Coralie Berthoux

GluN2D-containing NMDA receptors support dentate granule cell excitability, synaptic plasticity, and memory

Coralie Berthoux, Alma Rodenas-Ruano, Laxman Bist, Kaoutsar Nasrallah et autres

N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) are crucial for synaptic transmission, long-term plasticity, neuronal activity, and cognition. Consistent with these functions, NMDAR dysfunction is linked to several brain disorders, including Alzheimer's disease, autism, schizophrenia, and depression. NMDARs are tetrameric complexes composed of two …

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Protocol to study adenosine release in the adult mouse hippocampus using a genetically encoded sensor, 2-photon live imaging, and fiber photometry

Coralie Berthoux, Pablo E. Castillo, Kaoutsar Nasrallah

Genetically encoded fluorescent sensors are powerful tools for tracking real-time neuromodulator dynamics. Here, we present a protocol to measure adenosine release using the G protein-coupled receptor activation-based adenosine (GRAB Ado1.0m ) sensor in the mouse hippocampus. We describe steps for stereotaxic surgery, …

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Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures

Kaoutsar Nasrallah, Coralie Berthoux, Yuki Hashimotodani, Andrés E. Chávez et autres

Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity. While long-term changes in neurotransmitter release commonly rely on retrograde signaling, the mechanisms remain poorly understood. Here, we identified adenosine/A 2A …

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Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior

Joongkyu Park, Coralie Berthoux, Erika Hoyos, Lili Shan et autres

Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, is believed to underlie memory formation. Hebbian, postsynaptically expressed LTP requires TARPγ-8 phosphorylation for synaptic insertion of AMPA receptors (AMPARs). However, it is unknown whether TARP-mediated AMPAR insertion alone is sufficient to modify …

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Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

Irene B. Maroto, Carlos Costas‐Insua, Coralie Berthoux, Estefanía Moreno et autres

Abstract The type-1 cannabinoid receptor (CB 1 R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB 1 R with various intracellular proteins is …

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CONTROL OF A HIPPOCAMPAL RECURRENT EXCITATORY CIRCUIT BY CANNABINOID RECEPTOR-INTERACTING PROTEIN GAP43

Irene B. Maroto, Carlos Costas‐Insua, Coralie Berthoux, Estefanía Moreno et autres

Source Data file

Control of a Hippocampal Recurrent Excitatory Circuit by Cannabinoid Receptor-interacting Protein Gap43

Irene B. Maroto, Carlos Costas‐Insua, Coralie Berthoux, Estefanía Moreno et autres

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Erratum To: Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Coralie Berthoux, Al Mahdy Hamieh, Angelina Rogliardo, E. Doucet et autres

Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized.In line with previous findings that revealed a role of 5-HT 6 receptor-operated mTOR …

BDNF induces its own release to mediate presynaptic plasticity

Coralie Berthoux, Kaoutsar Nasrallah, Teresa A. Milner, Pablo E. Castillo

Abstract The brain-derived neurotrophic factor (BDNF) and its effector Tropomyosin receptor kinase B (TrkB) mediate diverse forms of activity-dependent synaptic plasticity implicated in learning, neural circuit refinement, and brain diseases, including epilepsy and mood disorders. Here, we report that activity-dependent release of …

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Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

Taisuke Miyazaki, Megumi Morimoto‐Tomita, Coralie Berthoux, Kotaro Konno et autres

Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize neurotransmitter receptors at postsynapses. However, it remains unknown which mechanism is crucial to …

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Retrograde adenosine/A 2A receptor signaling facilitates excitatory synaptic transmission and seizures

Kaoutsar Nasrallah, Coralie Berthoux, Yuki Hashimotodani, Andrés E. Chávez et autres

Summary Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity. While long-term changes in neurotransmitter release commonly rely on retrograde signaling, the mechanisms remain poorly understood. Here, we identified adenosine/A …

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Author response: Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

Taisuke Miyazaki, Megumi Morimoto‐Tomita, Coralie Berthoux, Kotaro Konno et autres

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