Naoki Tamasawa

Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes

Takayoshi Sasako, Kohjiro Ueki, Kengo Miyoshi, Kana Miyake et autres

Importance: Prevention of diabetic retinopathy is important to keep vision and quality of life. Objective: To examine the effects of an intensive multifactorial intervention and hypoglycemia on retinopathy in people with type 2 diabetes. Design, Setting, and Participants: J-DOIT3 (Japan Diabetes Optimal …

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Possible Insulinotropic Action of Apolipoprotein A–I Through the ABCA1/Cdc42/cAMP/PKA Pathway in MIN6 Cells

Koki Matsumura, Naoki Tamasawa, Makoto Daimon

Aims/Introduction: We studied the mechanisms for the possible insulinotropic action of apolipoprotein (Apo) A-I in mouse insulinoma (MIN6) cells. Materials and Methods: The effects of ApoA-I on cAMP production and glucose-stimulated insulin secretion (GSIS), and the dose dependency (ApoA-I at 5, 10, …

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Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Masayuki Kato et autres

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The Evaluation of Adrenal Function in Two Cases of Hypocortisolism Accompanied by Liver Cirrhosis

Maki Yamashita, Kazunori Kageyama, Hiroshi Murakami, Aya Sugiyama et autres

Adrenal insufficiency may occur in patients with liver cirrhosis. The assessment of hypothalamus-pituitary-adrenal function is important in such patients, but there is no consensus as to how it should be performed. We herein report the results of our evaluation of the adrenal …

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Clinical Significance of Determining Plasma MicroRNA33b in Type 2 Diabetic Patients with Dyslipidemia

Yuki Kimura, Naoki Tamasawa, Koki Matsumura, Hiroshi Murakami et autres

AIM: Sterol regulatory element-binding protein (SREBP)-1c is the dominant liver insulin-stimulated isoform and strongly correlates with diabetic dyslipidemia characterized by hyperinsulinemia [i.e., high-density lipoprotein cholesterol (HDL-C) levels and hypertriglyceridemia]. MicroRNA (miRNA) 33b is harbored in the intron of SREBP-1c and represses ATP-binding …

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Isolated low-HDL cholesterol in Japanese patients with type 2 diabetes

Koki Matsumura, Yuki Kimura, Hiroshi Murakami, Maki Yamashita et autres

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HYPERINSULINEMIA LEADS THE ELEVATION OF PLASMA ALDOSTERONE CONCENTRATION INDEPENDENTLY WITH OBESITY, DYSLIPIDEMIA, AND INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Yuki Kimura, Jun Matsui, Koki Matsumura, Hiroshi Murakami et autres

The study was to define plasma insulin level with the association of renin-angiotensin-aldosterone system activity in patients with type 2 diabetes. One hundred fi fty type 2 diabetic patients and 24 non-diabetic subjects were studied. There was no statistical diff erence between …

2型糖尿病患者において高インスリン血症は肥満,脂質異常症,インスリン抵抗性とは独立して血漿アルドステロン濃度上昇に関与している

裕輝 木村, 淳 松井, 功貴 松村, Hiroshi Murakami et autres

Reduction of paraoxonase-1 activity may contribute the qualitative impairment of HDL particles in patients with type 2 diabetes

Hiroshi Murakami, Jutaro Tanabe, Naoki Tamasawa, Koki Matsumura et autres

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Regulation and Roles of Urocortins in the Vascular System

Kazunori Kageyama, Ken Teui, Naoki Tamasawa, Toshihiro Suda

Urocortins (Ucns) are members of the corticotropin-releasing factor (CRF) family of peptides. Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF(2) receptor). Regulation and roles of each Ucn have been determined in the vascular system. …

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Differential regulation of gonadotropin-releasing hormone by corticotropin-releasing factor family peptides in hypothalamic N39 cells

Kazunori Kageyama, Gen Hasegawa, Kanako Akimoto, Satoshi Yamagata et autres

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Dexamethasone stimulates the expression of ghrelin and its receptor in rat hypothalamic 4B cells

Kazunori Kageyama, Kanako Akimoto, Satoshi Yamagata, Aya Sugiyama et autres

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