Maoyu Wang

Integrated multicenter single-cell atlas of bladder cancer reveals tumor heterogeneity associated with immunotherapy

Ziwei Wang, Wei He, Maoyu Wang, Meimian Hua et autres

BACKGROUND: Molecular subtyping of bladder cancer (BCa) using bulk transcriptomic data is hindered by tumor microenvironment (TME) contamination and intra-tumoral heterogeneity. These factors also contribute to variable responses to immune checkpoint inhibitor (ICI) therapy. Single-cell RNA sequencing offers a high-resolution approach to …

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Derivation and validation of the SLNA score: a tumor size-location-number-apperance model to predict transurethral resection of bladder tumor (TURBT) complexity

Hui Zhang, Chen Zhang, Jinshan Xu, Maoyu Wang et autres

Background: Transurethral resection of bladder tumor (TURBT) is the core surgical procedure for the diagnosis and treatment of bladder cancer, with significant variations in its surgical complexity that directly affect the difficulty of surgical operation, the risk of perioperative complications, and the …

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Efficacy and safety of tislelizumab plus intravesical chemotherapy in recurrent high-risk non-muscle-invasive bladder cancer: A retrospective single-center real-world study

Xufeng Yu, Rongjie Wu, Chen Zhang, Jiaxin Xie et autres

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Epidemiological transition of breast and urogenital tumors in children and adolescents from the perspective of the Global Burden of Disease

Wei He, Yuchen Li, Qing Chen, Ziwei Wang et autres

BACKGROUND: Breast and urogenital tumors are relatively rare in children and adolescents, with sparse and fragmented data on their global disease burden, lacking comprehensive epidemiological assessment. METHODS: Using Global Burden of Disease (GBD) 2021 data, we analyzed incidence, mortality, prevalence, and disability-adjusted …

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Single-cell and spatial atlas unveil tumor-specific microenvironment convergence and a prognosis-associated PLXDC1+ myofibroblast population in metastatic bladder cancer

Ziwei Wang, Jiaying Miao, Maoyu Wang, Yidie Ying et autres

BACKGROUND: While single-cell technologies have advanced bladder cancer research, the microenvironment of lymph node metastases and its role in progression remain unclear. We aimed to elucidate dynamic tumor-microenvironment interactions across metastatic and primary sites, identify poor-prognosis features, and uncover novel therapeutic targets. …

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Prognostic significance of lymph node yield in pelvic lymph node dissection for bladder cancer: population-based study

Wei He, Ziwei Wang, Maoyu Wang, Qing Chen et autres

BACKGROUND: Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) and pelvic lymph node dissection (PLND) is standard for muscle-invasive bladder cancer (MIBC). While PLND improves staging and local control, the optimal extent is debated. This study used the SEER database (2000–2021) to evaluate …

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Integrate Semantic Radiomics as Prior Evidence Into Evidential Deep Learning for Pelvic Lipomatosis Diagnosis

Xiaodong Yue, Maoyu Wang, Zhikang Xu, Yufei Chen et autres

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Pedunculoside regulates tumor immune microenvironment and malignant characteristics of bladder cancer by TRAF6 mediated M2 macrophage polarization

Jinshan Xu, Guandan Wang, Maoyu Wang, Xi Xu et autres

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Re: Thomas Dreyer, Simone Brandt, Fabrin Knud, et al. Use of the Xpert Bladder Cancer Monitor for Guiding Cystoscopy in High-grade Non–muscle-invasive Bladder Cancer: Results from the Randomized Controlled DaBlaCa-15 Trial. Eur Urol 2025;88:23–30

Wei He, Maoyu Wang, Chen Zhang, Shuxiong Zeng et autres

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Exploring bladder cancer through urinary microbiota: innovative “urinetypes” classification and establishment of a diagnostic model

Jing Liu, Maoyu Wang, Xiang Chen, Jinshan Xu et autres

BACKGROUND: Bladder cancer (BCa) is a prevalent and lethal malignancy of the urinary system. Recent evidence suggests a strong association between the urinary microbiota and the pathogenesis, progression, and prognosis of BCa. This study investigated the role of the urinary microbiota in …

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Neoadjuvant treatment patterns and biomarker selection in muscle-invasive bladder cancer

Wei He, Jiaxin Xie, Ziwei Wang, Maoyu Wang et autres

As the feasibility of risk-adaptive bladder-sparing treatment is increasingly validated, the prospects for neoadjuvant therapy in muscle-invasive bladder cancer (MIBC) are rapidly evolving. For patients seeking effective and tolerable treatment options, platinum-based chemotherapy, particularly dose-dense MVAC (ddMVAC), remains the preferred standard. However, …

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The role of urinary microbiota in primary and recurrent bladder cancer: insights from a propensity score matching study

Jinshan Xu, Maoyu Wang, Xi Jin Xu, Jin-Peng Zhu et autres

BACKGROUND: Bladder cancer (BCa) is a common urinary malignancy with high recurrence rates in non-muscle invasive bladder cancer (NMIBC), posing significant clinical challenges. Emerging evidence links urinary microbiota to cancer progression; however, their role in BCa recurrence remains unclear. This study aimed …

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