Alessandro Mancini

Volumetric Absorptive Microsampling (VAMS) for Therapeutic Drug Monitoring of Antiseizure Medications (ASMs) in Pediatric Patients

Raffaele Simeoli, Alessandro Mancini, Sara Cairoli, Christopher Rossi et autres

Background: Volumetric absorptive microsampling (VAMS) is an emerging tool for therapeutic drug monitoring (TDM) of several drugs including antiseizure medications (ASMs). Here, we compared the concentrations of carbamazepine (CBZ), levetiracetam (LEV), lacosamide (LCS), topiramate (TPR) and the benzodiazepine (BZ) clobazam (CLB) in …

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Prenatal Elexacaftor/Tezacaftor/Ivacaftor for Fetal Meconium Ileus: First Italian Case and Narrative Overview of the Emerging Evidence

Alessandra Boni, Chiara Vassallo, Fabiana Ciciriello, Luca Cristiani et autres

Introduction: Cystic fibrosis (CF) frequently presents prenatally with meconium ileus (MI), a condition associated with significant neonatal morbidity and long-term gastrointestinal complications. The advent of highly effective CFTR modulators, particularly elexacaftor/tezacaftor/ivacaftor (ETI), during pregnancy remains off-label, and their role as in utero …

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Prenatal Elexacaftor/Tezacaftor/Ivacaftor for Fetal Meconium Ileus: First Italian Case and Narrative Review of the Emerging Evidence

Alessandra Boni, Chiara Vassallo, Fabiana Ciciriello, Luca Cristiani et autres

Introduction: Cystic fibrosis (CF) frequently presents prenatally with meconium ileus (MI), a condition associated with significant neonatal morbidity and long-term gastro-intestinal complications. The advent of highly effective CFTR modulators, particularly elexacaftor/tezacaftor/ivacaftor (ETI), during pregnancy remains off-label, and their role as in-utero therapy …

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Development and Validation of a New LC-MS/MS Method for Simultaneous Quantification of Ivacaftor, Tezacaftor and Elexacaftor Plasma Levels in Pediatric Cystic Fibrosis Patients

Alessandro Mancini, Raffaele Simeoli, Luca Cristiani, Sara Cairoli et autres

Background: “CFTR modulators” (also named “caftor”) have been developed and introduced into clinical practice to improve the functionality of defective CFTR protein. Therapeutic drug monitoring (TDM) is not currently used for CFTR modulators in routine clinical practice and there is still much …

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Measurement of Anti-TNF Biologics in Serum Samples of Pediatric Patients: Comparison of Enzyme-Linked Immunosorbent Assay (ELISA) with a Rapid and Automated Fluorescence-Based Lateral Flow Immunoassay

Chiara Rossi, Raffaele Simeoli, Giulia Angelino, Sara Cairoli et autres

Background: Therapeutic drug monitoring (TDM) of infliximab (IFX) and adalimumab (ADL) mainly relies on the use of enzyme-linked immunosorbent assays (ELISA). More recently, rapid assays have been developed and validated to reduce turnaround time (TAT). Here, we compared IFX and ADL concentrations …

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A New and Rapid LC-MS/MS Method for the Determination of Cysteamine Plasma Levels in Cystinosis Patients

Raffaele Simeoli, Sara Cairoli, Marcella Greco, Francesco Bellomo et autres

gene that encodes for the cystine transporter cystinosin, which is expressed on the lysosomal membrane mediating the efflux of cystine. Cysteamine bitartrate is a cystine-depleting aminothiol agent approved for the treatment of cystinosis in children and adults. In this study, we developed …

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Efficacy And Safety Of Full Thickness Resection (FTR) For Colonic Lesions In A Tertiary Care Center

Andrea Magarotto, Federica Cavalcoli, Alessandro Mancini, Enzo MASCI

Aims Aim of this study is to determine the effectiveness and safety of FTR of colic lesions not amenable to resection with traditional techniques or for treating lesions bigger than 2 cm or with a combined endoscopic treatment (EMR and FTR) or …

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63. Guillain-Barrè syndrome with marked pleocytosis in the cerebrospinal fluid: A case report

Giuseppe Stipa, Sandro Carletti, Domenico Frondizi, C. Fanelli et autres

33. A rare case of Guillain–Barre’ syndrome and pseudotumor cerebri, with normal cerebrospinal fluid protein

Giuseppe Stipa, Stefano Caproni, Elisa Moschini, A. Sensidoni et autres

The integration of vascular surgical techniques with oncological surgical protocols in the treatment of soft tissue sarcomas of the limbs.

Ugo Bertoldo, Brach del Prever Em, G Gino, Danilo Mellano et autres

Soft tissue tumors, involving the vascular bundle, require a particular surgical approach: oncological and vascular surgical techniques must be integrated in order to perform a limb-saving surgery with adequate margins. Thirty-six soft tissue sarcomas of the thigh and popliteal region were treated …

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Localized unresectable neuroblastoma: results of treatment based on clinical prognostic factors

Alberto Garaventa, Luca Boni, M. S. Lo Piccolo, Giuseppe Tonini et autres

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Limits of aortic stop flow infusion chemotherapy in the treatment of advanced cancer.

Claudio Zanon, M Goss, Fazio Nicola, Oscar Alabiso et autres

BACKGROUND: Advanced and relapsed tumors remain a challenging disease with a poor and dismal prognosis. Our choice for inoperable tumors consists in a percutaneous treatment strategy involving intra-arterial chemotherapy and hemofiltration, with previous blood stop-flow, which allows high doses of Cisplatin-cisplatinum, cis-diammine-dichloroplatinum …

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