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M Mueller, Nicholas T. Southern, Dominik Niopek
Abstract Adenine base editors (ABEs) enable efficient A•T to G•C conversion, but their broad activity windows frequently cause unintended bystander edits. We hypothesized that insertion of a bulky, inert protein domain into the base editor would limit the effective reach of the …
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Nicholas T. Southern, Adrian Bachmann, Alisa Hovsepyan, Marielouise Griebl et autres
Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation. Artificial allosteric effectors enable remote manipulation of cell function; their engineering, however, is hampered by our limited understanding of allosteric residue networks. Here, …
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Ann-Sophie Kroell, Kira H Hoffmann, Nikolas Alexander Motzkus, Nina Lemmen et autres
Thermogenetics enables noninvasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membrane recruitment. Here, we present a generalizable strategy for engineering thermosensitive allosteric proteins through the insertion of optimized …
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Nicholas Southern, Anna von Bachmann, Alisa Hovsepyan, Marielouise Griebl et autres
No description provided.
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Nicholas Southern, Anna von Bachmann, Alisa Hovsepyan, Marielouise Griebl et autres
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Benedict Wolf, Jan Mathony, Dominik Niopek
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Petra E. M. Balbi, Ahmed K. Sadek, Anthony Marchand, Ta-Yi Yu et autres
The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo protein binder design against these cell surface proteins offers a promising yet underexplored strategy for drug development. However, the vast search space …
Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek
The 3D organization of the genome constitutes a spatial layer of information processing that helps govern gene expression and thus cell function. Advances in chromosome conformation capture sequencing have enabled detailed assessment of chromatin architecture, from enhancer-promoter loops to topological domains and …
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Benedict Wolf, Pegi Shehu, Luca Brenker, Ann-Sophie Kroell et autres
Domain insertion engineering is a powerful approach to juxtapose otherwise separate biological functions, resulting in proteins with new-to-nature activities. A prominent example are switchable protein variants, created by receptor domain insertion into effector proteins. Identifying suitable, allosteric sites for domain insertion, however, …
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Luca Brenker, Sabine Aschenbrenner, Felix Bubeck, Kaloyan Staykov et autres
CRISPR-Cas technologies have revolutionized life sciences by enabling programmable genome editing across diverse organisms. Achieving dynamic and precise control over CRISPR-Cas activity with exogenous triggers, such as light or chemical ligands, remains an important need. Existing tools for CRISPR-Cas control are often …
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Jeffrey C. Way, Daniel Heid, Maria Theiss, Simon Flyvbjerg Nørrelykke et autres
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Ann-Sophie Kroell, Nikolas Alexander Motzkus, Nina Lemmen, Nele Happ et autres
Abstract Thermogenetics enables non-invasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membrane recruitment. Here, we present a generalizable strategy for engineering thermosensitive allosteric proteins through the insertion of …
de (code pays fourni par la source)
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