel method of copper-dependent cell death, and the cuproptosis-based signature for glioma remains less studied. Methods: Several glioma datasets with clinicopathological information were collected from TCGA, GEO and CGGA. Robust Multichip …
cn
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