Aziz M. Mezlini

American Life in Realtime: Benchmark, publicly available person-generated health data for equity in precision health

Ritika Chaturvedi, Marco Angrisani, Wendy Troxel, Monika Jain et autres

Abstract Person-generated health data (PGHD) from smartphones/wearables are invaluable for precision health, a field promoting health equity through tailored disease prevention, detection, and intervention strategies. However, pervasive convenience sampling in extant PGHD research introduces selection biases that systematically underrepresent disadvantaged groups, limit …

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CN39 Exploring the pleasure of eating within children undergoing chemotherapy

M. Khlif, Hajer Ben Mansour, H. Mrad, Yosr Zenzri et autres

CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

Shantanu Jain, Constantina Bakolitsa, Steven E. Brenner, Predrag Radivojac et autres

BACKGROUND: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind …

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Precision recruitment for high-risk participants in a COVID-19 cohort study

Aziz M. Mezlini, Eamon Caddigan, Allison Shapiro, Ernesto Ramirez et autres

Background: Studies for developing diagnostics and treatments for infectious diseases usually require observing the onset of infection during the study period. However, when the infection base rate incidence is low, the cohort size required to measure an effect becomes large, and recruitment …

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Neoadjuvant endocrine therapy with or without palbociclib in low-risk patients: a phase III randomized double-blind SAFIA trial

Khalid Alsaleh, Heba Al Zahwahry, A. Bounedjar, Mohammed Oukkal et autres

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Estimating the Burden of Influenza-like Illness on Daily Activity at the Population Scale Using Commercial Wearable Sensors

Aziz M. Mezlini, Allison Shapiro, Eric J. Daza, Eamon Caddigan et autres

Importance: The severity of viral infections can vary widely, from asymptomatic cases to complications leading to hospitalizations and death. Milder cases, despite being more prevalent, often go undocumented, and their public health burden is not accurately estimated. Objective: To estimate the true …

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Precision recruitment for high-risk participants in a COVID-19 research study

Aziz M. Mezlini, Eamon Caddigan, Allison Shapiro, Ernesto Ramirez et autres

Abstract Studies for developing diagnostics and treatments for infectious diseases usually require observing the onset of infection during the study period. However, when the infection base rate incidence is low, the cohort size required to measure an effect becomes large, and recruitment …

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Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease

Alberto Serrano‐Pozo, Zhaozhi Li, Ayush Noori, Huong Nguyen et autres

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Estimating the Burden of Influenza on Daily Activity at Population Scale Using Commercial Wearable Sensors

Aziz M. Mezlini, Allison Shapiro, Eric J. Daza, Eamon Caddigan et autres

ABSTRACT The severity of viral infections can vary widely, from asymptomatic cases to complications leading to hospitalizations and death. Milder cases, despite being more prevalent, often go undocumented and their public health impact unaccounted for. We estimated the burden of influenza-like-illness (ILI) …

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Finding associations in a heterogeneous setting: statistical test for aberration enrichment

Aziz M. Mezlini, Sudeshna Das, Anna Goldenberg

Most two-group statistical tests find broad patterns such as overall shifts in mean, median, or variance. These tests may not have enough power to detect effects in a small subset of samples, e.g., a drug that works well only on a few …

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Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum

Ayush Noori, Aziz M. Mezlini, Bradley T. Hyman, Alberto Serrano‐Pozo et autres

In Noori et al. [1], we hypothesized that there is a shared gene expression signature underlying neurodegenerative proteinopathies including Alzheimer's disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum. To test this hypothesis, we performed …

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Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Ayush Noori, Aziz M. Mezlini, Bradley T. Hyman, Alberto Serrano‐Pozo et autres

Neurodegenerative disorders such as Alzheimer's disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are defined by the accumulation of specific misfolded protein aggregates. However, the mechanisms by which each proteinopathy leads to neurodegeneration remain …

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