Wanling Zhu

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition

Brooks P. Leitner, Andin Fosam, Won Dong Lee, Kaylee Zilinger et autres

Higher exercise capacity and regular exercise training improve cancer prognosis at all stages of disease. However, the metabolic adaptations to aerobic exercise training that mediate tumor–host interactions are poorly understood. Here, we demonstrate that voluntary wheel running slows tumor growth and repartitions …

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Association of the triglyceride-glucose index with immunotherapy efficacy and long-term prognosis in advanced Non-small cell lung cancer

Lijie Ma, Wanling Zhu, Y.M. Wang, Li Zhao et autres

Background: Non-small cell lung cancer (NSCLC), the most common subtype of primary lung cancer, represents a major component of the global cancer burden. Despite the availability of several immunotherapeutic and immune-combination treatment modalities, its prognosis remains poor. Therefore, it is particularly important …

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Breaking the psoriasis pathological signaling cycle: A novel nanomedicine strategy targeting metabolism and oxidative stress

Fu‐Gen Wu, Xing Xia, Yuqi Han, Zihao Huang et autres

Psoriasis is a chronic skin disorder characterized by dysregulation of immune and epithelial cells, resulting in persistent symptoms such as erythema, scaling, and induration. The abnormal metabolism and increased oxidative stress in psoriasis lesions have been identified as key drivers in the …

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Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice

John Gonzalez, Olivia H Scharfman, Wanling Zhu, Jessica Kasamoto et autres

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Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy

Longfa Kou, Yitianhe Xu, Shize Li, Zhinan He et autres

INTRODUCTION: Acute lung injury (ALI) is a life-threatening condition characterized by rapidly progressing respiratory distress and hypoxemia. Oxidative stress-induced inflammation in lung tissue plays a crucial role in the progression of ALI. Excessive generation of reactive oxygen species (ROS) in the pulmonary …

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Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1/M2 balance for osteoarthritis therapy

Ruijie Chen, Shimin Zheng, Xinyu Zhao, Huirong Huang et autres

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Iron ion driven remote loading of galloylated cabazitaxel prodrugs for synergistic ferroptosis and chemotherapy

Baoyue Zhang, Jiang Yu, Ruiping Huang, Jianying Ye et autres

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Enhancing chemoimmunotherapy for colorectal cancer with paclitaxel and alantolactone via CD44-Targeted nanoparticles: A STAT3 signaling pathway modulation approach

Fu‐Gen Wu, Xingsi An, Shize Li, Chenyu Qiu et autres

Chemoimmunotherapy has the potential to enhance chemotherapy and modulate the immunosuppressive tumor microenvironment by activating immunogenic cell death (ICD), making it a promising strategy for clinical application. Alantolactone (A) was found to augment the anticancer efficacy of paclitaxel (P) at a molar …

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Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system

Guangyong Lin, Huirong Huang, Meng Sun, Zhinan He et autres

Osteoarthritis (OA) remains a challenging degenerative joint disease, largely associated with chondrocyte apoptosis during its development. Preserving chondrocytes stands as a promising strategy for OA treatment. Rapamycin (RP) exhibits chondrocyte protection by fostering autophagy. Nevertheless, the swift clearance of intra-articular injections and …

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P. Gingivalis induce macrophage polarization by regulating hepcidin expression in chronic apical periodontitis

Jinge Dou, Xuan Chen, Jinglan Zhang, Lei Yang et autres

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Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses

Xinyu Zhao, Huirong Huang, Xinyu Jiang, Shimin Zheng et autres

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Ferroptosis and tumor immunity: In perspective of the major cell components in the tumor microenvironment

Wanling Zhu, Xiaowei Liu, Lei Yang, Qiang He et autres

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