Yuanyuan Liu

STX1B variant-specific synaptic dysfunction is associated with network hyperexcitability in human iPSC-derived neurons

Carolin Haag, Felix Gsell, Oleg Vinogradov, Morgana Barroso Oquendo et autres

BACKGROUND: Variants in STX1B/syntaxin-1B are linked to a spectrum of fever-associated epilepsy syndromes. While studies in murine models have provided mechanistic insights, their relevance to human disease in a heterozygous context may be limited. METHODS: We investigated two pathogenic STX1B variants using …

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The prevalence, recognition, and treatment of depression and anxiety symptoms among Chinese cardiovascular outpatients

Rong Chen, Yuanyuan Liu, Shicheng Yang, Guolong Yu et autres

Cardiovascular diseases (CVDs) have been the leading cause of death in China. Depression and anxiety are recognized as significant risk factors for poor prognosis and disability among Chinese CVD patients. However, these mental health conditions have received limited clinical attention in the …

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Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathy

Yana Reva, Katharina Ulrich, Xian Xin, Yuanyuan Liu et autres

Abstract Developmental and epileptic encephalopathies caused by pathogenic variants in SCN2A ( SCN2A -DEE), encoding the voltage-gated sodium channel Na v 1.2, present with early-life seizures, developmental delay, and increased mortality. Using a novel Scn2a p.A263V gain-of-function (GOF) mouse model, we demonstrate …

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When will companies talk more about innovation? A natural experiment of intellectual property protection

Rui Huang, Yuanyuan Liu, Zhe Zhang

ABSTRACT: We argue that strong protection of intellectual property rights lowers proprietary costs faced by companies, thereby safeguarding their disclosure of innovation information. This paper employs a natural experiment in China to investigate whether and how enhanced intellectual property judicial protection affects …

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The Status of Medication Literacy in Young Patients With Hypertension and Its Relationship With Medication Adherence

Xing Ming, Anping Lu, Yuanyuan Liu, Jun Yang et autres

BACKGROUND: Previous investigators have shown that low levels of ML were associated with poor medication adherence, but few have explored this relationship in young patients with hypertension. OBJECTIVE: In this study, our objective was to analyze the current state of ML in …

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Enhancing real-time object detection for UAVs using optimized YOLOv8 architecture

Wenrui Li, Na Liu, Pizhen Zhang, Yuanyuan Liu

Unmanned Aerial Vehicles (UAVs) have become an essential tool for various applications such as surveillance, environmental monitoring, and disaster management. Real-time object detection from UAVs, however, is hindered by challenges such as varying object scales, changing perspectives, limited computational resources, and unpredictable …

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Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disorder in adolescents

Jing Wang, Yueqi Zhang, Yuanyuan Liu, Jingli Zhang et autres

Background: Major depressive disorder (MDD) frequently results in suboptimal treatment outcomes and elevated recurrence rate, with patients frequently engaging in self-harm and suicidal behavior, thereby placing a heavy burden on families and society. Specifically, MDD in adolescents is linked to an elevated …

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Single frame memory-effect based bispectral analysis for high-resolution imaging through scattering media

Pan Zhang, Yuanyuan Liu, Qiwen Zhan

Imaging through scattering media remains a formidable challenge in optical imaging.Exploiting the memory effect presents new opportunities for non-invasive imaging through the scattering medium by leveraging speckle correlations.Traditional speckle correlation imaging often utilizes a random phase as the initial phase, leading to …

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The impact of electrical stimulation on NaCl diffusion in tenderloin and the quality of dry-cured loin during the marination process

Yuanyuan Liu, Chun Jimmie Ye, Linggao Liu, Li Chen et autres

The effects of electrical stimulation (ES) during the post-processing stage on NaCl diffusion, microstructure, and overall quality in the dry curing of pork tenderloin were investigated. ES treatment significantly increased the salt content in pork tenderloin, with the A2ES group (ES applied …

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EV166/#936 Fertility-sparing treatment outcomes for endometrial cancer and atypical hyperplasia patients with molecular subtypes beyond NSMP

Yiqin Wang, Jianliu Wang, Linlin Bo, Nan Kang et autres

Mendelian randomization analysis and validation supports MEGF9 and MLLT11 as potential targets for the treatment of varicocele and male infertility

Bin Cai, Dalin Sun, Weimin Deng, Yihan Jin et autres

Objective A growing body of research suggests a link between varicocele and male infertility (MI). However, current evidence is mainly based on retrospective studies, which are prone to interference from confounding factors and cannot establish causal relationships. Mendelian randomization (MR) studies on …

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Characterization of Intestinal Flora in Osteoporosis Patients Based on 16S rDNA Sequencing

Mengyue Sun, Yuanyuan Liu, Shan Tang, Yiming Li et autres

Aim: This study investigated differences in gut flora between osteoporosis (OP) patients and healthy individuals using 16S rDNA sequencing. The correlation between differential flora abundance and bone mineral density (BMD) was analyzed, and key flora and potential mechanisms associated with OP were …

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