Felix Gsell

STX1B variant-specific synaptic dysfunction is associated with network hyperexcitability in human iPSC-derived neurons

Carolin Haag, Felix Gsell, Oleg Vinogradov, Morgana Barroso Oquendo et autres

BACKGROUND: Variants in STX1B/syntaxin-1B are linked to a spectrum of fever-associated epilepsy syndromes. While studies in murine models have provided mechanistic insights, their relevance to human disease in a heterozygous context may be limited. METHODS: We investigated two pathogenic STX1B variants using …

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Syn-TEF1 restores the functional disease phenotype of SCA27B in a hiPSC-derived neuronal model

Felix Gsell, David Pellerin, Oleg Vinogradov, Stephan L. Zuchner et autres

Abstract Spinocerebellar Ataxia 27B (SCA27B), caused by a deep-intronic GAA•TTC repeat expansion in the first intron of the FGF14 gene, is one of the most frequent genetic ataxias. Its underlying disease mechanisms remain largely unknown, and disease-modifying therapies targeting upstream processes are …

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LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K v 1 Loss and Increased Action Potential Broadening

Andreas Ritzau‐Jost, Felix Gsell, Josefine Sell, Stefan Sachs et autres

BACKGROUND AND OBJECTIVES: Autoantibodies against the protein leucine-rich glioma inactivated 1 (LGI1) cause the most common subtype of autoimmune encephalitis with predominant involvement of the limbic system, associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part of a …

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Iron Weichard, Holger Taschenberger, Felix Gsell, Grit Bornschein et autres

Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases the initial synaptic strength but also short-term depression during high-frequency transmission. This classical form of presynaptic LTP has been …

de (code pays fourni par la source)

LGI1 autoantibodies enhance synaptic transmission by presynaptic K v 1 loss and increased action potential broadening

Andreas Ritzau‐Jost, Felix Gsell, Josefine Sell, Stefan Sachs et autres

Abstract Background and Objectives Autoantibodies against the neuronally secreted protein leucine-rich glioma inactivated 1 (LGI1) cause the most common subtype of autoimmune limbic encephalitis associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part of a transsynaptic protein complex …

de, at, gb (code pays fourni par la source)

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Iron Weichard, Holger Taschenberger, Felix Gsell, Grit Bornschein et autres

Abstract Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons LTP increases the initial synaptic strength but also short-term depression during high-frequency transmission. This classical form of presynaptic LTP has …

de (code pays fourni par la source)