Prakashkumar Dobariya

Rational Design of an Electronically Gated Dicyano-BODIPY Platform for Reversible-Covalent Imaging of Methylglyoxal

John M. Talbott, Samrat Kundu, Bo Li, Leslie Hassanein et autres

Reactive α-dicarbonyls, such as methylglyoxal (MGO), are critical biomarkers of carbonyl stress, yet their real-time monitoring is stifled by a selectivity-biocompatibility paradox. Existing probes either suffer from aldehyde promiscuity, failing to distinguish dicarbonyls from the global lipid peroxidation background, or rely on …

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Role of angiotensin-converting enzyme in cognitive aging: evidence from preclinical and clinical studies

Joshua R. Smith, Prakashkumar Dobariya, Tanvi R. Kadam, Swati S. More

Angiotensin-Converting Enzyme (ACE, EC 3.4.15.1), also termed as kininase II or dipeptidyl carboxypeptidase I, is a crucial component of the Renin angiotensin system (RAS). ACE is extensively recognized for its role in the regulation of the cardiovascular system. Emerging evidence supports a …

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Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue

Filip Hanak, Krzysztof Felczak, Prakashkumar Dobariya, Ursula C.H. Girdwood et autres

Natural opioid signals in the brain produced by Met-enkephalin-Arg-Phe are enhanced after blocking its degradation by the N-terminal catalytic domain of angiotensin-converting enzyme.

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Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling

Prakashkumar Dobariya, Jessica M. Williams, Filip Hanak, Patrick E. Rothwell et autres

Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met-enkephalin-Arg-Phe (MERF). Enkephalins are short-lived, endogenous opioid peptides that …

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The Yin-Yang of sulfur dioxide: Effect on cognitive function

Prakashkumar Dobariya, Joshua K. Smith, Swati S. More

Gaseous neurotransmitters drive numerous physiological processes, rendering important their study in pathophysiology. One such gasotransmitter, sulfur dioxide (SO 2 ), is abundantly produced by the cardiovascular system. SO 2 influences hemodynamics and vascular structure, protects from myocardial ischemia and reperfusion, myocardial injury, …

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Intranasal Delivery of Metabolically Resilient Glutathione: In Vivo Pharmacokinetic, Permeation, and Efficacy Studies

Kiran D. Bhilare, Prakashkumar Dobariya, Wei Xie, Jiashu Xie et autres

Nose-to-brain delivery is an attractive drug delivery strategy for the treatment of Alzheimer’s disease (AD) as it offers direct penetration of drugs into the brain by surpassing the blood–brain barrier, while reducing the potential systemic side effects. We developed a glutathione analogue, …

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Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling

Prakashkumar Dobariya, Jessica M. Williams, Filip Hanak, Patrick E. Rothwell et autres

Abstract Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met-enkephalin-Arg-Phe (MERF). Enkephalins are short-lived, endogenous opioid peptides …

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Human Paraoxonase 1: From Bloodstream Enzyme to Disease Fighter & Therapeutic Intervention

Prakash Y. Khandave, Kriti Goyal, Prakashkumar Dobariya, Abhay H. Pande

Human paraoxonase 1 (hPON1) is a Ca2+-dependent metalloenzyme with multifunctional properties. Due to its diverse activities (arylesterase, phosphotriesterase, and lactonase), it plays a significant role in disease conditions. Researchers across the globe have demonstrated different properties of PON1, like anti-oxidant, anti-inflammatory, anti-atherogenic, …

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Current understanding of the link between angiotensin-converting enzyme and pain perception

Kiran D. Bhilare, Prakashkumar Dobariya, Filip Hanak, Patrick E. Rothwell et autres

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Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase

Rohit Singh, Rongrong Jiang, Jessica M. Williams, Prakashkumar Dobariya et autres

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Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice

Prakashkumar Dobariya, Wei Xie, Swetha Pavani Rao, Jiashu Xie et autres

Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is essential for a satisfactory therapeutic outcome. For more versatile therapies that …

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Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

Rohit Singh, Rongrong Jiang, Jessica M. Williams, Prakashkumar Dobariya et autres

ABSTRACT The endogenous opioid system regulates pain through local release of neuropeptides and modulation of their action on opioid receptors. However, the effect of opioid peptides, the enkephalins, is short-lived due to their rapid hydrolysis by enkephalin-degrading enzymes. In turn, an innovative …

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