Xinran Xi

Copper arsenite-loaded hydrogel for breast cancer therapy via cuproptosis-induced immunity synergized with arsenic chemotherapy

Lan Yang, Faisal Raza, Jinpu Song, Xinran Xi et autres

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KLK6 regulates ferroptosis through YAP/TAZ in lung adenocarcinoma

Junyu Xu, Xinran Xi, Xun Wu, Zhongbo Yu et autres

Background: The incidence of lung adenocarcinoma (LUAD) has increased in recent years. Kallikrein related peptidase 6 (KLK6), a member of the serine protease family, is found to be aberrantly overexpressed in various solid tumors. This gene functions as a driver of tumor …

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WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Tao Huang, Qi You, Xuguang Shen, Dengjun Huang et autres

Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant cancer with high incidence and mortality rate. Many studies have shown that long noncoding RNAs (lncRNAs are involved in the progression of various types of tumors. The lncRNA protein disulfide isomerase …

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Nanocatalytic system releases overloaded zinc ions and ROS to induce Znproptosis and interrupt cell cycle through inhibiting Akt/mTOR pathway

Zhijun Xi, C. Fan, Yingying Jiang, Xinran Xi et autres

Hence, the research reveals a detailed Znproptosis mechanism in nanocatalytic system. Through regulating FDX2/LIAS pathway, Znproptosis could improve the death rate of mitochondria by decreasing the production of Fe-S protein, contributing to advancements in the field of antitumor therapy.

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Facile GSH responsive glycyrrhetinic acid conjunction for liver targeting therapy

Xinran Xi, Xiyu Wang, Ziyue Xi, Chuanyong Fan et autres

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Nanomaterials evoke pyroptosis boosting cancer immunotherapy

Zhenhua Li, Ziyue Xi, Chuanyong Fan, Xinran Xi et autres

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness is restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, a unique form of programmed cell death (PCD), causes cells to swell and rupture, releasing …

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NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer

Chengwei Wu, Song Wang, Tao Huang, Xinran Xi et autres

Cisplatin-based chemotherapy serves as the standard of care for individuals with advanced stages of gastric cancer. Nevertheless, the emergence of chemoresistance in GC has detrimental impacts on prognosis, yet the underlying mechanisms governing this phenomenon remain elusive. Level of mitophagy and ferroptosis …

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PAFerroptosis Combined with Metabolic Disturbance of Mito by p52‐ZER6 for Enhanced Cancer Immunotherapy induced by Nano‐Bacilliform‐Enzyme

Ziyue Xi, Chuanyong Fan, Shuang Zhu, Gan‐yu Nie et autres

The confused gene expressions and molecular mechanisms for mitochondrial dysfunction of traditional nanoenzymes is a challenge for tumor therapy. Herein, a nano-bacilliform-enzyme obtains the ability to inhibit p52-ZER6 signal pathway, regulate the genes related to mitochondrial metabolism, and possess the GOx/CAT/POD-like property. …

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Identification of PRODH as a mitochondria- and angiogenesis-related biomarker for lung adenocarcinoma

Xinran Xi, Meng Zhang, Yonghua Li

Background: as a mitochondrial gene in LUAD. Methods: This study identified genes related to mitochondria and angiogenesis in LUAD. Based on the high and low expression of the genes in LUAD, we grouped them and conducted relevant bioinformatics analysis on the differentially …

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Using Mesoporous Silica-Based Dual Biomimetic Nano-Erythrocytes for an Improved Antitumor Effect

Ziyue Xi, Yingying Jiang, Zitong Ma, Qun Li et autres

The nano-delivery system with a dual biomimetic effect can penetrate deeper in tumor microenvironments (TMEs) and release sufficient antitumor drugs, which has attracted much attention. In this study, we synthesized erythrocyte-like mesoporous silica nanoparticles (EMSNs) as the core loaded with doxorubicin (DOX) …

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Identification of PRODH as a mitochondria and angiogenesis related biomarker for the lung adenocarcinoma

Xinran Xi, Meng Zhang, Y Li, Xianghai Wang

Abstract Background: The mitochondria and their associated genes were highly related to cellular metabolism. It plays a vital role in the therapy tumors. Angiogenesis is a critical process in the development and progression of tumors, including lung adenocarcinoma. Tumor growth and metastasis …

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Synthesis and Characterization of a Series of Temozolomide Esters and Its Anti-glioma Study

Yawen Yu, Liangxiao Wang, Junping Han, Aiping Wang et autres

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