Neuroimaging Correlates of Altered Sense of Agency in First-Episode Schizophrenia-Spectrum Patients: A Comparative Study Across Two Sites
Rattachement africain : cz, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Disturbances in the sense of agency are a key marker of schizophrenia and are closely linked to core symptoms such as hallucinations and delusions of influence. Neuroimaging studies have implicated cortical midline structures and the defaul t mode network (DMN) associated with self-related processing, but replication across sites and larger samples is needed. Methods We examined neural correlates of self versus other-agency judgments in two independent cohorts of first-episode schizophrenia patients ( n = 177) and controls ( n = 123) recruited at separate MRI centers. During fMRI, participants performed an agency-related task. Data was analyzed using independent component analysis and statistical parametric mapping, focusing on networks associated with self-referential processing. Results Across both sites, self-agency consistently engaged the anterior and posterior cingulate cortex and the precuneus, key regions of the DMN. Schizophrenia patients exhibited significantly reduced DMN activation duri ng self-referential processing compared to controls. While site-related differences were noted in the magnitude of activation, the core pattern of DMN disruption was robust across analytic approaches and datasets. Conclusions This study replicates and extends prior findings of altered self-agency processing in schizophrenia, demonstrating consistent DMN hypo-activation in first-episode patients across two independent cohorts. These results validate the agency paradigm as a reliable probe of self-related neural mechanisms and support models of schizophrenia as a disorder of altered self-perception.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neuroimaging Correlates of Altered Sense of Agency in First-Episode Schizophrenia-Spectrum Patients: A Comparative Study Across Two Sites
- Date Crossref
- 10/10/2025
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Czech Technical University in Prague pays non établi dans la noticeUniversité ou école supérieure
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Institute of Clinical and Experimental Medicine pays non établi dans la noticeÉtablissement de santé
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National Institute of Mental Health pays non établi dans la noticeOrganisme public
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Faculty of Electrical Engineering Institute of Computer Science pays non établi dans la noticeUniversité ou école supérieure
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Institute for Clinical and Experimental Medicine pays non établi dans la noticeStructure de recherche
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National Institute of Menta Health pays non établi dans la noticeStructure de recherche
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Institute of Computer Science Czech Academy of Sciences pays non établi dans la noticeStructure de recherche
Czech Technical University in Prague, Institute of Clinical and Experimental Medicine et National Institute of Mental Health, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.