Accès ouvert
2025
article
OpenAlex
Beryl C Zhuang, Marcia Smiti Jude, Chaini Konwar, Natan Yusupov et autres
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains most of the probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPIC versions in DNA methylation-based tools has not yet been investigated. …
ca, de, us, vn, ph
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Accès ouvert
2024
preprint
OpenAlex
Beryl C. Zhuang, Marcia Smiti Jude, Chaini Konwar, Natan Yusupov et autres
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains a majority of probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPIC versions in DNA methylation-based tools has not yet been investigated. …
ca, de, us, vn, ph
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alana Rosenberg, Lisa B. Puglisi, Kathryn A. Thomas, Alexandra A. Halberstam et autres
For the millions of people incarcerated in United States' prisons and jails during the COVID-19 pandemic, isolation took many forms, including medical isolation for those sick with COVID-19, quarantine for those potentially exposed, and prolonged facility-wide lockdowns. Incarcerated people's lived experience of …
us
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Accès ouvert
2024
article
OpenAlex
Xinyi Zhang, Yuan Gao, Keyun Tang, Zongyu Li et autres
Zhang et al. demonstrate that the diabetes drug rosiglitazone improves the efficacy of immunotherapy in mouse melanoma. This effect is both direct and indirect: TZD directly reduces PD-1 expression in CD8+ T cells (i.e., reduces exhaustion), and indirectly reduces exhaustion by lowering …
us, cn
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Accès ouvert
2023
article
OpenAlex
Xinyi Zhang, Won D. Lee, Brooks P. Leitner, Wanling Zhu et autres
We identify a new metabolic target for cancer-related fatigue, dichloroacetate (DCA). They demonstrate that in mice, DCA preserves physical function and protects against the detrimental effects of cancer treatment by reducing cancer-induced increases in circulating lactate. As DCA is already FDA approved …
us
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Accès ouvert
2023
preprint
OpenAlex
Zongyu Li, Xinyi Zhang, Wanling Zhu, Cuiling Zhang et autres
Abstract Metabolic homeostasis is one of the most exquisitely tuned systems in mammalian physiology. Metabolic homeostasis requires multiple redundant systems to cooperate to maintain blood glucose concentrations in a narrow range, despite a multitude of physiological and pathophysiological pressures. Cancer is one …
us
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2023
conference-abstract
OpenAlex
Xinyi Zhang, Won D. Lee, Brooks P. Leitner, Wanling Zhu et autres
Abstract In this study, we identified a potential practice-changing approach, dichloroacetate (DCA), to harness metabolic adjuvant therapy to treat cancer-related fatigue (CRF). CRF is one of the most common complications in patients with multiple cancer types. Although CRF severely affects patients’ quality …
us
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Accès ouvert
2022
article
OpenAlex
Xinyi Zhang, Alexandra A. Halberstam, Wanling Zhu, Brooks P. Leitner et autres
BACKGROUND: Research about tumor "metabolic flexibility"-the ability of cells to toggle between preferred nutrients depending on the metabolic context-has largely focused on obesity-associated cancers. However, increasing evidence for a key role for nutrient competition in the tumor microenvironment, as well as for …
us
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Accès ouvert
2022
article
OpenAlex
Ngozi D. Akingbesote, Aaron D. Norman, Wanling Zhu, Alexandra A. Halberstam et autres
Increasing evidence highlights approaches targeting metabolism as potential adjuvants to cancer therapy. Sodium-glucose transport protein 2 (SGLT2) inhibitors are the newest class of antihyperglycemic drugs. To our knowledge, SGLT2 inhibitors have not been applied in the neoadjuvant setting as a precision medicine …
us
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Accès ouvert
2021
article
OpenAlex
Laura Hawks, Evangeline Lopoo, Lisa B. Puglisi, Jacqueline Cellini et autres
There is growing support to reverse mass incarceration in the United States, especially in the wake of the COVID-19 pandemic. Little is known about what types and scale of community investments are most effective to support mass decarceration. Using a public health …
us
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Accès ouvert
2021
preprint
OpenAlex
Ngozi D. Akingbesote, Aaron D. Norman, Wanling Zhu, Alexandra A. Halberstam et autres
Abstract Increasing evidence highlights the possibility for approaches targeting metabolism as potential adjuvants to cancer therapy. Sodium-glucose transport protein 2 (SGLT2) inhibitors are the newest class of antihyperglycemic therapies, and have recently been highlighted as a novel therapeutic approach to breast cancer. …
us
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Accès ouvert
2021
article
OpenAlex
Lisa B. Puglisi, Alexandra A. Halberstam, Jenerius A. Aminawung, Colleen Gallagher et autres
INTRODUCTION: Incarceration is associated with decreased cancer screening rates and a higher risk for hospitalisation and death from cancer after release from prison. However, there is a paucity of data on the relationship between incarceration and cancer outcomes and quality of care. …
us
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