Enrico D’Ambrosio

Magnetoencephalographic Microstates Reveal Disrupted Brain Activity Patterns in Schizophrenia Controlling for Treatment-Related Modulations

Angelantonio Tavella, Christian Valt, Cristina Berchio, Giuseppe Stolfa et autres

BACKGROUND AND HYPOTHESIS: Electroencephalographic (EEG) or magnetoencephalographic (MEG) microstates, ie, discrete spatial configurations of brain signals over time, are thought to reflect the activity of large-scale brain circuits. Altered EEG microstates associated with cognitive control and attention have been consistently reported in …

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Replicated evidence for an accelerated rate of whole-body aging in schizophrenia

Ethan T. Whitman, Roberta Passiatore, Annchen R. Knodt, Giulio Pergola et autres

BACKGROUND: People with schizophrenia develop more chronic diseases at a younger age and die younger than people in the general population. It has been hypothesized that this excess morbidity and mortality could be partially due to accelerated aging in schizophrenia. If true, …

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Cell models to probe the biological bases of antipsychotic-induced metabolic Syndrome: towards an individual specific approach

M. Fiore, Silvia Saltarelli, Laura De Mastro, Enrico D’Ambrosio et autres

BACKGROUND: Individuals with major psychiatric disorders are at an increased risk of developing Metabolic Syndrome (MetS), partly attributed to the dysmetabolic side effects of Second-Generation Antipsychotics (SGAs). In vitro cell models of peripheral tissues provide a valid platform to investigate the biochemical …

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One-year efficacy of the LIFESTYLE intervention in improving diet, physical activity and reducing alcohol use in overweight people with severe mental illness: multicentre randomised controlled trial

Mario Luciano, Pierluigi Catapano, Gaia Sampogna, Bianca Della Rocca et autres

Background Unhealthy eating patterns, physical inactivity and alcohol misuse are commonly reported by individuals with severe mental illness (SMI) and significantly contribute to premature mortality. People with SMI could benefit from psychoeducational interventions focused on lifestyle modification. Aims To evaluate the effectiveness …

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The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis

Toby Pillinger, Atheeshaan Arumuham, Robert Ali McCutcheon, Enrico D’Ambrosio et autres

BACKGROUND: Antidepressants induce physiological alterations; however, the degree to which these occur in treatment with various antidepressants is unclear. We aimed to compare and rank antidepressants based on physiological side-effects by synthesising data from randomised controlled trials (RCTs). METHODS: We searched MEDLINE, …

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Holistic prevention and management of physical health side-effects of psychotropic medication: second report of the Lancet Psychiatry Physical Health Commission

Sean Halstead, Chloe X. Yap, Nicola Warren, Sri Mahavir Agarwal et autres

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Correction: Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging

Alessio Giacomel, Daniel Martins, Giovanna Nordio, Rubaida Easmin et autres

In this article, the order in which the authors appeared in the author list was incorrectly given as Ilinca Angelescu 9 , Micheal Bloomfield 10 , Ilaria Bonoldi 9 , Faith Borgan 9 , Tarik Dahoun 11 , Enrico D’Ambrosio 9,12 , …

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Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging

Alessio Giacomel, Daniel Martins, Giovanna Nordio, Rubaida Easmin et autres

Abstract Molecular neuroimaging techniques, like PET and SPECT, offer invaluable insights into the brain’s in-vivo biology and its dysfunction in neuropsychiatric patients. However, the transition of molecular neuroimaging into diagnostics and precision medicine has been limited to a few clinical applications, hindered …

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Experimental pasta as an innovative approach to cholesterol reduction in patients with metabolic syndrome, with and without major psychiatric disorders: A randomized controlled trial supported by in vitro validation

Enrico D’Ambrosio, Maria Favia, Marcello Greco Miani, Francesco Pappagallo et autres

Abstract Background Elevated non-high-density lipoprotein cholesterol (non-HDL-C) is a significant risk factor for atherosclerotic cardiovascular diseases, particularly in individuals with metabolic syndrome (MetS) and major psychiatric disorders (MPDs), who may experience metabolic side effects of psychopharmacological treatments. We evaluated the cholesterol-lowering effects …

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Improving the physical health of overweight/obese people suffering from severe mental disorders: What is the role of antipsychotic drugs and of lifestyle psychosocial interventions?

Gaia Sampogna, Matteo Di Vincenzo, Mario Luciano, Bianca Della Rocca et autres

People with severe mental disorders experience premature mortality compared with the general population. Several factors contribute to the mortality gap, including the adoption of unhealthy lifestyle behaviours, poor screening for physical illnesses, difficulties in accessing healthcare facilities, specific clinical features of mental …

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Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis

Maria Rogdaki, Robert Ali McCutcheon, Enrico D’Ambrosio, Valentina Mancini et autres

BACKGROUND: The degree of physiological responses to individual antipsychotic drugs is unclear in children and adolescents. With network meta-analysis, we aimed to investigate the effects of various antipsychotic medications on physiological variables in children and adolescents with neuropsychiatric and neurodevelopmental conditions. METHODS: …

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Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo

Leonardo Sportelli, Daniel Paul Eisenberg, Roberta Passiatore, Enrico D’Ambrosio et autres

The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and …

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