Katie Clepp

Evaluation of a Direct-from-Blood Molecular Diagnostic Platform for Pathogen Detection in Critically Ill Patients: A Prospective Observational Cohort Study

Yupeng Liu, Helen Donnelly, Alvaro Donayre, Erin Korth et autres

Rationale: Defining the microbial etiology of sepsis is difficult but has important implications for antibiotic stewardship and prognosis. We explore the diagnostic yield of a novel, direct-from-blood multiplex polymerase chain reaction in intensive care unit patients with suspected sepsis. Methods: From March …

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Pathogen-specific host responses define distinct pneumonia endotypes in the human lung

Nikolay S. Markov, Marcin Możejko, Vijeeth Guggilla, Małgorzata Łazęcka et autres

Pneumonia is the leading cause of death from infectious disease worldwide. The diagnosis and treatment of patients with pneumonia lag behind other major conditions, relying on syndromic definitions that lack molecular resolution and ignore underlying endotypes. We sought to test the hypothesis …

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Transitions in lung microbiota landscape associate with distinct patterns of pneumonia progression

Jack T. Sumner, Stefanie Huttelmaier, Chiagozie I. Pickens, Anahid A. Moghadam et autres

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Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia

Vijeeth Guggilla, Chiagozie I. Pickens, Helen K. Donnelly, Anna Pawlowski et autres

Abstract Background Despite sophisticated standard of care (SOC) testing (including bronchoalveolar lavage (BAL) fluid culture and multiplex PCR), the etiology of pneumonia in immunocompromised patients is frequently unknown. Microbial cell-free DNA (mcfDNA) sequencing increases diagnostic yield in plasma but remains understudied in …

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BAL FLUID CELL-FREE MICROBIAL DNA SEQUENCING IMPROVES DIAGNOSTIC YIELD IN IMMUNOCOMPROMISED PNEUMONIA

Vijeeth Guggilla, Chiagozie I. Pickens, C.A. Gao, Helen K. Donnelly et autres

Understanding Diagnostic Uncertainty: Comparing Pre-Test Probability of Pneumonia to Bronchoalveolar Lavage Results in Critically Ill Patients

Catherine A. Gao, Helen K. Donnelly, Erin Korth, Francisco Martínez‐Martínez et autres

Rationale: While clinical criteria are used to diagnose and treat pneumonia in critically ill patients, rates of concordance between a clinicians suspicion for pneumonia and a confirmed diagnosis using bronchoalveolar lavage (BAL) results are undefined. Factors that contribute to diagnostic concordance, and …

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Comparison of a Direct-from-Blood Multiplex PCR to Blood Cultures in Critically Ill Patients: A Prospective Observational Cohort Study

Ying Liu, Chiagozie I. Pickens, Erin Korth, Bridget A. Giblin et autres

Abstract RATIONALE: Defining the microbial etiology of sepsis is difficult but has important implications for antibiotic stewardship and prognosis. In particular, the diagnostic yield of blood cultures is limited. We explore the diagnostic yield of a novel, direct-from-blood multiplex PCR in ICU …

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Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Nikolay S. Markov, Ziyou Ren, Karolina J. Senkow, Rogan A. Grant et autres

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Outcomes of a Multisite Mentored Implementation Approach to Promoting Goals of Care Conversations

Gordoń Wood, Katie Clepp, Jungwha Lee, Martha Twaddle et autres

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An Adjudication Protocol for Severe Pneumonia

Chiagozie I. Pickens, Catherine A. Gao, Justin Bodner, James M. Walter et autres

Background: Clinical end points that constitute successful treatment in severe pneumonia are difficult to ascertain and vulnerable to bias. The utility of a protocolized adjudication procedure to determine meaningful end points in severe pneumonia has not been well described. Methods: This was …

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The PACT Project: Feasibility of a Multidisciplinary, Multi-Faceted Intervention to Promote Goals of Care Conversations

Eytan Szmuilowicz, Katie Clepp, Jayson Neagle, Adeboye Ogunseitan et autres

BACKGROUND: Patients living with serious illness generally want their physicians to facilitate Goals of Care conversations (GoCc), yet physicians may lack time and skills to engage in these conversations in the outpatient setting. The problem may be addressed by supporting multiple members …

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An Adjudication Protocol for Severe Bacterial and Viral Pneumonia

Chiagozie I. Pickens, Catherine A. Gao, James M. Walter, Jacqueline M. Kruser et autres

Abstract Rationale Clinical endpoints that constitute successful treatment in severe pneumonia are difficult to ascertain and vulnerable to bias. Utility of a protocolized adjudication procedure to determine meaningful endpoints in severe pneumonia is not well described. Objectives To develop and validate a …

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