Joyce P. Meints

Protein kinase CK2α′ as a dual modulator of neuroimmune signaling and synaptic dysfunction in tauopathy

Angel White, Peter Gavrilyuk, Robert Henry Thurston, Amal Fickak et autres

BACKGROUND: Tauopathies are a group of neurodegenerative diseases characterized by tau accumulation, neuroinflammation, and synaptic dysfunction, yet effective treatments remain elusive. Protein kinase CK2 is a holoenzyme composed of two regulatory (CK2β) and two catalytic subunits (CK2α and CK2α') and has been …

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Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Balvindar Singh, Ana Covelo, Héctor Martell‑Martínez, Carmen Perez De Nanclares et autres

Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically and neuropathologically highlyrelated α-synucleinopathies that collectively constitute the second leading cause of neurodegenerative dementias. Geneticand neuropathological studies directly implicate α-synuclein (αS) abnormalities in PDD and DLB pathogenesis. However, itis currently …

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Balvindar Singh, Ana Covelo, Héctor Martell‑Martínez, Carmen Perez De Nanclares et autres

Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically and neuropathologically highlyrelated α-synucleinopathies that collectively constitute the second leading cause of neurodegenerative dementias. Geneticand neuropathological studies directly implicate α-synuclein (αS) abnormalities in PDD and DLB pathogenesis. However, itis currently …

Tau pathology in the brainstem monoaminergic neurons reflect resilience to Alzheimer’s disease pathology in the Nun study cases

Maryam Kherad Pezhouh, Gang Chen, Joyce P. Meints, Laura S. Hemmy et autres

The presence of amyloid and tau pathologies is the pathological hallmark of Alzheimer's disease (AD). However, the presence of non-demented individuals with sufficient AD pathology indicates that AD-linked pathology does not always lead to dementia. The current view is that a non-demented …

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UNC-45A drives ATP-independent microtubule severing via defect recognition and repair inhibition, contributing to neurite dystrophy

Asumi Hoshino, Brian T. Castle, Mihir Shetty, Joyce P. Meints et autres

Abstract UNC-45A is the only known ATP-independent microtubule severing protein. Using in vitro reconstitution and TIRF microscopy, we show that, unlike canonical severing enzymes such as katanin, spastin, and fidgetin, which hydrolyze ATP to remove tubulin dimers and promote lattice repair, UNC-45A …

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Tau pathology in the brainstem monoaminergic neurons reflect resilience to Alzheimer’s disease pathology in the Nun Study cases

Maryam Kherad Pezhouh, Gang Chen, Joyce P. Meints, Laura S. Hemmy et autres

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Soluble and Insoluble Lysates from the Human A53T Mutant α-Synuclein Transgenic Mouse Model Induces α-Synucleinopathy Independent of Injection Site

Justin A. Barnes, Scott Vermilyea, Joyce P. Meints, Hector A. Martell-Martinez et autres

Pathological aggregation of α-synuclein (αS) is implicated in the pathogenesis of Parkinson’s disease (PD) and other α-synucleinopathies. The current view is that neuron-to-neuron spreading of αS pathology contributes to the progression of α-synucleinopathy. We used an A53T mutant human αS transgenic mouse …

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Protein kinase CK2α’ as a dual modulator of immune signaling and synaptic dysfunction in Tauopathy

Angel White, Peter Gavrilyuk, Amal Fickak, Nicholas B Rozema et autres

Tauopathies are a group of neurodegenerative diseases characterized by tau accumulation, neuroinflammation, and synaptic dysfunction, yet effective treatments remain elusive. Protein Kinase CK2 has been previously associated with different aspects of tau pathology but genetic evidence for the contribution of CK2 to …

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Intranasal Delivery of Metabolically Resilient Glutathione: In Vivo Pharmacokinetic, Permeation, and Efficacy Studies

Kiran D. Bhilare, Prakashkumar Dobariya, Wei Xie, Jiashu Xie et autres

Nose-to-brain delivery is an attractive drug delivery strategy for the treatment of Alzheimer’s disease (AD) as it offers direct penetration of drugs into the brain by surpassing the blood–brain barrier, while reducing the potential systemic side effects. We developed a glutathione analogue, …

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Soluble and insoluble lysates from the human A53T mutant α-synuclein transgenic mouse model induces α-synucleinopathy independent of injection site

Michael K. Lee, Justin A. Barnes, Scott Vermilyea, Joyce P. Meints et autres

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Data from UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells

Ashley Mooneyham, Yoshie Iizuka, Qing Yang, Courtney E. Coombes et autres

Abstract UNC-45A, a highly conserved member of the UCS (UNC45A/CRO1/SHE4P) protein family of cochaperones, plays an important role in regulating cytoskeletal-associated functions in invertebrates and mammalian cells, including cytokinesis, exocytosis, cell motility, and neuronal development. Here, for the first time, UNC-45A is …

Figure S7 from UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells

Ashley Mooneyham, Yoshie Iizuka, Qing Yang, Courtney E. Coombes et autres

Loss of UNC-45A results in decrease in proliferation rate