Maha Sinane

Anti-prion drugs reduce endoplasmic reticulum stress and protect human dopaminergic neurons from death

Lucile Gentile, Adeel Nasir, Anaëlle Timoner, Maha Sinane et autres

Parkinson's disease (PD) is characterized by the pathologic aggregation of α-synuclein, which induces endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR), ultimately leading to the death of dopaminergic neurons. This study investigated whether drugs known to mitigate protein aggregation …

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Potential of Marine Sponge Metabolites against Prions: Bromotyrosine Derivatives, a Family of Interest

Maha Sinane, Colin Grunberger, Lucile Gentile, Céline Moriou et autres

The screening of 166 extracts from tropical marine organisms (invertebrates, macroalgae) and 3 cyclolipopeptides from microorganisms against yeast prions highlighted the potential of Verongiida sponges to prevent the propagation of prions. We isolated the known compounds purealidin Q (1), aplysamine-2 (2), pseudoceratinine …

fr, pf (code pays fourni par la source)

Saving dopaminergic neurons from endoplasmic reticulum (ER) stress - A breakthrough approach to fight Parkinson's disease

Luigi Gentile, Amar Nasir, Maha Sinane, P.L. Conan et autres

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Caractérisation du potentiel thérapeutique et du mode d’action de nouveaux composés anti-prions dans le cadre des maladies à prions et d'autres protéinopathies

Maha Sinane

Les maladies à prions sont un groupe de protéinopathies neurodégénératives rares, transmissibles, dont l’agent responsable est la PrPSc, la forme pathologique de la protéine prion. Les mécanismes moléculaires sous-jacents à la propagation de la PrPSc sont encore mal connus et aucun traitement …

Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity

Pierre Conan, Alice Léon, Mathilde Gourdel, Claire Rollet et autres

CBS encodes a pyridoxal 5'-phosphate-dependent enzyme that catalyses the condensation of homocysteine and serine to form cystathionine. Due to its implication in some cancers and in the cognitive pathophysiology of Down syndrome, the identification of pharmacological inhibitors of this enzyme is urgently …

fr (code pays fourni par la source)

Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation

Aline Bamia, Maha Sinane, Rima Naït-Saïdi, Jamila Dhiab et autres

fr, us, gb (code pays fourni par la source)