Jian‐Chuan Xia

CPNE1 promotes stemness and confers resistance to GPC3 CAR-T cell therapy in hepatocellular carcinoma via the STAT3–TGF-β signaling pathway

Hao Zhang, Tong Xiang, 潘秋中, Mengjia Song et autres

BACKGROUND: Hepatocellular carcinoma (HCC) remains a major global health burden with limited effective therapeutic strategies. Although chimeric antigen receptor (CAR) T-cell therapy has shown encouraging potential, its efficacy in HCC is profoundly constrained by the immunosuppressive tumor microenvironment. METHODS: In this study, …

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Annexin A3 potentiates lenvatinib resistance in hepatocellular carcinoma through multiple approaches amplified by a positive feedback loop

Yingqin Zhu, Yue Huang, Mengjia Song, Jieying Yang et autres

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies with limited treatment options. Lenvatinib is a first-line drug for advanced HCC. However, its effect on patient survival is limited and patients ultimately develop disease progression due to drug resistance. In this …

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Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway

Haohuan Li, Qian Yu, Xianlong Zhou, Haoli Ma et autres

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Intraoperative blood perfusion factors in free anterolateral thigh flap repair for diabetic foot ulcers: A retrospective analysis

Hongliang Wu, Huan Huang, B.Y. Chen, Jian‐Chuan Xia et autres

BACKGROUND Diabetic foot ulcers (DFUs) in patients with type 2 diabetes (T2D) are associated with heightened risks of infection and amputation and thus require effective surgical interventions to enhance outcomes. Free anterolateral thigh (ALT) perforator flap is a promising reconstructive method; however, …

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MiqroForge: An Intelligent Workflow Platform for Quantum-Enhanced Computational Chemistry

Jianan Wang, Wenbo Guo, Xin Yue, Xu Minjie et autres

The connect-fill-run workflow paradigm, widely adopted in mature software engineering, accelerates collaborative development. However, computational chemistry, computational materials science, and computational biology face persistent demands for multi-scale simulations constrained by simplistic platform designs. We present MiqroForge, an intelligent cross-scale platform integrating quantum …

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song et autres

Although Epstein-Barr virus (EBV)-associated epithelial cancers are categorized as immunologically "hot" tumors, they have unsatisfactory responses to immunotherapy. Increasing evidence has shown that therapeutic failure is due to an immunosuppressive tumor microenvironment established by EBV. In this study, a negative correlation is …

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Current practices and knowledge of adenosine administration for paroxysmal supraventricular tachycardia: a multi-province survey in Chinese emergency departments

Hao Zou, Guanguan Luo, Cheng Jiang, Xiaopeng Tu et autres

BACKGROUND: Paroxysmal supraventricular tachycardia (PSVT) is a common arrhythmia in emergency departments, with adenosine recommended as the first-line therapy in international guidelines. However, its adoption remains limited in China due to accessibility challenges, cost concerns, and entrenched reliance on traditional antiarrhythmics. AIM: …

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Optimization of moisture content and duration in low-speed rotational thermostatic tempering for enhanced physicochemical properties of indica rice flour

Rong Dong, Xiwu Jia, Wenjing Huang, Jian‐Chuan Xia et autres

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Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma

Jinqi You, Xinyi Yang, Jingjing Zhao, Hao Chen et autres

metformin treatment is an effective strategy to improve the efficacy of CAR-T cell therapy, potentially benefiting some relapsed HCC patients.

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Current Practices and Knowledge of Adenosine Administration for Paroxysmal Supraventricular Tachycardia: A Multi-Province Survey in Chinese Emergency Departments

Hao Zou, Guanguan Luo, Cheng Jiang, Xiaopeng Tu et autres

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Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma

Yan Wang, Yuanyuan Chen, Yuanyuan Liu, Jingjing Zhao et autres

Aberrant vascular systems are significant indicators of cancer and play pivotal roles in tumor immunomodulation. However, the role of PD-L1 expressed on vascular endothelial cells (VECs) in the tumor immune microenvironment of nasopharyngeal carcinoma (NPC), as well as its correlation with patient …

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Use of neuromuscular blocking agent for rapid sequence intubation in China: a large survey in the Hubei province

Guanguan Luo, Hao Zou, Xianlong Zhou, Jian‐Chuan Xia et autres

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